Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions
Autor(a) principal: | |
---|---|
Data de Publicação: | 1999 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1415-47571999000100006 http://hdl.handle.net/11449/65733 |
Resumo: | Chromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells. In addition to normal cells, we identified abnormal karyotypes with clonal numerical and structural chromosome alterations in at least two independently originated primary cultures from each lesion. Our data suggest that chromosomal aberrations can exist in vivo in non-neoplastic lesions. Other abnormalities may be due to genetic instability manifested only in vitro (culture artifacts) or may already have been present in brain tissue, reflecting previous chromosome damage (as a result of exposure to chemical treatment or enviromental clastogens). |
id |
UNSP_e240d1ad3a08095958d47eb5f07e255c |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/65733 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesionsadultbrain diseasebrain tissuecase reportcell culturecell proliferationchromosome aberrationchromosome analysischromosome damageclinical featurefemaleglia cellhumanhuman cellhuman tissuekaryotypemaleschool childChromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells. In addition to normal cells, we identified abnormal karyotypes with clonal numerical and structural chromosome alterations in at least two independently originated primary cultures from each lesion. Our data suggest that chromosomal aberrations can exist in vivo in non-neoplastic lesions. Other abnormalities may be due to genetic instability manifested only in vitro (culture artifacts) or may already have been present in brain tissue, reflecting previous chromosome damage (as a result of exposure to chemical treatment or enviromental clastogens).Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Departamento de Genética Instituto de Biociências UNESP, 18618-000 Botucatu, SPDepartamento de Patologia Faculdade de Med. de Ribeirao Preto USP, Ribeirão Preto, SPDepartamento de Neurologia Hosp. Univ. Regl. do N. do Parana UEL, Londrina, PRDepartamento de Genética Instituto de Biociências UNESP, 18618-000 Botucatu, SPUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Universidade Estadual de Londrina (UEL)Rainho, Cláudia Aparecida [UNESP]Neto, José BarbieriCorrea de Moraes, LamartineRogatto, Silvia Regina [UNESP]2014-05-27T11:19:42Z2014-05-27T11:19:42Z1999-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article25-28http://dx.doi.org/10.1590/S1415-47571999000100006Genetics and Molecular Biology, v. 22, n. 1, p. 25-28, 1999.1415-4757http://hdl.handle.net/11449/6573310.1590/S1415-47571999000100006S1415-47571999000100006WOS:0000800790000062-s2.0-003291232488148235451595040000-0002-0285-1162Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and Molecular Biology1.4930,638info:eu-repo/semantics/openAccess2021-10-22T20:18:55Zoai:repositorio.unesp.br:11449/65733Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:30:14.980641Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions |
title |
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions |
spellingShingle |
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions Rainho, Cláudia Aparecida [UNESP] adult brain disease brain tissue case report cell culture cell proliferation chromosome aberration chromosome analysis chromosome damage clinical feature female glia cell human human cell human tissue karyotype male school child |
title_short |
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions |
title_full |
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions |
title_fullStr |
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions |
title_full_unstemmed |
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions |
title_sort |
Clonal chromosome abnormalities found in three non-neoplastic proliferative brain lesions |
author |
Rainho, Cláudia Aparecida [UNESP] |
author_facet |
Rainho, Cláudia Aparecida [UNESP] Neto, José Barbieri Correa de Moraes, Lamartine Rogatto, Silvia Regina [UNESP] |
author_role |
author |
author2 |
Neto, José Barbieri Correa de Moraes, Lamartine Rogatto, Silvia Regina [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Universidade Estadual de Londrina (UEL) |
dc.contributor.author.fl_str_mv |
Rainho, Cláudia Aparecida [UNESP] Neto, José Barbieri Correa de Moraes, Lamartine Rogatto, Silvia Regina [UNESP] |
dc.subject.por.fl_str_mv |
adult brain disease brain tissue case report cell culture cell proliferation chromosome aberration chromosome analysis chromosome damage clinical feature female glia cell human human cell human tissue karyotype male school child |
topic |
adult brain disease brain tissue case report cell culture cell proliferation chromosome aberration chromosome analysis chromosome damage clinical feature female glia cell human human cell human tissue karyotype male school child |
description |
Chromosome analysis was made of brain lesions from three patients which, according to classical histopathological criteria, did not contain tumor cells. In addition to normal cells, we identified abnormal karyotypes with clonal numerical and structural chromosome alterations in at least two independently originated primary cultures from each lesion. Our data suggest that chromosomal aberrations can exist in vivo in non-neoplastic lesions. Other abnormalities may be due to genetic instability manifested only in vitro (culture artifacts) or may already have been present in brain tissue, reflecting previous chromosome damage (as a result of exposure to chemical treatment or enviromental clastogens). |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-03-01 2014-05-27T11:19:42Z 2014-05-27T11:19:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1415-47571999000100006 Genetics and Molecular Biology, v. 22, n. 1, p. 25-28, 1999. 1415-4757 http://hdl.handle.net/11449/65733 10.1590/S1415-47571999000100006 S1415-47571999000100006 WOS:000080079000006 2-s2.0-0032912324 8814823545159504 0000-0002-0285-1162 |
url |
http://dx.doi.org/10.1590/S1415-47571999000100006 http://hdl.handle.net/11449/65733 |
identifier_str_mv |
Genetics and Molecular Biology, v. 22, n. 1, p. 25-28, 1999. 1415-4757 10.1590/S1415-47571999000100006 S1415-47571999000100006 WOS:000080079000006 2-s2.0-0032912324 8814823545159504 0000-0002-0285-1162 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetics and Molecular Biology 1.493 0,638 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
25-28 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129432821432320 |