Correlação da presença do papilomavírus humano (HPV) e o vírus Epstein-Barr (EBV) em pacientes portadores de carcinoma espinocelular de orofaringe: análise de sobrevida

• Autor(a) principal: Soares, Gláucia Resende [UNESP]
• Data de Publicação: 2011
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/155171; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-04-25/000879808.pdf
• topic: Herpesvirus humano 4; Papillomaviridae; Carcinoma de células escamosas; Reação em cadeia da polimerase; Herpesvirus 4, Human

The human papillomavirus (HPV) is considered the mainly etiologic factor of cervical cancer and his role in oropharynx squamous cell carcinoma is much studied. Epstein-Barr virus (EBV) affects 90% of the world population, being highly associated with some types of cancer and immunosuppression, however its direct relationship to oral carcinomas has not been fully proven. The aim of this study is to measure the presence of HPV and EBV in paraffin embedded samples obtained by biopsy of patients with oropharynx squamous cell carcinoma, correlate the presence of these viruses among themselves and each one in relation to survival. Virus detection was performed using the polymerase chain reaction (PCR) in 37 paraffin sample of oropharynx squamous cell carcinoma, and found 12 (32.4%) samples with HPV positive, three (8.1% ) EBV positive and no samples contained the two viral ADN. The results were subjected to statistical analysis (chi-square or Fisher's exact test) and for the survival analysis was applied the test of Kaplan Meier. There was no statistical significance between the variables. The non-correlation of the presence of HPV and EBV suggests that these viruses act independently from each other in the development of squamous cell carcinoma of the oropharynx