Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-865020160040000002 http://hdl.handle.net/11449/178010 |
Resumo: | PURPOSE: To investigate the efficacy of intralesional 20% aspirin injection for treatment of experimental peritoneal endometriosis. METHODS: Peritoneal endometriosis was experimentally induced in forty adult nulligravid female rabbits. On day 30 post-endometriosis induction, rabbits were randomly divided to assess early (10 days) and late (20 days) effects of intralesional injection of physiological saline solution (control groups) in comparison to intralesional injection of 20% bicarbonate aspirin solution (experimental groups) as follows: control group 1 (10 days, n=10); control group 2 (20 days, n=10); experimental group 3 (10 days, n=10); experimental group 4 (20 days, n=10). Resected tissues, including endometriosis foci, were qualitatively (general morphology and signs of inflammatory cells infiltrate, necrosis and apoptosis) and quantitatively (remaining endometriosis area) assessed by histopathological analysis. RESULTS: Extensive necrosis, hemorrhage, apoptosis, and fibrosis were observed in the experimental groups 3 and 4. Groups 1 and 2 presented typical endometrial tissue cysts, respectively. Groups 3 and 4 showed sparse endometrial tissue foci and no endometrial tissue, respectively. Quantitative analysis revealed that aspirin-treated groups 3 and 4 had significantly (p<0.05) smaller remaining endometriosis area, compared to control groups 1 and 2. CONCLUSION: Intralesional 20% aspirin injection caused total destruction of peritoneal endometriosis foci in rabbits. |
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Repositório Institucional da UNESP |
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Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbitsAspirinEndometriosisRabbitsPURPOSE: To investigate the efficacy of intralesional 20% aspirin injection for treatment of experimental peritoneal endometriosis. METHODS: Peritoneal endometriosis was experimentally induced in forty adult nulligravid female rabbits. On day 30 post-endometriosis induction, rabbits were randomly divided to assess early (10 days) and late (20 days) effects of intralesional injection of physiological saline solution (control groups) in comparison to intralesional injection of 20% bicarbonate aspirin solution (experimental groups) as follows: control group 1 (10 days, n=10); control group 2 (20 days, n=10); experimental group 3 (10 days, n=10); experimental group 4 (20 days, n=10). Resected tissues, including endometriosis foci, were qualitatively (general morphology and signs of inflammatory cells infiltrate, necrosis and apoptosis) and quantitatively (remaining endometriosis area) assessed by histopathological analysis. RESULTS: Extensive necrosis, hemorrhage, apoptosis, and fibrosis were observed in the experimental groups 3 and 4. Groups 1 and 2 presented typical endometrial tissue cysts, respectively. Groups 3 and 4 showed sparse endometrial tissue foci and no endometrial tissue, respectively. Quantitative analysis revealed that aspirin-treated groups 3 and 4 had significantly (p<0.05) smaller remaining endometriosis area, compared to control groups 1 and 2. CONCLUSION: Intralesional 20% aspirin injection caused total destruction of peritoneal endometriosis foci in rabbits.Department of Surgery Botucatu Medical School (FMB) Universidade Estadual de São Paulo (UNESP)Department of Surgery FMB UNESPDivision of Coloproctology Department of Surgery FMB UNESPDepartment of Surgery Botucatu Medical School (FMB) Universidade Estadual de São Paulo (UNESP)Department of Surgery FMB UNESPDivision of Coloproctology Department of Surgery FMB UNESPUniversidade Estadual Paulista (Unesp)Saad-Hossne, Rogério [UNESP]Barretto, Adriana Beatriz [UNESP]Siqueira, Juliana Menezes [UNESP]Denadai, Rafael [UNESP]2018-12-11T17:28:09Z2018-12-11T17:28:09Z2016-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article227-234application/pdfhttp://dx.doi.org/10.1590/S0102-865020160040000002Acta Cirurgica Brasileira, v. 31, n. 4, p. 227-234, 2016.1678-26740102-8650http://hdl.handle.net/11449/17801010.1590/S0102-865020160040000002S0102-865020160004002272-s2.0-84966458733S0102-86502016000400227.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileira0,395info:eu-repo/semantics/openAccess2023-11-19T06:10:38Zoai:repositorio.unesp.br:11449/178010Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-19T06:10:38Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits |
title |
Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits |
spellingShingle |
Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits Saad-Hossne, Rogério [UNESP] Aspirin Endometriosis Rabbits |
title_short |
Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits |
title_full |
Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits |
title_fullStr |
Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits |
title_full_unstemmed |
Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits |
title_sort |
Evaluation of peritoneal endometriosis treatment using intralesional acetylsalicylic acid injection in rabbits |
author |
Saad-Hossne, Rogério [UNESP] |
author_facet |
Saad-Hossne, Rogério [UNESP] Barretto, Adriana Beatriz [UNESP] Siqueira, Juliana Menezes [UNESP] Denadai, Rafael [UNESP] |
author_role |
author |
author2 |
Barretto, Adriana Beatriz [UNESP] Siqueira, Juliana Menezes [UNESP] Denadai, Rafael [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Saad-Hossne, Rogério [UNESP] Barretto, Adriana Beatriz [UNESP] Siqueira, Juliana Menezes [UNESP] Denadai, Rafael [UNESP] |
dc.subject.por.fl_str_mv |
Aspirin Endometriosis Rabbits |
topic |
Aspirin Endometriosis Rabbits |
description |
PURPOSE: To investigate the efficacy of intralesional 20% aspirin injection for treatment of experimental peritoneal endometriosis. METHODS: Peritoneal endometriosis was experimentally induced in forty adult nulligravid female rabbits. On day 30 post-endometriosis induction, rabbits were randomly divided to assess early (10 days) and late (20 days) effects of intralesional injection of physiological saline solution (control groups) in comparison to intralesional injection of 20% bicarbonate aspirin solution (experimental groups) as follows: control group 1 (10 days, n=10); control group 2 (20 days, n=10); experimental group 3 (10 days, n=10); experimental group 4 (20 days, n=10). Resected tissues, including endometriosis foci, were qualitatively (general morphology and signs of inflammatory cells infiltrate, necrosis and apoptosis) and quantitatively (remaining endometriosis area) assessed by histopathological analysis. RESULTS: Extensive necrosis, hemorrhage, apoptosis, and fibrosis were observed in the experimental groups 3 and 4. Groups 1 and 2 presented typical endometrial tissue cysts, respectively. Groups 3 and 4 showed sparse endometrial tissue foci and no endometrial tissue, respectively. Quantitative analysis revealed that aspirin-treated groups 3 and 4 had significantly (p<0.05) smaller remaining endometriosis area, compared to control groups 1 and 2. CONCLUSION: Intralesional 20% aspirin injection caused total destruction of peritoneal endometriosis foci in rabbits. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-04-01 2018-12-11T17:28:09Z 2018-12-11T17:28:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-865020160040000002 Acta Cirurgica Brasileira, v. 31, n. 4, p. 227-234, 2016. 1678-2674 0102-8650 http://hdl.handle.net/11449/178010 10.1590/S0102-865020160040000002 S0102-86502016000400227 2-s2.0-84966458733 S0102-86502016000400227.pdf |
url |
http://dx.doi.org/10.1590/S0102-865020160040000002 http://hdl.handle.net/11449/178010 |
identifier_str_mv |
Acta Cirurgica Brasileira, v. 31, n. 4, p. 227-234, 2016. 1678-2674 0102-8650 10.1590/S0102-865020160040000002 S0102-86502016000400227 2-s2.0-84966458733 S0102-86502016000400227.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira 0,395 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
227-234 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046558250303488 |