Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflex

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Laísa Taís Cabral [UNESP]
Data de Publicação: 2019
Outros Autores: da Silva, Eliandra Nunes [UNESP], Horta-Júnior, José de Anchieta C. [UNESP], Gargaglioni, Luciane H. [UNESP], Dias, Mirela B. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.resp.2018.11.007
http://hdl.handle.net/11449/188416
Resumo: It has been shown that the lateral hypothalamus/perifornical area (LH/PFA) exerts an important role on arousal-state variations of the central chemoreflex, but the mechanisms that underlie LH/PFA chemoreception are poorly understood. Here we asked whether glutamate inputs on metabotropic receptors in the LH/PFA modulate the hypercapnic ventilatory response. We studied the effects of microinjection of a glutamate metabotropic receptor (mGluR) antagonist ((+)-α-Methyl-4-carboxyphenylglycine; MCPG; 100 mM) and a selective Group II/III mGluR antagonist ((2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid; LY341495; 5 mM) into the LH/PFA of conscious rats on ventilation in room air and in 7% CO 2 , during wakefulness and sleep, in the dark and light periods of the diurnal cycle. Microinjection of MCPG and LY341495 increased the hypercapnic ventilatory response in both the light and the dark period during wakefulness, but not during sleep, (p < 0.001). Our data suggest that glutamate, acting on Group II/III metabotropic receptors in the LH/PFA, exerts an inhibitory modulation of the hypercapnic ventilatory response in awake rats.
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spelling Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflexCentral chemoreceptionGlutamateHypercapniaHypothalamusOrexinIt has been shown that the lateral hypothalamus/perifornical area (LH/PFA) exerts an important role on arousal-state variations of the central chemoreflex, but the mechanisms that underlie LH/PFA chemoreception are poorly understood. Here we asked whether glutamate inputs on metabotropic receptors in the LH/PFA modulate the hypercapnic ventilatory response. We studied the effects of microinjection of a glutamate metabotropic receptor (mGluR) antagonist ((+)-α-Methyl-4-carboxyphenylglycine; MCPG; 100 mM) and a selective Group II/III mGluR antagonist ((2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid; LY341495; 5 mM) into the LH/PFA of conscious rats on ventilation in room air and in 7% CO 2 , during wakefulness and sleep, in the dark and light periods of the diurnal cycle. Microinjection of MCPG and LY341495 increased the hypercapnic ventilatory response in both the light and the dark period during wakefulness, but not during sleep, (p < 0.001). Our data suggest that glutamate, acting on Group II/III metabotropic receptors in the LH/PFA, exerts an inhibitory modulation of the hypercapnic ventilatory response in awake rats.Department of Physiology Institute of Bioscience Sao Paulo State University-UNESPDepartment of Anatomy Institute of Bioscience Sao Paulo State University-UNESPDepartment of Animal Morphology and Physiology Sao Paulo State University-FCAVDepartment of Physiology Institute of Bioscience Sao Paulo State University-UNESPDepartment of Anatomy Institute of Bioscience Sao Paulo State University-UNESPDepartment of Animal Morphology and Physiology Sao Paulo State University-FCAVUniversidade Estadual Paulista (Unesp)Rodrigues, Laísa Taís Cabral [UNESP]da Silva, Eliandra Nunes [UNESP]Horta-Júnior, José de Anchieta C. [UNESP]Gargaglioni, Luciane H. [UNESP]Dias, Mirela B. [UNESP]2019-10-06T16:07:21Z2019-10-06T16:07:21Z2019-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article122-130http://dx.doi.org/10.1016/j.resp.2018.11.007Respiratory Physiology and Neurobiology, v. 260, p. 122-130.1878-15191569-9048http://hdl.handle.net/11449/18841610.1016/j.resp.2018.11.0072-s2.0-85057268675Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRespiratory Physiology and Neurobiologyinfo:eu-repo/semantics/openAccess2024-06-06T18:41:41Zoai:repositorio.unesp.br:11449/188416Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:40:42.768764Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflex
title Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflex
spellingShingle Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflex
Rodrigues, Laísa Taís Cabral [UNESP]
Central chemoreception
Glutamate
Hypercapnia
Hypothalamus
Orexin
title_short Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflex
title_full Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflex
title_fullStr Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflex
title_full_unstemmed Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflex
title_sort Glutamate metabotropic receptors in the lateral hypothalamus/perifornical area reduce the CO 2 chemoreflex
author Rodrigues, Laísa Taís Cabral [UNESP]
author_facet Rodrigues, Laísa Taís Cabral [UNESP]
da Silva, Eliandra Nunes [UNESP]
Horta-Júnior, José de Anchieta C. [UNESP]
Gargaglioni, Luciane H. [UNESP]
Dias, Mirela B. [UNESP]
author_role author
author2 da Silva, Eliandra Nunes [UNESP]
Horta-Júnior, José de Anchieta C. [UNESP]
Gargaglioni, Luciane H. [UNESP]
Dias, Mirela B. [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Rodrigues, Laísa Taís Cabral [UNESP]
da Silva, Eliandra Nunes [UNESP]
Horta-Júnior, José de Anchieta C. [UNESP]
Gargaglioni, Luciane H. [UNESP]
Dias, Mirela B. [UNESP]
dc.subject.por.fl_str_mv Central chemoreception
Glutamate
Hypercapnia
Hypothalamus
Orexin
topic Central chemoreception
Glutamate
Hypercapnia
Hypothalamus
Orexin
description It has been shown that the lateral hypothalamus/perifornical area (LH/PFA) exerts an important role on arousal-state variations of the central chemoreflex, but the mechanisms that underlie LH/PFA chemoreception are poorly understood. Here we asked whether glutamate inputs on metabotropic receptors in the LH/PFA modulate the hypercapnic ventilatory response. We studied the effects of microinjection of a glutamate metabotropic receptor (mGluR) antagonist ((+)-α-Methyl-4-carboxyphenylglycine; MCPG; 100 mM) and a selective Group II/III mGluR antagonist ((2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid; LY341495; 5 mM) into the LH/PFA of conscious rats on ventilation in room air and in 7% CO 2 , during wakefulness and sleep, in the dark and light periods of the diurnal cycle. Microinjection of MCPG and LY341495 increased the hypercapnic ventilatory response in both the light and the dark period during wakefulness, but not during sleep, (p < 0.001). Our data suggest that glutamate, acting on Group II/III metabotropic receptors in the LH/PFA, exerts an inhibitory modulation of the hypercapnic ventilatory response in awake rats.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:07:21Z
2019-10-06T16:07:21Z
2019-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.resp.2018.11.007
Respiratory Physiology and Neurobiology, v. 260, p. 122-130.
1878-1519
1569-9048
http://hdl.handle.net/11449/188416
10.1016/j.resp.2018.11.007
2-s2.0-85057268675
url http://dx.doi.org/10.1016/j.resp.2018.11.007
http://hdl.handle.net/11449/188416
identifier_str_mv Respiratory Physiology and Neurobiology, v. 260, p. 122-130.
1878-1519
1569-9048
10.1016/j.resp.2018.11.007
2-s2.0-85057268675
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Respiratory Physiology and Neurobiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 122-130
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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