The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity

Detalhes bibliográficos
Autor(a) principal: Santos, Juliana I. Dos [UNESP]
Data de Publicação: 2009
Outros Autores: Fernandes, Carlos A. H. [UNESP], Magro, Angelo J. [UNESP], Fontes, Marcos R. M. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2174/092986609788923310
http://hdl.handle.net/11449/225585
Resumo: Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity. © 2009 Bentham Science Publishers Ltd.
id UNSP_e2f3e1a54cdfa92854e61824955a6b46
oai_identifier_str oai:repositorio.unesp.br:11449/225585
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivityMyotoxicityOligomeric conformationPhospholipase a2 homologuesQuaternary structureSnake venomX-ray crystallographyPhospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity. © 2009 Bentham Science Publishers Ltd.Departamento de Física e Biofisica Instituto de Biociéncias UNESP, Botucatu, SPDepartamento de Física e Biofísica Instituto de Biociências UNESP, Botucatu, SPDepartamento de Física e Biofisica Instituto de Biociéncias UNESP, Botucatu, SPDepartamento de Física e Biofísica Instituto de Biociências UNESP, Botucatu, SPUniversidade Estadual Paulista (UNESP)Santos, Juliana I. Dos [UNESP]Fernandes, Carlos A. H. [UNESP]Magro, Angelo J. [UNESP]Fontes, Marcos R. M. [UNESP]2022-04-28T20:54:50Z2022-04-28T20:54:50Z2009-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article887-893http://dx.doi.org/10.2174/092986609788923310Protein and Peptide Letters, v. 16, n. 8, p. 887-893, 2009.0929-8665http://hdl.handle.net/11449/22558510.2174/0929866097889233102-s2.0-68849085882Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProtein and Peptide Lettersinfo:eu-repo/semantics/openAccess2022-04-28T20:54:51Zoai:repositorio.unesp.br:11449/225585Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:31:54.663733Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity
title The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity
spellingShingle The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity
Santos, Juliana I. Dos [UNESP]
Myotoxicity
Oligomeric conformation
Phospholipase a2 homologues
Quaternary structure
Snake venom
X-ray crystallography
title_short The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity
title_full The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity
title_fullStr The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity
title_full_unstemmed The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity
title_sort The intriguing phospholipases A2 homologues: Relevant structural features on myotoxicity and catalytic inactivity
author Santos, Juliana I. Dos [UNESP]
author_facet Santos, Juliana I. Dos [UNESP]
Fernandes, Carlos A. H. [UNESP]
Magro, Angelo J. [UNESP]
Fontes, Marcos R. M. [UNESP]
author_role author
author2 Fernandes, Carlos A. H. [UNESP]
Magro, Angelo J. [UNESP]
Fontes, Marcos R. M. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Santos, Juliana I. Dos [UNESP]
Fernandes, Carlos A. H. [UNESP]
Magro, Angelo J. [UNESP]
Fontes, Marcos R. M. [UNESP]
dc.subject.por.fl_str_mv Myotoxicity
Oligomeric conformation
Phospholipase a2 homologues
Quaternary structure
Snake venom
X-ray crystallography
topic Myotoxicity
Oligomeric conformation
Phospholipase a2 homologues
Quaternary structure
Snake venom
X-ray crystallography
description Phospholipases A2 homologues are found in the venom of Crotalinae snakes, being their main action related to myonecrosis induction. Although many studies on these toxins had already been performed, their mechanism of action remains unclear. Here, important aspects about these toxins are reviewed, including their correct biological assembly and how essential is the natural substitution D49K for their catalytic inactivity. © 2009 Bentham Science Publishers Ltd.
publishDate 2009
dc.date.none.fl_str_mv 2009-08-01
2022-04-28T20:54:50Z
2022-04-28T20:54:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2174/092986609788923310
Protein and Peptide Letters, v. 16, n. 8, p. 887-893, 2009.
0929-8665
http://hdl.handle.net/11449/225585
10.2174/092986609788923310
2-s2.0-68849085882
url http://dx.doi.org/10.2174/092986609788923310
http://hdl.handle.net/11449/225585
identifier_str_mv Protein and Peptide Letters, v. 16, n. 8, p. 887-893, 2009.
0929-8665
10.2174/092986609788923310
2-s2.0-68849085882
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Protein and Peptide Letters
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 887-893
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128667444838400

Registros relacionados