Serotonin and the control of eupneic breathing
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Tipo de documento: | Capítulo de livro |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/B978-0-12-800050-2.00019-X http://hdl.handle.net/11449/198582 |
Resumo: | The mechanisms responsible for respiratory rhythm and pattern generation are continuously tuned by neuromodulators. Serotonin is a powerful modulator of the respiratory network that regulates synaptic and intrinsic properties of respiratory neurons that, in turn, may differentially affect the frequency and amplitude of respiratory activity. Serotonin is also required for central respiratory chemoreception and the development of some forms of respiratory neuroplasticity. Because of the complexity of serotoninergic system (excitatory and inhibitory actions) and the diversity of respiratory neurons that express serotoninergic receptors, several questions about the action mechanisms of serotonin in the respiratory network remain unanswered. However, studies showing that disruption of serotoninergic control of respiratory network causes respiratory instability or disease, support the notion that this neuromodulator is necessary for the control of eupneic breathing. |
id |
UNSP_e647d47c178616bf8017279fb3f6f7f1 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/198582 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Serotonin and the control of eupneic breathing5-HT receptorsBrainstemPlasticitySerotoninThe mechanisms responsible for respiratory rhythm and pattern generation are continuously tuned by neuromodulators. Serotonin is a powerful modulator of the respiratory network that regulates synaptic and intrinsic properties of respiratory neurons that, in turn, may differentially affect the frequency and amplitude of respiratory activity. Serotonin is also required for central respiratory chemoreception and the development of some forms of respiratory neuroplasticity. Because of the complexity of serotoninergic system (excitatory and inhibitory actions) and the diversity of respiratory neurons that express serotoninergic receptors, several questions about the action mechanisms of serotonin in the respiratory network remain unanswered. However, studies showing that disruption of serotoninergic control of respiratory network causes respiratory instability or disease, support the notion that this neuromodulator is necessary for the control of eupneic breathing.Department of Physiology and Pathology São Paulo State University (UNESP)Department of Physiology and Pathology São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Zoccal, Daniel B. [UNESP]2020-12-12T01:16:46Z2020-12-12T01:16:46Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart391-403http://dx.doi.org/10.1016/B978-0-12-800050-2.00019-XSerotonin: The Mediator that Spans Evolution, p. 391-403.http://hdl.handle.net/11449/19858210.1016/B978-0-12-800050-2.00019-X2-s2.0-85080817529Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSerotonin: The Mediator that Spans Evolutioninfo:eu-repo/semantics/openAccess2021-10-22T17:11:17Zoai:repositorio.unesp.br:11449/198582Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:41:23.793074Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Serotonin and the control of eupneic breathing |
title |
Serotonin and the control of eupneic breathing |
spellingShingle |
Serotonin and the control of eupneic breathing Zoccal, Daniel B. [UNESP] 5-HT receptors Brainstem Plasticity Serotonin |
title_short |
Serotonin and the control of eupneic breathing |
title_full |
Serotonin and the control of eupneic breathing |
title_fullStr |
Serotonin and the control of eupneic breathing |
title_full_unstemmed |
Serotonin and the control of eupneic breathing |
title_sort |
Serotonin and the control of eupneic breathing |
author |
Zoccal, Daniel B. [UNESP] |
author_facet |
Zoccal, Daniel B. [UNESP] |
author_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Zoccal, Daniel B. [UNESP] |
dc.subject.por.fl_str_mv |
5-HT receptors Brainstem Plasticity Serotonin |
topic |
5-HT receptors Brainstem Plasticity Serotonin |
description |
The mechanisms responsible for respiratory rhythm and pattern generation are continuously tuned by neuromodulators. Serotonin is a powerful modulator of the respiratory network that regulates synaptic and intrinsic properties of respiratory neurons that, in turn, may differentially affect the frequency and amplitude of respiratory activity. Serotonin is also required for central respiratory chemoreception and the development of some forms of respiratory neuroplasticity. Because of the complexity of serotoninergic system (excitatory and inhibitory actions) and the diversity of respiratory neurons that express serotoninergic receptors, several questions about the action mechanisms of serotonin in the respiratory network remain unanswered. However, studies showing that disruption of serotoninergic control of respiratory network causes respiratory instability or disease, support the notion that this neuromodulator is necessary for the control of eupneic breathing. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 2020-12-12T01:16:46Z 2020-12-12T01:16:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bookPart |
format |
bookPart |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/B978-0-12-800050-2.00019-X Serotonin: The Mediator that Spans Evolution, p. 391-403. http://hdl.handle.net/11449/198582 10.1016/B978-0-12-800050-2.00019-X 2-s2.0-85080817529 |
url |
http://dx.doi.org/10.1016/B978-0-12-800050-2.00019-X http://hdl.handle.net/11449/198582 |
identifier_str_mv |
Serotonin: The Mediator that Spans Evolution, p. 391-403. 10.1016/B978-0-12-800050-2.00019-X 2-s2.0-85080817529 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Serotonin: The Mediator that Spans Evolution |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
391-403 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129346507898880 |