HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2018/3830104 http://hdl.handle.net/11449/164653 |
Resumo: | Purpose. Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and HLA-C alleles have been associated with AIDS disease outcome, we typed HLA-C locus in patients with AIDS exhibiting or not CR. Methods. Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). HLA-C typing was performed using commercial kits. Results. The H LA-C*07 allele group was underrepresented in AIDS patients with CR (P = 0.005) when compared to controls or when compared to AIDS patients without CR (P = 0.006). The IILA-C*05 allele group was overrepresented in Group II in comparison to Group III (P = 0.017). The frequency of the HLA-C* 16 allele group was increased in Group III in comparison to Group II (P = 0.004). Conclusion. The HLA-C*07 allele group conferred protection against the development of CR in Brazilian AIDS patients, whereas the HLA-C*05 and HLA-C*16 allele groups were associated with AIDS susceptibility or protection, respectively. |
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HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDSPurpose. Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and HLA-C alleles have been associated with AIDS disease outcome, we typed HLA-C locus in patients with AIDS exhibiting or not CR. Methods. Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). HLA-C typing was performed using commercial kits. Results. The H LA-C*07 allele group was underrepresented in AIDS patients with CR (P = 0.005) when compared to controls or when compared to AIDS patients without CR (P = 0.006). The IILA-C*05 allele group was overrepresented in Group II in comparison to Group III (P = 0.017). The frequency of the HLA-C* 16 allele group was increased in Group III in comparison to Group II (P = 0.004). Conclusion. The HLA-C*07 allele group conferred protection against the development of CR in Brazilian AIDS patients, whereas the HLA-C*05 and HLA-C*16 allele groups were associated with AIDS susceptibility or protection, respectively.Foundation for Support of Teaching, Research and Assistance (FAEPA)Univ Sao Paulo, Ribeirao Preto Med Sch, Univ Dev Pantanal Reg UNIDERP, Sao Paulo, SP, BrazilUniv Sao Paulo, Ribeirao Preto Med Sch, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Sao Paulo, SP, BrazilUniv Sao Paulo, Nursing Sch Ribeirao Preto, Dept Gen & Specialized Nursing, Sao Paulo, SP, BrazilUniv Hosp, Ribeirao Preto Med Sch, Mol Immunol Lab, Ribeirao Preto, BrazilUniv Hosp, Ribeirao Preto Med Sch, HLA Hemoctr, Ribeirao Preto, BrazilSao Paulo State Univ, Sch Med, Dept Pathol & Mol Genet, Botucatu, SP, BrazilSao Paulo State Univ, Bioinformat Lab, Botucatu, SP, BrazilUniv Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Lab Pesquisas Forenses & Genom, BR-14040901 Ribeirao Preto, SP, BrazilUniv Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Div Immunol, Sao Paulo, SP, BrazilSao Paulo State Univ, Sch Med, Dept Pathol & Mol Genet, Botucatu, SP, BrazilSao Paulo State Univ, Bioinformat Lab, Botucatu, SP, BrazilHindawi LtdUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Biberg-Salum, Tania GiselaVeronese Rodrigues, Maria de LourdesMorais Fernandes, Ana PaulaDeghaide, Neifi Hassan SalumPaula, Jayter Silva deCastelli, Erick C. [UNESP]Mendes-Junior, Celso TeixeiraDonadi, Eduardo Antonio2018-11-26T17:55:28Z2018-11-26T17:55:28Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5application/pdfhttp://dx.doi.org/10.1155/2018/3830104Journal Of Ophthalmology. London: Hindawi Ltd, 5 p., 2018.2090-004Xhttp://hdl.handle.net/11449/16465310.1155/2018/3830104WOS:000444893700001WOS000444893700001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Ophthalmologyinfo:eu-repo/semantics/openAccess2024-09-03T13:17:50Zoai:repositorio.unesp.br:11449/164653Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:17:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
title |
HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
spellingShingle |
HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS Biberg-Salum, Tania Gisela |
title_short |
HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
title_full |
HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
title_fullStr |
HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
title_full_unstemmed |
HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
title_sort |
HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS |
author |
Biberg-Salum, Tania Gisela |
author_facet |
Biberg-Salum, Tania Gisela Veronese Rodrigues, Maria de Lourdes Morais Fernandes, Ana Paula Deghaide, Neifi Hassan Salum Paula, Jayter Silva de Castelli, Erick C. [UNESP] Mendes-Junior, Celso Teixeira Donadi, Eduardo Antonio |
author_role |
author |
author2 |
Veronese Rodrigues, Maria de Lourdes Morais Fernandes, Ana Paula Deghaide, Neifi Hassan Salum Paula, Jayter Silva de Castelli, Erick C. [UNESP] Mendes-Junior, Celso Teixeira Donadi, Eduardo Antonio |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Biberg-Salum, Tania Gisela Veronese Rodrigues, Maria de Lourdes Morais Fernandes, Ana Paula Deghaide, Neifi Hassan Salum Paula, Jayter Silva de Castelli, Erick C. [UNESP] Mendes-Junior, Celso Teixeira Donadi, Eduardo Antonio |
description |
Purpose. Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and HLA-C alleles have been associated with AIDS disease outcome, we typed HLA-C locus in patients with AIDS exhibiting or not CR. Methods. Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). HLA-C typing was performed using commercial kits. Results. The H LA-C*07 allele group was underrepresented in AIDS patients with CR (P = 0.005) when compared to controls or when compared to AIDS patients without CR (P = 0.006). The IILA-C*05 allele group was overrepresented in Group II in comparison to Group III (P = 0.017). The frequency of the HLA-C* 16 allele group was increased in Group III in comparison to Group II (P = 0.004). Conclusion. The HLA-C*07 allele group conferred protection against the development of CR in Brazilian AIDS patients, whereas the HLA-C*05 and HLA-C*16 allele groups were associated with AIDS susceptibility or protection, respectively. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T17:55:28Z 2018-11-26T17:55:28Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2018/3830104 Journal Of Ophthalmology. London: Hindawi Ltd, 5 p., 2018. 2090-004X http://hdl.handle.net/11449/164653 10.1155/2018/3830104 WOS:000444893700001 WOS000444893700001.pdf |
url |
http://dx.doi.org/10.1155/2018/3830104 http://hdl.handle.net/11449/164653 |
identifier_str_mv |
Journal Of Ophthalmology. London: Hindawi Ltd, 5 p., 2018. 2090-004X 10.1155/2018/3830104 WOS:000444893700001 WOS000444893700001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Ophthalmology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Ltd |
publisher.none.fl_str_mv |
Hindawi Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021398031106048 |