Treinamento aeróbio e diabetes experimental em ratos: perfil endócrino-metabólico no cerebelo

• Autor(a) principal: Arantes, Luciana Mendonça [UNESP]
• Data de Publicação: 2013
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/108749
• topic: Sports medicine; Medicina esportiva; Glicemia; Morfologia (Animais); Cerebelo; Insulina; Exercícios aeróbicos; Fisiologia; Diabetes

This study had been designed to evaluate the aerobic exercise training effects on endocrine- metabolic profile of diabetic rats, with greater emphasis in the cerebellum. Therefore, adult Wistar rats had been submitted to induction by injecting alloxan monohydrate. Five days after the drug administration, a blood glucose test was performed for proving the glucose diabetic state of the animals, being considered diabetic only those rats which had shown blood glucose equal or higher than 250 mg per 100 ml of blood. After the finding of diabetes, the rats were divided randomly into four groups: Sedentary Control (SC) - control rats which did not engage in physical exercise; Trained Control (TC) - control rats which were submitted to the physical exercise protocol; Sedentary Diabetic (SD) - alloxan diabetic rats which were not submitted to the physical exercise protocol; Trained Diabetic (TD) - alloxan diabetic rats that were submitted to the same physical exercise protocol group of the trained control group (TC). The physical exercise training protocol had been consisted of swimming for 1 hour / day, 5 times / week during 8 consecutive weeks and with an overload, attached to the chest, corresponding to the maximum lactate steady state, in % of the body weight. The values of the blood glucose and triglycerides were increased in diabetic animals (SD and TD) and both were reduced in the trained diabetic group when compared to the sedentary diabetic group values. The inducing of diabetes reduced the insulin values in the animals of both groups (SD and TD), and the physical exercise training has not changed the values of this parameter. The aerobic training did not affect the concentrations of IGF-1 and insulin in the cerebellum. Differences had been observed in the body balance of the diabetic rats and control group. The diabetic group had shown lower performance than the control group, presenting greater difficulty in the activities that require...