Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bbadis.2021.166285 http://hdl.handle.net/11449/222627 |
Resumo: | During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level. |
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Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseasesBacteriaMaternal-fetal interphaseMycoplasmaNeonatesPregnancyVirusesDuring pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.Agencia Nacional de Investigación e InnovaciónComisión Sectorial de Investigación CientíficaRijksuniversiteit GroningenUniversidad de la República UruguayFondo Nacional de Desarrollo Científico y TecnológicoLaboratory of Ion Channels Biological Membranes and Cell Signaling Dept. of Biophysics Facultad de Medicina Universidad de la RepublicaDept. of Neonatology Facultad de Medicina Universidad de la RepublicaDept. of Histology and Development Facultad de Medicina Universidad de la RepublicaDept. of Clinical Ginecology and Obstetrics B Facultad de Medicina Universidad de la RepublicaCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de ChileDepartment of Physiology Faculty of Pharmacy Universidad de SevillaMedical School Faculty of Medicine Sao Paulo State University (UNESP)University of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of QueenslandDepartment of Pathology and Medical Biology University of Groningen University Medical Center GroningenDepartment of Molecular Pathology The Institute for Molecular MedicineMedical School Faculty of Medicine Sao Paulo State University (UNESP)Fondo Nacional de Desarrollo Científico y Tecnológico: 1190316Universidad de la RepublicaPontificia Universidad Católica de ChileUniversidad de SevillaUniversidade Estadual Paulista (UNESP)University of QueenslandUniversity Medical Center GroningenThe Institute for Molecular MedicineFerreira, GonzaloBlasina, FernandaRodríguez Rey, MarianelaAnesetti, GabrielSapiro, RosanaChavarría, LuisinaCardozo, RominaRey, GrazziaSobrevia, Luis [UNESP]Nicolson, Garth L.2022-04-28T19:45:52Z2022-04-28T19:45:52Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bbadis.2021.166285Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1868, n. 1, 2022.1879-260X0925-4439http://hdl.handle.net/11449/22262710.1016/j.bbadis.2021.1662852-s2.0-85116931951Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiochimica et Biophysica Acta - Molecular Basis of Diseaseinfo:eu-repo/semantics/openAccess2022-04-28T19:45:52Zoai:repositorio.unesp.br:11449/222627Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:58:12.077158Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases |
title |
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases |
spellingShingle |
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases Ferreira, Gonzalo Bacteria Maternal-fetal interphase Mycoplasma Neonates Pregnancy Viruses |
title_short |
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases |
title_full |
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases |
title_fullStr |
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases |
title_full_unstemmed |
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases |
title_sort |
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases |
author |
Ferreira, Gonzalo |
author_facet |
Ferreira, Gonzalo Blasina, Fernanda Rodríguez Rey, Marianela Anesetti, Gabriel Sapiro, Rosana Chavarría, Luisina Cardozo, Romina Rey, Grazzia Sobrevia, Luis [UNESP] Nicolson, Garth L. |
author_role |
author |
author2 |
Blasina, Fernanda Rodríguez Rey, Marianela Anesetti, Gabriel Sapiro, Rosana Chavarría, Luisina Cardozo, Romina Rey, Grazzia Sobrevia, Luis [UNESP] Nicolson, Garth L. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidad de la Republica Pontificia Universidad Católica de Chile Universidad de Sevilla Universidade Estadual Paulista (UNESP) University of Queensland University Medical Center Groningen The Institute for Molecular Medicine |
dc.contributor.author.fl_str_mv |
Ferreira, Gonzalo Blasina, Fernanda Rodríguez Rey, Marianela Anesetti, Gabriel Sapiro, Rosana Chavarría, Luisina Cardozo, Romina Rey, Grazzia Sobrevia, Luis [UNESP] Nicolson, Garth L. |
dc.subject.por.fl_str_mv |
Bacteria Maternal-fetal interphase Mycoplasma Neonates Pregnancy Viruses |
topic |
Bacteria Maternal-fetal interphase Mycoplasma Neonates Pregnancy Viruses |
description |
During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-28T19:45:52Z 2022-04-28T19:45:52Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bbadis.2021.166285 Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1868, n. 1, 2022. 1879-260X 0925-4439 http://hdl.handle.net/11449/222627 10.1016/j.bbadis.2021.166285 2-s2.0-85116931951 |
url |
http://dx.doi.org/10.1016/j.bbadis.2021.166285 http://hdl.handle.net/11449/222627 |
identifier_str_mv |
Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1868, n. 1, 2022. 1879-260X 0925-4439 10.1016/j.bbadis.2021.166285 2-s2.0-85116931951 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biochimica et Biophysica Acta - Molecular Basis of Disease |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129379509731328 |