Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/aor.13624 http://hdl.handle.net/11449/201517 |
Resumo: | Titanium alloys are widely used in the biomedical field due to their excellent resistance to corrosion, high mechanical strength/density ratio, low elastic modulus, and good biocompatibility. Niobium is a β-stabilizer element that has the potential to decrease elastic modulus and possesses excellent corrosion resistance. In this article, Ti-15Nb alloy was prepared via arc-melting, with the aim of using it in biomedical applications to replace implants that fail due to mechanical incompatibility with human bone. This Ti-15Nb alloy was structurally, chemically, and microstructurally characterized. Its mechanical properties were analyzed via Vickers microhardness and elastic modulus measurements. The cytotoxicity of the alloy was evaluated via direct and indirect MTT tests. In the direct MTT test, the cells were grown on alloy and in the indirect test, Ti-15Nb alloy extracts were prepared (1 g/1 mL at 310 K for 48 hours). The results of chemical composition showed that the alloy produced has good quality and low content of gaseous impurities, such as oxygen and nitrogen. The obtained results for structure and microstructure indicated the presence of the martensite α’ phase. The microhardness of the Ti-15Nb alloy is superior to that of cp-Ti due to solid solution hardening, and the alloy has a better elastic modulus as compared to pure titanium. Cytotoxic effects were not observed. The Ti-15Nb alloy shows good results of mechanical properties and does not show cytotoxic effects. In addition, morphological variations were not found in the cells and good cell adhesion in all the studied conditions was observed. In general, the alloy proposed in this article has satisfactory characteristics as a biomedical material. |
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Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applicationsbiomaterialcharacterizationcytotoxicityTi alloysTitanium alloys are widely used in the biomedical field due to their excellent resistance to corrosion, high mechanical strength/density ratio, low elastic modulus, and good biocompatibility. Niobium is a β-stabilizer element that has the potential to decrease elastic modulus and possesses excellent corrosion resistance. In this article, Ti-15Nb alloy was prepared via arc-melting, with the aim of using it in biomedical applications to replace implants that fail due to mechanical incompatibility with human bone. This Ti-15Nb alloy was structurally, chemically, and microstructurally characterized. Its mechanical properties were analyzed via Vickers microhardness and elastic modulus measurements. The cytotoxicity of the alloy was evaluated via direct and indirect MTT tests. In the direct MTT test, the cells were grown on alloy and in the indirect test, Ti-15Nb alloy extracts were prepared (1 g/1 mL at 310 K for 48 hours). The results of chemical composition showed that the alloy produced has good quality and low content of gaseous impurities, such as oxygen and nitrogen. The obtained results for structure and microstructure indicated the presence of the martensite α’ phase. The microhardness of the Ti-15Nb alloy is superior to that of cp-Ti due to solid solution hardening, and the alloy has a better elastic modulus as compared to pure titanium. Cytotoxic effects were not observed. The Ti-15Nb alloy shows good results of mechanical properties and does not show cytotoxic effects. In addition, morphological variations were not found in the cells and good cell adhesion in all the studied conditions was observed. In general, the alloy proposed in this article has satisfactory characteristics as a biomedical material.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Laboratório de Anelasticidade e Biomateriais UNESP - Univ Estadual PaulistaIBTN-Br – Institute of Biomaterials Tribocorrosion and Nanomedicine – Brazilian BranchLaboratório de Anelasticidade e Biomateriais UNESP - Univ Estadual PaulistaFAPESP: 2009/16.731-9FAPESP: 2015/09.480-0FAPESP: 2015/25.562-7CNPq: 308.204/2017-4CNPq: 400.705/2015-0Universidade Estadual Paulista (Unesp)Tribocorrosion and Nanomedicine – Brazilian BranchKuroda, Pedro Akira Bazaglia [UNESP]da Silva, Luciano Monteiro [UNESP]Sousa, Karolyne dos Santos Jorge [UNESP]Donato, Tatiani Ayako Goto [UNESP]Grandini, Carlos Roberto [UNESP]2020-12-12T02:34:35Z2020-12-12T02:34:35Z2020-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article811-817http://dx.doi.org/10.1111/aor.13624Artificial Organs, v. 44, n. 8, p. 811-817, 2020.1525-15940160-564Xhttp://hdl.handle.net/11449/20151710.1111/aor.136242-s2.0-85078857658Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArtificial Organsinfo:eu-repo/semantics/openAccess2024-04-25T17:40:30Zoai:repositorio.unesp.br:11449/201517Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:34:38.162671Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applications |
title |
Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applications |
spellingShingle |
Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applications Kuroda, Pedro Akira Bazaglia [UNESP] biomaterial characterization cytotoxicity Ti alloys |
title_short |
Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applications |
title_full |
Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applications |
title_fullStr |
Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applications |
title_full_unstemmed |
Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applications |
title_sort |
Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti-15Nb alloy for biomedical applications |
author |
Kuroda, Pedro Akira Bazaglia [UNESP] |
author_facet |
Kuroda, Pedro Akira Bazaglia [UNESP] da Silva, Luciano Monteiro [UNESP] Sousa, Karolyne dos Santos Jorge [UNESP] Donato, Tatiani Ayako Goto [UNESP] Grandini, Carlos Roberto [UNESP] |
author_role |
author |
author2 |
da Silva, Luciano Monteiro [UNESP] Sousa, Karolyne dos Santos Jorge [UNESP] Donato, Tatiani Ayako Goto [UNESP] Grandini, Carlos Roberto [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Tribocorrosion and Nanomedicine – Brazilian Branch |
dc.contributor.author.fl_str_mv |
Kuroda, Pedro Akira Bazaglia [UNESP] da Silva, Luciano Monteiro [UNESP] Sousa, Karolyne dos Santos Jorge [UNESP] Donato, Tatiani Ayako Goto [UNESP] Grandini, Carlos Roberto [UNESP] |
dc.subject.por.fl_str_mv |
biomaterial characterization cytotoxicity Ti alloys |
topic |
biomaterial characterization cytotoxicity Ti alloys |
description |
Titanium alloys are widely used in the biomedical field due to their excellent resistance to corrosion, high mechanical strength/density ratio, low elastic modulus, and good biocompatibility. Niobium is a β-stabilizer element that has the potential to decrease elastic modulus and possesses excellent corrosion resistance. In this article, Ti-15Nb alloy was prepared via arc-melting, with the aim of using it in biomedical applications to replace implants that fail due to mechanical incompatibility with human bone. This Ti-15Nb alloy was structurally, chemically, and microstructurally characterized. Its mechanical properties were analyzed via Vickers microhardness and elastic modulus measurements. The cytotoxicity of the alloy was evaluated via direct and indirect MTT tests. In the direct MTT test, the cells were grown on alloy and in the indirect test, Ti-15Nb alloy extracts were prepared (1 g/1 mL at 310 K for 48 hours). The results of chemical composition showed that the alloy produced has good quality and low content of gaseous impurities, such as oxygen and nitrogen. The obtained results for structure and microstructure indicated the presence of the martensite α’ phase. The microhardness of the Ti-15Nb alloy is superior to that of cp-Ti due to solid solution hardening, and the alloy has a better elastic modulus as compared to pure titanium. Cytotoxic effects were not observed. The Ti-15Nb alloy shows good results of mechanical properties and does not show cytotoxic effects. In addition, morphological variations were not found in the cells and good cell adhesion in all the studied conditions was observed. In general, the alloy proposed in this article has satisfactory characteristics as a biomedical material. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:34:35Z 2020-12-12T02:34:35Z 2020-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/aor.13624 Artificial Organs, v. 44, n. 8, p. 811-817, 2020. 1525-1594 0160-564X http://hdl.handle.net/11449/201517 10.1111/aor.13624 2-s2.0-85078857658 |
url |
http://dx.doi.org/10.1111/aor.13624 http://hdl.handle.net/11449/201517 |
identifier_str_mv |
Artificial Organs, v. 44, n. 8, p. 811-817, 2020. 1525-1594 0160-564X 10.1111/aor.13624 2-s2.0-85078857658 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Artificial Organs |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
811-817 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129531964293120 |