Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats

Detalhes bibliográficos
Autor(a) principal: Missassi, Gabriela [UNESP]
Data de Publicação: 2017
Outros Autores: Dos Santos Borges, Cibele [UNESP], De Lima Rosa, Josiane [UNESP], Villelae Silva, Patrícia [UNESP], Da Cunha Martins, Airton, Barbosa, Fernando, De Grava Kempinas, Wilma [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2017/2172981
http://hdl.handle.net/11449/177099
Resumo: Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition.
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spelling Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult RatsOxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition.Department of Morphology Institute of Biosciences São Paulo State University (UNESP)Graduate Program in Cell and Structural Biology University of Campinas (UNICAMP)Department of Clinical Analyses Toxicology and Food Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São PauloDepartment of Morphology Institute of Biosciences São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Universidade de São Paulo (USP)Missassi, Gabriela [UNESP]Dos Santos Borges, Cibele [UNESP]De Lima Rosa, Josiane [UNESP]Villelae Silva, Patrícia [UNESP]Da Cunha Martins, AirtonBarbosa, FernandoDe Grava Kempinas, Wilma [UNESP]2018-12-11T17:23:59Z2018-12-11T17:23:59Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2017/2172981Oxidative Medicine and Cellular Longevity, v. 2017.1942-09941942-0900http://hdl.handle.net/11449/17709910.1155/2017/21729812-s2.0-850425895132-s2.0-85042589513.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOxidative Medicine and Cellular Longevity1,5581,558info:eu-repo/semantics/openAccess2023-10-03T06:02:53Zoai:repositorio.unesp.br:11449/177099Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-03T06:02:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
title Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
spellingShingle Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
Missassi, Gabriela [UNESP]
title_short Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
title_full Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
title_fullStr Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
title_full_unstemmed Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
title_sort Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
author Missassi, Gabriela [UNESP]
author_facet Missassi, Gabriela [UNESP]
Dos Santos Borges, Cibele [UNESP]
De Lima Rosa, Josiane [UNESP]
Villelae Silva, Patrícia [UNESP]
Da Cunha Martins, Airton
Barbosa, Fernando
De Grava Kempinas, Wilma [UNESP]
author_role author
author2 Dos Santos Borges, Cibele [UNESP]
De Lima Rosa, Josiane [UNESP]
Villelae Silva, Patrícia [UNESP]
Da Cunha Martins, Airton
Barbosa, Fernando
De Grava Kempinas, Wilma [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Missassi, Gabriela [UNESP]
Dos Santos Borges, Cibele [UNESP]
De Lima Rosa, Josiane [UNESP]
Villelae Silva, Patrícia [UNESP]
Da Cunha Martins, Airton
Barbosa, Fernando
De Grava Kempinas, Wilma [UNESP]
description Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01
2018-12-11T17:23:59Z
2018-12-11T17:23:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2017/2172981
Oxidative Medicine and Cellular Longevity, v. 2017.
1942-0994
1942-0900
http://hdl.handle.net/11449/177099
10.1155/2017/2172981
2-s2.0-85042589513
2-s2.0-85042589513.pdf
url http://dx.doi.org/10.1155/2017/2172981
http://hdl.handle.net/11449/177099
identifier_str_mv Oxidative Medicine and Cellular Longevity, v. 2017.
1942-0994
1942-0900
10.1155/2017/2172981
2-s2.0-85042589513
2-s2.0-85042589513.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oxidative Medicine and Cellular Longevity
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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