Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation

Detalhes bibliográficos
Autor(a) principal: Donatti, C.
Data de Publicação: 2013
Outros Autores: Brandão, C. V S, Ranzani, J. J T, Perches, C. S. [UNESP], Padovani, C. R. [UNESP], Pellizzon, C. H. [UNESP], Sereno, M. G.
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Repositório Institucional da UNESP
DOI: 10.1590/S0102-09352013000300029
Texto Completo: http://dx.doi.org/10.1590/S0102-09352013000300029
http://hdl.handle.net/11449/76516
Resumo: The repair process induced corneal ulcer in rabbits using platelet-rich plasma in the form of eyedrop or clot was clinically evaluated and compared. Sixty rabbits were divided into four groups of 15 animals, denominated platelet group (PG), clot group (CLG), control group (CG), and amniotic control group (AG). Experimental groups were then subdivided into three groups (M4, M7, M30), corresponding to the end of the evaluation period. There were no differences between treatments regarding ocular sensitivity, chemosis and ocular secretion. The groups treated with PRP either as eyedrop or a clot showed less opacity than the animals treated only with amniotic membrane at the moment of the final evaluation. The presence of corneal ulcers in the groups treated with PRP showed lower intensity than the other groups. Histomorphometric examination showed that corneal epithelization in the initial phase of the lesion was greater when using PRP. The use of amniotic membrane promoted corneal epithelial and stromal thickness, as well as synergism when associated to PRP.
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spelling Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluationCorneaHistomorphometricPlateletRabbitUlcerThe repair process induced corneal ulcer in rabbits using platelet-rich plasma in the form of eyedrop or clot was clinically evaluated and compared. Sixty rabbits were divided into four groups of 15 animals, denominated platelet group (PG), clot group (CLG), control group (CG), and amniotic control group (AG). Experimental groups were then subdivided into three groups (M4, M7, M30), corresponding to the end of the evaluation period. There were no differences between treatments regarding ocular sensitivity, chemosis and ocular secretion. The groups treated with PRP either as eyedrop or a clot showed less opacity than the animals treated only with amniotic membrane at the moment of the final evaluation. The presence of corneal ulcers in the groups treated with PRP showed lower intensity than the other groups. Histomorphometric examination showed that corneal epithelization in the initial phase of the lesion was greater when using PRP. The use of amniotic membrane promoted corneal epithelial and stromal thickness, as well as synergism when associated to PRP.Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SPInstituto de Biociências Universidade Estadual Paulista, Botucatu, SPMédica veterinária autônomaInstituto de Biociências Universidade Estadual Paulista, Botucatu, SPFaculdade de Medicina Veterinária e ZootecniaUniversidade Estadual Paulista (Unesp)Médica veterinária autônomaDonatti, C.Brandão, C. V SRanzani, J. J TPerches, C. S. [UNESP]Padovani, C. R. [UNESP]Pellizzon, C. H. [UNESP]Sereno, M. G.2014-05-27T11:30:39Z2014-05-27T11:30:39Z2013-09-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article809-818application/pdfhttp://dx.doi.org/10.1590/S0102-09352013000300029Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 65, n. 3, p. 809-818, 2013.0102-09351678-4162http://hdl.handle.net/11449/7651610.1590/S0102-09352013000300029S0102-09352013000300029WOS:0003220267000292-s2.0-848831677522-s2.0-84883167752.pdf872789708052228900193937798010690000-0002-4494-4180Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporengArquivo Brasileiro de Medicina Veterinária e Zootecnia0.2860,248info:eu-repo/semantics/openAccess2024-01-27T06:56:29Zoai:repositorio.unesp.br:11449/76516Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:05:44.028153Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
title Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
spellingShingle Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
Donatti, C.
Cornea
Histomorphometric
Platelet
Rabbit
Ulcer
Donatti, C.
Cornea
Histomorphometric
Platelet
Rabbit
Ulcer
title_short Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
title_full Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
title_fullStr Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
title_full_unstemmed Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
title_sort Use of platelet-rich plasma in the treatment of deep corneal ulcers induced in rabbits.clinical and histomorphometric evaluation
author Donatti, C.
author_facet Donatti, C.
Donatti, C.
Brandão, C. V S
Ranzani, J. J T
Perches, C. S. [UNESP]
Padovani, C. R. [UNESP]
Pellizzon, C. H. [UNESP]
Sereno, M. G.
Brandão, C. V S
Ranzani, J. J T
Perches, C. S. [UNESP]
Padovani, C. R. [UNESP]
Pellizzon, C. H. [UNESP]
Sereno, M. G.
author_role author
author2 Brandão, C. V S
Ranzani, J. J T
Perches, C. S. [UNESP]
Padovani, C. R. [UNESP]
Pellizzon, C. H. [UNESP]
Sereno, M. G.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Faculdade de Medicina Veterinária e Zootecnia
Universidade Estadual Paulista (Unesp)
Médica veterinária autônoma
dc.contributor.author.fl_str_mv Donatti, C.
Brandão, C. V S
Ranzani, J. J T
Perches, C. S. [UNESP]
Padovani, C. R. [UNESP]
Pellizzon, C. H. [UNESP]
Sereno, M. G.
dc.subject.por.fl_str_mv Cornea
Histomorphometric
Platelet
Rabbit
Ulcer
topic Cornea
Histomorphometric
Platelet
Rabbit
Ulcer
description The repair process induced corneal ulcer in rabbits using platelet-rich plasma in the form of eyedrop or clot was clinically evaluated and compared. Sixty rabbits were divided into four groups of 15 animals, denominated platelet group (PG), clot group (CLG), control group (CG), and amniotic control group (AG). Experimental groups were then subdivided into three groups (M4, M7, M30), corresponding to the end of the evaluation period. There were no differences between treatments regarding ocular sensitivity, chemosis and ocular secretion. The groups treated with PRP either as eyedrop or a clot showed less opacity than the animals treated only with amniotic membrane at the moment of the final evaluation. The presence of corneal ulcers in the groups treated with PRP showed lower intensity than the other groups. Histomorphometric examination showed that corneal epithelization in the initial phase of the lesion was greater when using PRP. The use of amniotic membrane promoted corneal epithelial and stromal thickness, as well as synergism when associated to PRP.
publishDate 2013
dc.date.none.fl_str_mv 2013-09-03
2014-05-27T11:30:39Z
2014-05-27T11:30:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-09352013000300029
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 65, n. 3, p. 809-818, 2013.
0102-0935
1678-4162
http://hdl.handle.net/11449/76516
10.1590/S0102-09352013000300029
S0102-09352013000300029
WOS:000322026700029
2-s2.0-84883167752
2-s2.0-84883167752.pdf
8727897080522289
0019393779801069
0000-0002-4494-4180
url http://dx.doi.org/10.1590/S0102-09352013000300029
http://hdl.handle.net/11449/76516
identifier_str_mv Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, v. 65, n. 3, p. 809-818, 2013.
0102-0935
1678-4162
10.1590/S0102-09352013000300029
S0102-09352013000300029
WOS:000322026700029
2-s2.0-84883167752
2-s2.0-84883167752.pdf
8727897080522289
0019393779801069
0000-0002-4494-4180
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv Arquivo Brasileiro de Medicina Veterinária e Zootecnia
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0,248
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 809-818
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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dc.identifier.doi.none.fl_str_mv 10.1590/S0102-09352013000300029

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