Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases

Detalhes bibliográficos
Autor(a) principal: Ferreira, Gonzalo
Data de Publicação: 2022
Outros Autores: Blasina, Fernanda, Rodríguez Rey, Marianela, Anesetti, Gabriel, Sapiro, Rosana, Chavarría, Luisina, Cardozo, Romina, Rey, Grazzia, Sobrevia, Luis [UNESP], Nicolson, Garth L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.bbadis.2021.166285
http://hdl.handle.net/11449/222627
Resumo: During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.
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spelling Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseasesBacteriaMaternal-fetal interphaseMycoplasmaNeonatesPregnancyVirusesDuring pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.Agencia Nacional de Investigación e InnovaciónComisión Sectorial de Investigación CientíficaRijksuniversiteit GroningenUniversidad de la República UruguayFondo Nacional de Desarrollo Científico y TecnológicoLaboratory of Ion Channels Biological Membranes and Cell Signaling Dept. of Biophysics Facultad de Medicina Universidad de la RepublicaDept. of Neonatology Facultad de Medicina Universidad de la RepublicaDept. of Histology and Development Facultad de Medicina Universidad de la RepublicaDept. of Clinical Ginecology and Obstetrics B Facultad de Medicina Universidad de la RepublicaCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de ChileDepartment of Physiology Faculty of Pharmacy Universidad de SevillaMedical School Faculty of Medicine Sao Paulo State University (UNESP)University of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of QueenslandDepartment of Pathology and Medical Biology University of Groningen University Medical Center GroningenDepartment of Molecular Pathology The Institute for Molecular MedicineMedical School Faculty of Medicine Sao Paulo State University (UNESP)Fondo Nacional de Desarrollo Científico y Tecnológico: 1190316Universidad de la RepublicaPontificia Universidad Católica de ChileUniversidad de SevillaUniversidade Estadual Paulista (UNESP)University of QueenslandUniversity Medical Center GroningenThe Institute for Molecular MedicineFerreira, GonzaloBlasina, FernandaRodríguez Rey, MarianelaAnesetti, GabrielSapiro, RosanaChavarría, LuisinaCardozo, RominaRey, GrazziaSobrevia, Luis [UNESP]Nicolson, Garth L.2022-04-28T19:45:52Z2022-04-28T19:45:52Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bbadis.2021.166285Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1868, n. 1, 2022.1879-260X0925-4439http://hdl.handle.net/11449/22262710.1016/j.bbadis.2021.1662852-s2.0-85116931951Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiochimica et Biophysica Acta - Molecular Basis of Diseaseinfo:eu-repo/semantics/openAccess2022-04-28T19:45:52Zoai:repositorio.unesp.br:11449/222627Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:58:12.077158Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
title Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
spellingShingle Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
Ferreira, Gonzalo
Bacteria
Maternal-fetal interphase
Mycoplasma
Neonates
Pregnancy
Viruses
title_short Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
title_full Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
title_fullStr Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
title_full_unstemmed Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
title_sort Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
author Ferreira, Gonzalo
author_facet Ferreira, Gonzalo
Blasina, Fernanda
Rodríguez Rey, Marianela
Anesetti, Gabriel
Sapiro, Rosana
Chavarría, Luisina
Cardozo, Romina
Rey, Grazzia
Sobrevia, Luis [UNESP]
Nicolson, Garth L.
author_role author
author2 Blasina, Fernanda
Rodríguez Rey, Marianela
Anesetti, Gabriel
Sapiro, Rosana
Chavarría, Luisina
Cardozo, Romina
Rey, Grazzia
Sobrevia, Luis [UNESP]
Nicolson, Garth L.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de la Republica
Pontificia Universidad Católica de Chile
Universidad de Sevilla
Universidade Estadual Paulista (UNESP)
University of Queensland
University Medical Center Groningen
The Institute for Molecular Medicine
dc.contributor.author.fl_str_mv Ferreira, Gonzalo
Blasina, Fernanda
Rodríguez Rey, Marianela
Anesetti, Gabriel
Sapiro, Rosana
Chavarría, Luisina
Cardozo, Romina
Rey, Grazzia
Sobrevia, Luis [UNESP]
Nicolson, Garth L.
dc.subject.por.fl_str_mv Bacteria
Maternal-fetal interphase
Mycoplasma
Neonates
Pregnancy
Viruses
topic Bacteria
Maternal-fetal interphase
Mycoplasma
Neonates
Pregnancy
Viruses
description During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the infections in this and the companion review. Particular situations increase susceptibility to infection in neonates. The enhanced susceptibility to certain infections increases the risk of developing particular diseases that can progress to become morbidly severe. For example, during the current pandemic caused by the SARS-CoV-2 virus, epidemiological studies have established that pregnant women with COVID-19 disease are more likely to be hospitalized. However, the risk for intensive care unit admission and mechanical ventilation is not increased compared with nonpregnant women. Although much remains unknown with this particular infection, the elevated risk of progression during pregnancy towards more severe manifestations of COVID-19 disease is not associated with an increased risk of death. In addition, the epidemiological data available in neonates suggest that their risk of acquiring COVID-19 is low compared with infants (<12 months of age). However, they might be at higher risk for progression to severe COVID-19 disease compared with older children. The data on clinical presentation and disease severity among neonates are limited and based on case reports and small case series. It is well documented the importance of the Zika virus infection as the main cause of several congenital anomalies and birth defects such as microcephaly, and also adverse pregnancy outcomes. Mycoplasma infections also increase adverse pregnancy outcomes. This review will focus on the molecular, pathophysiological and biophysical characteristics of the mother/placental-fetal/neonatal interactions and the possible mechanisms of these pathogens (SARS-CoV-2, ZIKV, and Mycoplasmas) for promoting disease at this level.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-28T19:45:52Z
2022-04-28T19:45:52Z
2022-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.bbadis.2021.166285
Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1868, n. 1, 2022.
1879-260X
0925-4439
http://hdl.handle.net/11449/222627
10.1016/j.bbadis.2021.166285
2-s2.0-85116931951
url http://dx.doi.org/10.1016/j.bbadis.2021.166285
http://hdl.handle.net/11449/222627
identifier_str_mv Biochimica et Biophysica Acta - Molecular Basis of Disease, v. 1868, n. 1, 2022.
1879-260X
0925-4439
10.1016/j.bbadis.2021.166285
2-s2.0-85116931951
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochimica et Biophysica Acta - Molecular Basis of Disease
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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