Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1590/0037-8682-0302-2016 http://hdl.handle.net/11449/162579 |
Resumo: | Introduction: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. Methods: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. Results: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. Conclusions: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis. |
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Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis CHepatic fibrosisPDGFTGFBIntroduction: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. Methods: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. Results: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. Conclusions: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis.Univ Estadual Paulista, Programa Posgrad Stricto Sensu Fisiopatol Clin Me, Fac Med Botucatu, Sao Paulo, BrazilUniv Estadual Paulista, Lab Biol Mol Hemoctr, Fac Med Botucatu, Sao Paulo, BrazilUniv Estadual Paulista, Dept Bioproc & Biotecnol, Fac Ciencias Agron, Sao Paulo, BrazilUniv Estadual Paulista, Dept Clin Med, Fac Med Botucatu, Sao Paulo, BrazilUniv Estadual Paulista, Programa Posgrad Stricto Sensu Fisiopatol Clin Me, Fac Med Botucatu, Sao Paulo, BrazilUniv Estadual Paulista, Lab Biol Mol Hemoctr, Fac Med Botucatu, Sao Paulo, BrazilUniv Estadual Paulista, Dept Bioproc & Biotecnol, Fac Ciencias Agron, Sao Paulo, BrazilUniv Estadual Paulista, Dept Clin Med, Fac Med Botucatu, Sao Paulo, BrazilSoc Brasileira Medicina TropicalUniversidade Estadual Paulista (Unesp)Tanikawa, Aline Aki [UNESP]Tommasini Grotto, Rejane Maria [UNESP]Silva, Giovanni Faria [UNESP]Ferrasi, Adriana Camargo [UNESP]Rodrigues Sarnighausen, Valeria Cristina [UNESP]Moura Campos Pardini, Maria Ines de [UNESP]2018-11-26T17:21:00Z2018-11-26T17:21:00Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article113-116application/pdfhttp://dx.doi.org/10.1590/0037-8682-0302-2016Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 50, n. 1, p. 113-116, 2017.0037-8682http://hdl.handle.net/11449/16257910.1590/0037-8682-0302-2016S0037-86822017000100113WOS:000396497600018S0037-86822017000100113.pdf35878950852262240000-0001-9200-5391Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Da Sociedade Brasileira De Medicina Tropical0,658info:eu-repo/semantics/openAccess2024-09-03T13:14:19Zoai:repositorio.unesp.br:11449/162579Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:19Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
| title |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
| spellingShingle |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C Tanikawa, Aline Aki [UNESP] Hepatic fibrosis PDGF TGFB |
| title_short |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
| title_full |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
| title_fullStr |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
| title_full_unstemmed |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
| title_sort |
Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C |
| author |
Tanikawa, Aline Aki [UNESP] |
| author_facet |
Tanikawa, Aline Aki [UNESP] Tommasini Grotto, Rejane Maria [UNESP] Silva, Giovanni Faria [UNESP] Ferrasi, Adriana Camargo [UNESP] Rodrigues Sarnighausen, Valeria Cristina [UNESP] Moura Campos Pardini, Maria Ines de [UNESP] |
| author_role |
author |
| author2 |
Tommasini Grotto, Rejane Maria [UNESP] Silva, Giovanni Faria [UNESP] Ferrasi, Adriana Camargo [UNESP] Rodrigues Sarnighausen, Valeria Cristina [UNESP] Moura Campos Pardini, Maria Ines de [UNESP] |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
| dc.contributor.author.fl_str_mv |
Tanikawa, Aline Aki [UNESP] Tommasini Grotto, Rejane Maria [UNESP] Silva, Giovanni Faria [UNESP] Ferrasi, Adriana Camargo [UNESP] Rodrigues Sarnighausen, Valeria Cristina [UNESP] Moura Campos Pardini, Maria Ines de [UNESP] |
| dc.subject.por.fl_str_mv |
Hepatic fibrosis PDGF TGFB |
| topic |
Hepatic fibrosis PDGF TGFB |
| description |
Introduction: Transforming growth factor beta 1 (TGFB1) and platelet-derived growth factor (PDGF) are the main cytokines related to hepatic fibrogenesis. Methods: RNA isolated from the platelets and hepatic tissue of 43 HCV carriers was used for quantitative polymerase chain reaction to determine TGFB1, PDGFA, and PDGFB RNA expression. Results: The mRNA expression of PDGFA in platelets was significantly lower in the group with advanced fibrosis than in the group with early-stage fibrosis. TGFB1 was more frequently expressed in platelets than in hepatic tissue, which was different from PDGFB. Conclusions: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-01-01 2018-11-26T17:21:00Z 2018-11-26T17:21:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0037-8682-0302-2016 Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 50, n. 1, p. 113-116, 2017. 0037-8682 http://hdl.handle.net/11449/162579 10.1590/0037-8682-0302-2016 S0037-86822017000100113 WOS:000396497600018 S0037-86822017000100113.pdf 3587895085226224 0000-0001-9200-5391 |
| url |
http://dx.doi.org/10.1590/0037-8682-0302-2016 http://hdl.handle.net/11449/162579 |
| identifier_str_mv |
Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 50, n. 1, p. 113-116, 2017. 0037-8682 10.1590/0037-8682-0302-2016 S0037-86822017000100113 WOS:000396497600018 S0037-86822017000100113.pdf 3587895085226224 0000-0001-9200-5391 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Revista Da Sociedade Brasileira De Medicina Tropical 0,658 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
113-116 application/pdf |
| dc.publisher.none.fl_str_mv |
Soc Brasileira Medicina Tropical |
| publisher.none.fl_str_mv |
Soc Brasileira Medicina Tropical |
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Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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repositoriounesp@unesp.br |
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1810021360137666560 |