Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.toxrep.2014.12006 http://hdl.handle.net/11449/164851 |
Resumo: | This study investigated the effects of pre- and peripubertal exposure (PND 15-45) to triphenyltin hydroxide (TPT: 0, 1.875, 3.75, 7.5 and 15 mg/kg bw/d po) on mouse sexual maturation and fertility. Half of the mice were euthanized on PND 46 and the remaining mice were submitted to fertility tests on PND 65-75. TPT caused a transient decrease of weight gain at 3.75 mg/kg bw/d, and deaths and body weight deficits at higher doses. Delays of testes descent (TD), vaginal opening (VO) and first estrus (FE) occurred at doses >3.75 (TD) and >= 7.5 mg/kg bw/d (VO, FE), respectively. Body weight on the days of TD, VO and FE did not differ among groups. TPT at doses >= 3.75 mg/kg decreased sperm and spermatid counts at the end of treatment (PND 46) but no alteration was noted later on PND 75. Testicular histopathology (PND 46) showed a dose-dependent reduction of seminiferous tubules diameter, a greater degree of vacuolation in Sertoli cells and germ cell degeneration and necrosis in TPT-treated mice. TPT did not affect the outcome of fertility tests. Study-derived NOAEL was 1.875 mg TPT/kg bw/d for males and 3.75 mg TPT/kg bw/d for females. The detrimental effects of TPT on spermatogenesis were reversed after treatment discontinuation. (C) 2014 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license. |
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Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periodsTriphenyltinTPTHOrganotin compoundsPubertyPostnatal exposureFertilityThis study investigated the effects of pre- and peripubertal exposure (PND 15-45) to triphenyltin hydroxide (TPT: 0, 1.875, 3.75, 7.5 and 15 mg/kg bw/d po) on mouse sexual maturation and fertility. Half of the mice were euthanized on PND 46 and the remaining mice were submitted to fertility tests on PND 65-75. TPT caused a transient decrease of weight gain at 3.75 mg/kg bw/d, and deaths and body weight deficits at higher doses. Delays of testes descent (TD), vaginal opening (VO) and first estrus (FE) occurred at doses >3.75 (TD) and >= 7.5 mg/kg bw/d (VO, FE), respectively. Body weight on the days of TD, VO and FE did not differ among groups. TPT at doses >= 3.75 mg/kg decreased sperm and spermatid counts at the end of treatment (PND 46) but no alteration was noted later on PND 75. Testicular histopathology (PND 46) showed a dose-dependent reduction of seminiferous tubules diameter, a greater degree of vacuolation in Sertoli cells and germ cell degeneration and necrosis in TPT-treated mice. TPT did not affect the outcome of fertility tests. Study-derived NOAEL was 1.875 mg TPT/kg bw/d for males and 3.75 mg TPT/kg bw/d for females. The detrimental effects of TPT on spermatogenesis were reversed after treatment discontinuation. (C) 2014 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)FIOCRUZ (PAPES-III)Natl Sch Publ Hlth, Dept Biol Sci, Lab Environm Toxicol, Rio De Janeiro, BrazilNatl Inst Hlth Qual Control, Dept Immunol, Rio De Janeiro, BrazilFiocruz MS, Oswaldo Cruz Fdn, BR-21045900 Rio De Janeiro, RJ, BrazilState Univ Sao Paulo UNESP, Dept Morphol, Sao Paulo, BrazilUniv Fed Estado Rio de Janeiro, UNIRIO, Dept Biochem, Rio De Janeiro, BrazilState Univ Sao Paulo UNESP, Dept Morphol, Sao Paulo, BrazilElsevier B.V.Natl Sch Publ HlthNatl Inst Hlth Qual ControlFiocruz MSUniversidade Estadual Paulista (Unesp)Univ Fed Estado Rio de JaneiroMello, Marcia S. CamposDelgado, Isabella F.Favareto, Ana Paula A. [UNESP]Lopes, Camila M. T.Batista, Marcelo M.Kempinas, Wilma De-Grava [UNESP]Paumgartten, Francisco J. R.2018-11-26T22:40:54Z2018-11-26T22:40:54Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article405-414application/pdfhttp://dx.doi.org/10.1016/j.toxrep.2014.12006Toxicology Reports. Amsterdam: Elsevier Science Bv, v. 2, p. 405-414, 2015.2214-7500http://hdl.handle.net/11449/16485110.1016/j.toxrep.2014.12006WOS:000218510700045WOS000218510700045.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengToxicology Reports0,580info:eu-repo/semantics/openAccess2023-09-30T06:01:41Zoai:repositorio.unesp.br:11449/164851Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:32:19.272862Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods |
title |
Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods |
spellingShingle |
Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods Mello, Marcia S. Campos Triphenyltin TPTH Organotin compounds Puberty Postnatal exposure Fertility |
title_short |
Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods |
title_full |
Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods |
title_fullStr |
Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods |
title_full_unstemmed |
Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods |
title_sort |
Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods |
author |
Mello, Marcia S. Campos |
author_facet |
Mello, Marcia S. Campos Delgado, Isabella F. Favareto, Ana Paula A. [UNESP] Lopes, Camila M. T. Batista, Marcelo M. Kempinas, Wilma De-Grava [UNESP] Paumgartten, Francisco J. R. |
author_role |
author |
author2 |
Delgado, Isabella F. Favareto, Ana Paula A. [UNESP] Lopes, Camila M. T. Batista, Marcelo M. Kempinas, Wilma De-Grava [UNESP] Paumgartten, Francisco J. R. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Natl Sch Publ Hlth Natl Inst Hlth Qual Control Fiocruz MS Universidade Estadual Paulista (Unesp) Univ Fed Estado Rio de Janeiro |
dc.contributor.author.fl_str_mv |
Mello, Marcia S. Campos Delgado, Isabella F. Favareto, Ana Paula A. [UNESP] Lopes, Camila M. T. Batista, Marcelo M. Kempinas, Wilma De-Grava [UNESP] Paumgartten, Francisco J. R. |
dc.subject.por.fl_str_mv |
Triphenyltin TPTH Organotin compounds Puberty Postnatal exposure Fertility |
topic |
Triphenyltin TPTH Organotin compounds Puberty Postnatal exposure Fertility |
description |
This study investigated the effects of pre- and peripubertal exposure (PND 15-45) to triphenyltin hydroxide (TPT: 0, 1.875, 3.75, 7.5 and 15 mg/kg bw/d po) on mouse sexual maturation and fertility. Half of the mice were euthanized on PND 46 and the remaining mice were submitted to fertility tests on PND 65-75. TPT caused a transient decrease of weight gain at 3.75 mg/kg bw/d, and deaths and body weight deficits at higher doses. Delays of testes descent (TD), vaginal opening (VO) and first estrus (FE) occurred at doses >3.75 (TD) and >= 7.5 mg/kg bw/d (VO, FE), respectively. Body weight on the days of TD, VO and FE did not differ among groups. TPT at doses >= 3.75 mg/kg decreased sperm and spermatid counts at the end of treatment (PND 46) but no alteration was noted later on PND 75. Testicular histopathology (PND 46) showed a dose-dependent reduction of seminiferous tubules diameter, a greater degree of vacuolation in Sertoli cells and germ cell degeneration and necrosis in TPT-treated mice. TPT did not affect the outcome of fertility tests. Study-derived NOAEL was 1.875 mg TPT/kg bw/d for males and 3.75 mg TPT/kg bw/d for females. The detrimental effects of TPT on spermatogenesis were reversed after treatment discontinuation. (C) 2014 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01-01 2018-11-26T22:40:54Z 2018-11-26T22:40:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.toxrep.2014.12006 Toxicology Reports. Amsterdam: Elsevier Science Bv, v. 2, p. 405-414, 2015. 2214-7500 http://hdl.handle.net/11449/164851 10.1016/j.toxrep.2014.12006 WOS:000218510700045 WOS000218510700045.pdf |
url |
http://dx.doi.org/10.1016/j.toxrep.2014.12006 http://hdl.handle.net/11449/164851 |
identifier_str_mv |
Toxicology Reports. Amsterdam: Elsevier Science Bv, v. 2, p. 405-414, 2015. 2214-7500 10.1016/j.toxrep.2014.12006 WOS:000218510700045 WOS000218510700045.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Toxicology Reports 0,580 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
405-414 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128244206010368 |