Adjuvant Therapy with 1% Alendronate Gel for Experimental Periodontitis Treatment in Rats

• Autor(a) principal: Kajimoto, Natália De Campos
• Data de Publicação: 2021
• Outros Autores: Buischi, Yvonne De Paiva, Loomer, Peter Michael, Bromage, Timothy G., Ervolino, Edilson [UNESP], Fucini, Stephen Enrico, Pola, Natália Marcumini, Pirovani, Beatriz Ommati [UNESP], Morábito, Maria Juliana Sismeiro [UNESP], de Almeida, Juliano Milanezi [UNESP], Furlaneto, Flávia Aparecida Chaves, Nagata, Maria José Hitomi [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.5051/JPIS.2100700035; http://hdl.handle.net/11449/233233
• topic: Alendronate; Dental scaling; Periodontal disease; Periodontitis; Rats

Purpose: The aim of this study was to evaluate the effects of locally delivered 1% alendronate (ALN) gel used as an adjunct to non-invasive periodontal therapy. Methods: Ligature-induced periodontitis was performed in 96 rats. The ligature was tied in the cervical area of the mandibular left first molar. The animals were randomly divided into 4 groups: 1) NT, no treatment; 2) SRP, scaling and root planning; 3) SRP/PLA, SRP followed by filling the periodontal pocket with placebo gel (PLA); and 4) SRP/ALN, SRP followed by filling the periodontal pockets with 1% ALN gel. Histomorphometric (percentage of bone in the furcation region [PBF]) and immunohistochemical (receptor activator of nuclear factor-κB ligand, osteoprotegerin, and tartrate-resistant acid phosphatase) analyses were performed. Data were statistically analyzed, with the threshold of statistical significance set at P≤0.05. Results: The SRP, SRP/PLA, and SRP/ALN groups presented a higher PBF than the NT group (P≤0.01) at 7, 15, and 30 days. The SRP/ALN group presented a higher PBF than the SRP/PLA group in all experimental periods, as well as a higher PBF than the SRP group at 15 and 30 days. No differences were observed in the immunohistochemical analyses (P>0.05 for all). Conclusions: Locally delivered 1% ALN gel used as an adjunct to SRP enhanced bone regeneration in the furcation region in a rat model of experimental periodontitis.