Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2017/2172981 http://hdl.handle.net/11449/177099 |
Resumo: | Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition. |
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Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult RatsOxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition.Department of Morphology Institute of Biosciences São Paulo State University (UNESP)Graduate Program in Cell and Structural Biology University of Campinas (UNICAMP)Department of Clinical Analyses Toxicology and Food Sciences School of Pharmaceutical Sciences of Ribeirão Preto University of São PauloDepartment of Morphology Institute of Biosciences São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Universidade de São Paulo (USP)Missassi, Gabriela [UNESP]Dos Santos Borges, Cibele [UNESP]De Lima Rosa, Josiane [UNESP]Villelae Silva, Patrícia [UNESP]Da Cunha Martins, AirtonBarbosa, FernandoDe Grava Kempinas, Wilma [UNESP]2018-12-11T17:23:59Z2018-12-11T17:23:59Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2017/2172981Oxidative Medicine and Cellular Longevity, v. 2017.1942-09941942-0900http://hdl.handle.net/11449/17709910.1155/2017/21729812-s2.0-850425895132-s2.0-85042589513.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOxidative Medicine and Cellular Longevity1,5581,558info:eu-repo/semantics/openAccess2023-10-03T06:02:53Zoai:repositorio.unesp.br:11449/177099Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-03T06:02:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats |
title |
Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats |
spellingShingle |
Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats Missassi, Gabriela [UNESP] |
title_short |
Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats |
title_full |
Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats |
title_fullStr |
Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats |
title_full_unstemmed |
Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats |
title_sort |
Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats |
author |
Missassi, Gabriela [UNESP] |
author_facet |
Missassi, Gabriela [UNESP] Dos Santos Borges, Cibele [UNESP] De Lima Rosa, Josiane [UNESP] Villelae Silva, Patrícia [UNESP] Da Cunha Martins, Airton Barbosa, Fernando De Grava Kempinas, Wilma [UNESP] |
author_role |
author |
author2 |
Dos Santos Borges, Cibele [UNESP] De Lima Rosa, Josiane [UNESP] Villelae Silva, Patrícia [UNESP] Da Cunha Martins, Airton Barbosa, Fernando De Grava Kempinas, Wilma [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Missassi, Gabriela [UNESP] Dos Santos Borges, Cibele [UNESP] De Lima Rosa, Josiane [UNESP] Villelae Silva, Patrícia [UNESP] Da Cunha Martins, Airton Barbosa, Fernando De Grava Kempinas, Wilma [UNESP] |
description |
Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T17:23:59Z 2018-12-11T17:23:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2017/2172981 Oxidative Medicine and Cellular Longevity, v. 2017. 1942-0994 1942-0900 http://hdl.handle.net/11449/177099 10.1155/2017/2172981 2-s2.0-85042589513 2-s2.0-85042589513.pdf |
url |
http://dx.doi.org/10.1155/2017/2172981 http://hdl.handle.net/11449/177099 |
identifier_str_mv |
Oxidative Medicine and Cellular Longevity, v. 2017. 1942-0994 1942-0900 10.1155/2017/2172981 2-s2.0-85042589513 2-s2.0-85042589513.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oxidative Medicine and Cellular Longevity 1,558 1,558 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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_version_ |
1799964413904551936 |