Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1093/nutrit/nuaa101 http://hdl.handle.net/11449/228951 |
Resumo: | CONTEXT: Although nutrition is considered an important intervention for the management of frailty, the actual effectiveness of interventions addressing nutrition in frail older people remains unclear. OBJECTIVE: The aim for this systematic review was to appraise the evidence regarding the effectiveness of nutritional interventions for the management of frailty in older adults. DATA EXTRACTION: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, Web of Science, and Latin American and Caribbean Health Sciences Literature databases were searched from January 2001 to November 2019. Two independent reviewers extracted relevant data. From 2370 initial records, 19 publications presenting data from 17 studies (1564 individuals; follow-up: 7-96 weeks) were included. DATA ANALYSIS: None of the Bayesian random-effects meta-analyses comparing nutritional supplements with placebo regarding mortality, body mass index, weight, frailty status, muscle strength, gait speed, body composition, and cognitive function showed statistically significant differences. The same applies to a single meta-analysis comparing nutritional education with general health advice regarding muscle strength. CONCLUSION: Our results suggest, mostly with low to very low degrees of certainty, that nutritional supplements or nutritional education delivered in isolation may not be effective for the management of frailty in older people. REVIEW REGISTRATION NUMBER: CRD42018111510 (PROSPERO). |
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Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trialsageddietary supplementsfrailtymeta-analysisnutritionsystematic reviewCONTEXT: Although nutrition is considered an important intervention for the management of frailty, the actual effectiveness of interventions addressing nutrition in frail older people remains unclear. OBJECTIVE: The aim for this systematic review was to appraise the evidence regarding the effectiveness of nutritional interventions for the management of frailty in older adults. DATA EXTRACTION: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, Web of Science, and Latin American and Caribbean Health Sciences Literature databases were searched from January 2001 to November 2019. Two independent reviewers extracted relevant data. From 2370 initial records, 19 publications presenting data from 17 studies (1564 individuals; follow-up: 7-96 weeks) were included. DATA ANALYSIS: None of the Bayesian random-effects meta-analyses comparing nutritional supplements with placebo regarding mortality, body mass index, weight, frailty status, muscle strength, gait speed, body composition, and cognitive function showed statistically significant differences. The same applies to a single meta-analysis comparing nutritional education with general health advice regarding muscle strength. CONCLUSION: Our results suggest, mostly with low to very low degrees of certainty, that nutritional supplements or nutritional education delivered in isolation may not be effective for the management of frailty in older people. REVIEW REGISTRATION NUMBER: CRD42018111510 (PROSPERO).Public Health Department São Paulo State University Botucatu Medical SchoolDepartment of Primary Care and Population Health University College LondonAnesthesiology Department Botucatu Medical School São Paulo State UniversityInternal Medicine Department Botucatu Medical School São Paulo State UniversityPublic Health Department São Paulo State University Botucatu Medical SchoolAnesthesiology Department Botucatu Medical School São Paulo State UniversityInternal Medicine Department Botucatu Medical School São Paulo State UniversityUniversidade Estadual Paulista (UNESP)University College LondonMoraes, Mariana B de [UNESP]Avgerinou, ChristinaFukushima, Fernanda B. [UNESP]Vidal, Edison I O [UNESP]2022-04-29T08:29:32Z2022-04-29T08:29:32Z2021-07-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article889-913http://dx.doi.org/10.1093/nutrit/nuaa101Nutrition reviews, v. 79, n. 8, p. 889-913, 2021.1753-4887http://hdl.handle.net/11449/22895110.1093/nutrit/nuaa1012-s2.0-85106992252Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNutrition reviewsinfo:eu-repo/semantics/openAccess2022-04-29T08:29:32Zoai:repositorio.unesp.br:11449/228951Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T11:10:08.889068Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials |
title |
Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials |
spellingShingle |
Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials Moraes, Mariana B de [UNESP] aged dietary supplements frailty meta-analysis nutrition systematic review |
title_short |
Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials |
title_full |
Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials |
title_fullStr |
Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials |
title_full_unstemmed |
Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials |
title_sort |
Nutritional interventions for the management of frailty in older adults: systematic review and meta-analysis of randomized clinical trials |
author |
Moraes, Mariana B de [UNESP] |
author_facet |
Moraes, Mariana B de [UNESP] Avgerinou, Christina Fukushima, Fernanda B. [UNESP] Vidal, Edison I O [UNESP] |
author_role |
author |
author2 |
Avgerinou, Christina Fukushima, Fernanda B. [UNESP] Vidal, Edison I O [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) University College London |
dc.contributor.author.fl_str_mv |
Moraes, Mariana B de [UNESP] Avgerinou, Christina Fukushima, Fernanda B. [UNESP] Vidal, Edison I O [UNESP] |
dc.subject.por.fl_str_mv |
aged dietary supplements frailty meta-analysis nutrition systematic review |
topic |
aged dietary supplements frailty meta-analysis nutrition systematic review |
description |
CONTEXT: Although nutrition is considered an important intervention for the management of frailty, the actual effectiveness of interventions addressing nutrition in frail older people remains unclear. OBJECTIVE: The aim for this systematic review was to appraise the evidence regarding the effectiveness of nutritional interventions for the management of frailty in older adults. DATA EXTRACTION: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, Web of Science, and Latin American and Caribbean Health Sciences Literature databases were searched from January 2001 to November 2019. Two independent reviewers extracted relevant data. From 2370 initial records, 19 publications presenting data from 17 studies (1564 individuals; follow-up: 7-96 weeks) were included. DATA ANALYSIS: None of the Bayesian random-effects meta-analyses comparing nutritional supplements with placebo regarding mortality, body mass index, weight, frailty status, muscle strength, gait speed, body composition, and cognitive function showed statistically significant differences. The same applies to a single meta-analysis comparing nutritional education with general health advice regarding muscle strength. CONCLUSION: Our results suggest, mostly with low to very low degrees of certainty, that nutritional supplements or nutritional education delivered in isolation may not be effective for the management of frailty in older people. REVIEW REGISTRATION NUMBER: CRD42018111510 (PROSPERO). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-07 2022-04-29T08:29:32Z 2022-04-29T08:29:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1093/nutrit/nuaa101 Nutrition reviews, v. 79, n. 8, p. 889-913, 2021. 1753-4887 http://hdl.handle.net/11449/228951 10.1093/nutrit/nuaa101 2-s2.0-85106992252 |
url |
http://dx.doi.org/10.1093/nutrit/nuaa101 http://hdl.handle.net/11449/228951 |
identifier_str_mv |
Nutrition reviews, v. 79, n. 8, p. 889-913, 2021. 1753-4887 10.1093/nutrit/nuaa101 2-s2.0-85106992252 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutrition reviews |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
889-913 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803045784238686208 |