Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10973-018-7019-z http://hdl.handle.net/11449/179559 |
Resumo: | Coordination compounds of transition metals with norfloxacin (Nor) have potential to improve its effectiveness, as already discussed for some compounds found in the literature. The complexes in the solid state were prepared by precipitation of the respective metal cation (M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)) with a norfloxacin sodium salt solution. The thermal behavior under oxidative and pyrolysis conditions was investigated employing thermogravimetry and differential thermal analysis (TG/DTG–DTA) and evolved gas analysis (EGA/TG-FTIR), and the complexes were characterized by elemental analysis (EA), EDTA complexometric titration, infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). By these results, the minimum formula was established as [M(Nor)2(H2O)2]·nH2O, where n = 3 (Ni), 2.5 (Mn Co, Zn), or 2 (Cu). The evolved gases identified during thermal decomposition of Ni and Cu complexes were ethylene, CO2 and CO for Ni; CO2 and ethane for Cu. Also, antimicrobial activity of the complexes was evaluated by in vitro susceptibility test using the agar diffusion method, and the results were compared with the uncomplexed molecule. It was found that norfloxacin complexation modifies its antibacterial activity. The activity depends on the type of metal ion and microorganism; Mn(II), Co(II) and Zn(II) complexes significantly increased activity against the tested gram-negative bacteria. |
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Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexesAntibacterial activityComplexesNorfloxacinThermal behaviorCoordination compounds of transition metals with norfloxacin (Nor) have potential to improve its effectiveness, as already discussed for some compounds found in the literature. The complexes in the solid state were prepared by precipitation of the respective metal cation (M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)) with a norfloxacin sodium salt solution. The thermal behavior under oxidative and pyrolysis conditions was investigated employing thermogravimetry and differential thermal analysis (TG/DTG–DTA) and evolved gas analysis (EGA/TG-FTIR), and the complexes were characterized by elemental analysis (EA), EDTA complexometric titration, infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). By these results, the minimum formula was established as [M(Nor)2(H2O)2]·nH2O, where n = 3 (Ni), 2.5 (Mn Co, Zn), or 2 (Cu). The evolved gases identified during thermal decomposition of Ni and Cu complexes were ethylene, CO2 and CO for Ni; CO2 and ethane for Cu. Also, antimicrobial activity of the complexes was evaluated by in vitro susceptibility test using the agar diffusion method, and the results were compared with the uncomplexed molecule. It was found that norfloxacin complexation modifies its antibacterial activity. The activity depends on the type of metal ion and microorganism; Mn(II), Co(II) and Zn(II) complexes significantly increased activity against the tested gram-negative bacteria.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto de Química Universidade Estadual Paulista (UNESP)Faculdade de Ciências Universidade Estadual Paulista (UNESP)Faculdade de Ciências Farmacêuticas Universidade Federal de Alfenas (UNIFAL-MG)Instituto de Ciência e Tecnologia Universidade Federal de Alfenas (UNIFAL-MG)Instituto de Química Universidade Estadual Paulista (UNESP)Faculdade de Ciências Universidade Estadual Paulista (UNESP)CNPq: 421469/2016-1Universidade Estadual Paulista (Unesp)Universidade Federal de Alfenas (UNIFAL-MG)Nunes, Wilhan Donizete Gonçalves [UNESP]do Nascimento, André Luiz Carneiro Soares [UNESP]Moura, Aniele [UNESP]Gaglieri, Caroline [UNESP]Vallim, Gustavo BrunelliNascimento, Luiz CarlosMendes, Roni AntônioIonashiro, Massao [UNESP]Caires, Flávio Junior [UNESP]2018-12-11T17:35:40Z2018-12-11T17:35:40Z2018-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1077-1088application/pdfhttp://dx.doi.org/10.1007/s10973-018-7019-zJournal of Thermal Analysis and Calorimetry, v. 132, n. 2, p. 1077-1088, 2018.1588-29261388-6150http://hdl.handle.net/11449/17955910.1007/s10973-018-7019-z2-s2.0-850414981302-s2.0-85041498130.pdf8460531302083773Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Thermal Analysis and Calorimetry0,5870,587info:eu-repo/semantics/openAccess2024-01-09T06:25:28Zoai:repositorio.unesp.br:11449/179559Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-09T06:25:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes |
title |
Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes |
spellingShingle |
Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes Nunes, Wilhan Donizete Gonçalves [UNESP] Antibacterial activity Complexes Norfloxacin Thermal behavior |
title_short |
Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes |
title_full |
Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes |
title_fullStr |
Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes |
title_full_unstemmed |
Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes |
title_sort |
Thermal, spectroscopic and antimicrobial activity characterization of some norfloxacin complexes |
author |
Nunes, Wilhan Donizete Gonçalves [UNESP] |
author_facet |
Nunes, Wilhan Donizete Gonçalves [UNESP] do Nascimento, André Luiz Carneiro Soares [UNESP] Moura, Aniele [UNESP] Gaglieri, Caroline [UNESP] Vallim, Gustavo Brunelli Nascimento, Luiz Carlos Mendes, Roni Antônio Ionashiro, Massao [UNESP] Caires, Flávio Junior [UNESP] |
author_role |
author |
author2 |
do Nascimento, André Luiz Carneiro Soares [UNESP] Moura, Aniele [UNESP] Gaglieri, Caroline [UNESP] Vallim, Gustavo Brunelli Nascimento, Luiz Carlos Mendes, Roni Antônio Ionashiro, Massao [UNESP] Caires, Flávio Junior [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Alfenas (UNIFAL-MG) |
dc.contributor.author.fl_str_mv |
Nunes, Wilhan Donizete Gonçalves [UNESP] do Nascimento, André Luiz Carneiro Soares [UNESP] Moura, Aniele [UNESP] Gaglieri, Caroline [UNESP] Vallim, Gustavo Brunelli Nascimento, Luiz Carlos Mendes, Roni Antônio Ionashiro, Massao [UNESP] Caires, Flávio Junior [UNESP] |
dc.subject.por.fl_str_mv |
Antibacterial activity Complexes Norfloxacin Thermal behavior |
topic |
Antibacterial activity Complexes Norfloxacin Thermal behavior |
description |
Coordination compounds of transition metals with norfloxacin (Nor) have potential to improve its effectiveness, as already discussed for some compounds found in the literature. The complexes in the solid state were prepared by precipitation of the respective metal cation (M = Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)) with a norfloxacin sodium salt solution. The thermal behavior under oxidative and pyrolysis conditions was investigated employing thermogravimetry and differential thermal analysis (TG/DTG–DTA) and evolved gas analysis (EGA/TG-FTIR), and the complexes were characterized by elemental analysis (EA), EDTA complexometric titration, infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). By these results, the minimum formula was established as [M(Nor)2(H2O)2]·nH2O, where n = 3 (Ni), 2.5 (Mn Co, Zn), or 2 (Cu). The evolved gases identified during thermal decomposition of Ni and Cu complexes were ethylene, CO2 and CO for Ni; CO2 and ethane for Cu. Also, antimicrobial activity of the complexes was evaluated by in vitro susceptibility test using the agar diffusion method, and the results were compared with the uncomplexed molecule. It was found that norfloxacin complexation modifies its antibacterial activity. The activity depends on the type of metal ion and microorganism; Mn(II), Co(II) and Zn(II) complexes significantly increased activity against the tested gram-negative bacteria. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:35:40Z 2018-12-11T17:35:40Z 2018-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10973-018-7019-z Journal of Thermal Analysis and Calorimetry, v. 132, n. 2, p. 1077-1088, 2018. 1588-2926 1388-6150 http://hdl.handle.net/11449/179559 10.1007/s10973-018-7019-z 2-s2.0-85041498130 2-s2.0-85041498130.pdf 8460531302083773 |
url |
http://dx.doi.org/10.1007/s10973-018-7019-z http://hdl.handle.net/11449/179559 |
identifier_str_mv |
Journal of Thermal Analysis and Calorimetry, v. 132, n. 2, p. 1077-1088, 2018. 1588-2926 1388-6150 10.1007/s10973-018-7019-z 2-s2.0-85041498130 2-s2.0-85041498130.pdf 8460531302083773 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Thermal Analysis and Calorimetry 0,587 0,587 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1077-1088 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803047295844876288 |