Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/s42358-022-00238-3 http://hdl.handle.net/11449/231636 |
Resumo: | Background: Rheumatoid Arthritis (RA) is a chronic disabling systemic disease characterized by joint inflammation, and extra-articular manifestations, including peripheral neuropathy, a condition that can be associated with changes in muscle strength, proprioception and postural balance contributing for the risk of falls. The objective of this study is to analyze the incidence of peripheral neuropathy in patients with RA and its association with the occurrence of falls. Methods: Patients were assessed by an electroneuromyography (ENMG) exam and by a questionnaire on accidental falls occurrence in the previous 12 months. They were also assessed on balance by the Short Physical Performance Battery (SPPB), functionality by the Health Assessment Questionnaire (HAQ), disease activity by the Disease Activity Score (DAS-28), neuropathic pain by the Questionnaire for the Diagnosis of Neuropathic Pain (DN4), and cutaneous sensitivity of the feet by the monofilament testing of Semmes–Weinstein. Monthly calls on falls were made in the subsequent six months. Data analysis was performed using the Shapiro–Wilk test for normality and Spearman, Chi-square, and T-student correlation tests, with a significant P level ≤ 0.05. Results: A sample of 33 patients were evaluated. The incidence of peripheral neuropathy was 48.5%, of which 68.7% were axonal and 31.3% myelinic. The sensorimotor type was present in 64.7%, motor in 17.6%, and sensorial in 11.7% of the cases. Neuropathy was associated to balance (P = 0.026), neuropathic pain (P = 0.016), deep tendon reflexes absence (P = 0,049), altered skin sensitivity of the feet (P = 0.029) and fear of falling (P = 0.001). No association was found between peripheral neuropathy and age, gender, disease activity, or functionality. No significant association was found between peripheral neuropathy and occurrence of falls, in a 12-month retrospective and 6-month prospective evaluation. Conclusion: Peripheral neuropathy has a high incidence in patients with RA, and is related to neuropathic pain, altered postural balance, but not to the occurrence of falls. |
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Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall riskAccidental fallsPeripheral nervous system diseasesPostural balanceRheumatoid arthritisBackground: Rheumatoid Arthritis (RA) is a chronic disabling systemic disease characterized by joint inflammation, and extra-articular manifestations, including peripheral neuropathy, a condition that can be associated with changes in muscle strength, proprioception and postural balance contributing for the risk of falls. The objective of this study is to analyze the incidence of peripheral neuropathy in patients with RA and its association with the occurrence of falls. Methods: Patients were assessed by an electroneuromyography (ENMG) exam and by a questionnaire on accidental falls occurrence in the previous 12 months. They were also assessed on balance by the Short Physical Performance Battery (SPPB), functionality by the Health Assessment Questionnaire (HAQ), disease activity by the Disease Activity Score (DAS-28), neuropathic pain by the Questionnaire for the Diagnosis of Neuropathic Pain (DN4), and cutaneous sensitivity of the feet by the monofilament testing of Semmes–Weinstein. Monthly calls on falls were made in the subsequent six months. Data analysis was performed using the Shapiro–Wilk test for normality and Spearman, Chi-square, and T-student correlation tests, with a significant P level ≤ 0.05. Results: A sample of 33 patients were evaluated. The incidence of peripheral neuropathy was 48.5%, of which 68.7% were axonal and 31.3% myelinic. The sensorimotor type was present in 64.7%, motor in 17.6%, and sensorial in 11.7% of the cases. Neuropathy was associated to balance (P = 0.026), neuropathic pain (P = 0.016), deep tendon reflexes absence (P = 0,049), altered skin sensitivity of the feet (P = 0.029) and fear of falling (P = 0.001). No association was found between peripheral neuropathy and age, gender, disease activity, or functionality. No significant association was found between peripheral neuropathy and occurrence of falls, in a 12-month retrospective and 6-month prospective evaluation. Conclusion: Peripheral neuropathy has a high incidence in patients with RA, and is related to neuropathic pain, altered postural balance, but not to the occurrence of falls.Neurology Department Marilia Medical School (FAMEMA), 800 Monte Carmelo Avenue, SPPhysiotheraphy Departament São Paulo State University (UNESP), 737 Hygino Muzzi Filho Avenue, SPRheumathology Department Marilia Medical School (FAMEMA), 800 Monte Carmelo Avenue, SPPhysiotheraphy Departament São Paulo State University (UNESP), 737 Hygino Muzzi Filho Avenue, SPMarilia Medical School (FAMEMA)Universidade Estadual Paulista (UNESP)de Araújo Pereira, Fabiode Almeida Lourenço, Mariana [UNESP]de Assis, Marcos Renato2022-04-29T08:46:42Z2022-04-29T08:46:42Z2022-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s42358-022-00238-3Advances in Rheumatology, v. 62, n. 1, 2022.2523-3106http://hdl.handle.net/11449/23163610.1186/s42358-022-00238-32-s2.0-85126755006Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAdvances in Rheumatologyinfo:eu-repo/semantics/openAccess2024-08-16T15:45:30Zoai:repositorio.unesp.br:11449/231636Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T15:45:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk |
title |
Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk |
spellingShingle |
Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk de Araújo Pereira, Fabio Accidental falls Peripheral nervous system diseases Postural balance Rheumatoid arthritis |
title_short |
Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk |
title_full |
Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk |
title_fullStr |
Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk |
title_full_unstemmed |
Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk |
title_sort |
Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk |
author |
de Araújo Pereira, Fabio |
author_facet |
de Araújo Pereira, Fabio de Almeida Lourenço, Mariana [UNESP] de Assis, Marcos Renato |
author_role |
author |
author2 |
de Almeida Lourenço, Mariana [UNESP] de Assis, Marcos Renato |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Marilia Medical School (FAMEMA) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
de Araújo Pereira, Fabio de Almeida Lourenço, Mariana [UNESP] de Assis, Marcos Renato |
dc.subject.por.fl_str_mv |
Accidental falls Peripheral nervous system diseases Postural balance Rheumatoid arthritis |
topic |
Accidental falls Peripheral nervous system diseases Postural balance Rheumatoid arthritis |
description |
Background: Rheumatoid Arthritis (RA) is a chronic disabling systemic disease characterized by joint inflammation, and extra-articular manifestations, including peripheral neuropathy, a condition that can be associated with changes in muscle strength, proprioception and postural balance contributing for the risk of falls. The objective of this study is to analyze the incidence of peripheral neuropathy in patients with RA and its association with the occurrence of falls. Methods: Patients were assessed by an electroneuromyography (ENMG) exam and by a questionnaire on accidental falls occurrence in the previous 12 months. They were also assessed on balance by the Short Physical Performance Battery (SPPB), functionality by the Health Assessment Questionnaire (HAQ), disease activity by the Disease Activity Score (DAS-28), neuropathic pain by the Questionnaire for the Diagnosis of Neuropathic Pain (DN4), and cutaneous sensitivity of the feet by the monofilament testing of Semmes–Weinstein. Monthly calls on falls were made in the subsequent six months. Data analysis was performed using the Shapiro–Wilk test for normality and Spearman, Chi-square, and T-student correlation tests, with a significant P level ≤ 0.05. Results: A sample of 33 patients were evaluated. The incidence of peripheral neuropathy was 48.5%, of which 68.7% were axonal and 31.3% myelinic. The sensorimotor type was present in 64.7%, motor in 17.6%, and sensorial in 11.7% of the cases. Neuropathy was associated to balance (P = 0.026), neuropathic pain (P = 0.016), deep tendon reflexes absence (P = 0,049), altered skin sensitivity of the feet (P = 0.029) and fear of falling (P = 0.001). No association was found between peripheral neuropathy and age, gender, disease activity, or functionality. No significant association was found between peripheral neuropathy and occurrence of falls, in a 12-month retrospective and 6-month prospective evaluation. Conclusion: Peripheral neuropathy has a high incidence in patients with RA, and is related to neuropathic pain, altered postural balance, but not to the occurrence of falls. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:46:42Z 2022-04-29T08:46:42Z 2022-12-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s42358-022-00238-3 Advances in Rheumatology, v. 62, n. 1, 2022. 2523-3106 http://hdl.handle.net/11449/231636 10.1186/s42358-022-00238-3 2-s2.0-85126755006 |
url |
http://dx.doi.org/10.1186/s42358-022-00238-3 http://hdl.handle.net/11449/231636 |
identifier_str_mv |
Advances in Rheumatology, v. 62, n. 1, 2022. 2523-3106 10.1186/s42358-022-00238-3 2-s2.0-85126755006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Advances in Rheumatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128128872087552 |