Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis

Detalhes bibliográficos
Autor(a) principal: Scomparin, Rodrigo Corsato [UNESP]
Data de Publicação: 2021
Outros Autores: Lourencao, Pedro Luiz Toledo De Arruda [UNESP], Comes, Giovana Tuccile [UNESP], De Oliveira Junior, Wilson Elias [UNESP], Angelini, Marcos Curcio [UNESP], de Amorim, Paulo Cezar Haddad [UNESP], Terra, Simone Antunes [UNESP], Rodrigues, Maria Aparecida Marchesan [UNESP], Ortolan, Erika Veruska Paiva [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s00431-020-03838-7
http://hdl.handle.net/11449/206665
Resumo: Little attention has been given to the efficiency and validity of performing routine endoscopic biopsies in normal areas in children. This study aimed to investigate the need to perform routine biopsies in upper gastrointestinal endoscopy (UDE) and colonoscopy in normal areas by comparing macroscopy and histology. It was a 10-year retrospective analysis with the inclusion of 761 UDEs and 177 colonoscopies. Considering all segments, UDEs showed false-positive result rates of 73.11% and false-negative result rates of 14.34%. The histological results modified the initial management in 53.95% of patients. Considering all segments, colonoscopies showed false-positive result rates of 63.64% and false-negative result rates of 30.97%. The histological results modified the initial management in 34.45% of patients. Conclusion: If biopsies were obtained only in abnormal areas, the diagnosis would be lost in 53.95% of the patients in upper endoscopies and 85.7% of the colonoscopies, which justifies routine maintenance of biopsies in macroscopically normal areas in children.What is Known:• Little attention has been given to the efficiency and validity of endoscopic biopsies of normal areas during pediatric exams.• Only a few pediatric studies have correlated macroscopic and histological findings from endoscopic biopsies, and low sensitivity and specificity, as well as poor agreement, were reported.What is New:• Our study confirms the evidence that routine biopsies from macroscopically normal areas during upper and lower digestive endoscopies can lead to histopathological diagnoses and different medical management.• This is the first research on this topic in a Latin population, from a developing country, reassuring the results obtained in previous papers from other countries.
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spelling Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysisBiopsiesColonoscopyHistopathological analysisPediatricUpper digestive endoscopyLittle attention has been given to the efficiency and validity of performing routine endoscopic biopsies in normal areas in children. This study aimed to investigate the need to perform routine biopsies in upper gastrointestinal endoscopy (UDE) and colonoscopy in normal areas by comparing macroscopy and histology. It was a 10-year retrospective analysis with the inclusion of 761 UDEs and 177 colonoscopies. Considering all segments, UDEs showed false-positive result rates of 73.11% and false-negative result rates of 14.34%. The histological results modified the initial management in 53.95% of patients. Considering all segments, colonoscopies showed false-positive result rates of 63.64% and false-negative result rates of 30.97%. The histological results modified the initial management in 34.45% of patients. Conclusion: If biopsies were obtained only in abnormal areas, the diagnosis would be lost in 53.95% of the patients in upper endoscopies and 85.7% of the colonoscopies, which justifies routine maintenance of biopsies in macroscopically normal areas in children.What is Known:• Little attention has been given to the efficiency and validity of endoscopic biopsies of normal areas during pediatric exams.• Only a few pediatric studies have correlated macroscopic and histological findings from endoscopic biopsies, and low sensitivity and specificity, as well as poor agreement, were reported.What is New:• Our study confirms the evidence that routine biopsies from macroscopically normal areas during upper and lower digestive endoscopies can lead to histopathological diagnoses and different medical management.• This is the first research on this topic in a Latin population, from a developing country, reassuring the results obtained in previous papers from other countries.Endoscopy Unit Botucatu Medical School UNESPFaculdade de Medicina de Botucatu, Distrito de Rubia Jr s/nPediatric Surgery and Endoscopy Unit Botucatu Medical School UNESPPathology Department Botucatu Medical School Hospital UNESPEndoscopy Unit Botucatu Medical School UNESPFaculdade de Medicina de Botucatu, Distrito de Rubia Jr s/nPediatric Surgery and Endoscopy Unit Botucatu Medical School UNESPPathology Department Botucatu Medical School Hospital UNESPUniversidade Estadual Paulista (Unesp)Scomparin, Rodrigo Corsato [UNESP]Lourencao, Pedro Luiz Toledo De Arruda [UNESP]Comes, Giovana Tuccile [UNESP]De Oliveira Junior, Wilson Elias [UNESP]Angelini, Marcos Curcio [UNESP]de Amorim, Paulo Cezar Haddad [UNESP]Terra, Simone Antunes [UNESP]Rodrigues, Maria Aparecida Marchesan [UNESP]Ortolan, Erika Veruska Paiva [UNESP]2021-06-25T10:36:05Z2021-06-25T10:36:05Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1089-1098http://dx.doi.org/10.1007/s00431-020-03838-7European Journal of Pediatrics, v. 180, n. 4, p. 1089-1098, 2021.1432-10760340-6199http://hdl.handle.net/11449/20666510.1007/s00431-020-03838-72-s2.0-85092543006Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Pediatricsinfo:eu-repo/semantics/openAccess2024-09-03T13:47:04Zoai:repositorio.unesp.br:11449/206665Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:47:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis
title Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis
spellingShingle Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis
Scomparin, Rodrigo Corsato [UNESP]
Biopsies
Colonoscopy
Histopathological analysis
Pediatric
Upper digestive endoscopy
title_short Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis
title_full Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis
title_fullStr Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis
title_full_unstemmed Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis
title_sort Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis
author Scomparin, Rodrigo Corsato [UNESP]
author_facet Scomparin, Rodrigo Corsato [UNESP]
Lourencao, Pedro Luiz Toledo De Arruda [UNESP]
Comes, Giovana Tuccile [UNESP]
De Oliveira Junior, Wilson Elias [UNESP]
Angelini, Marcos Curcio [UNESP]
de Amorim, Paulo Cezar Haddad [UNESP]
Terra, Simone Antunes [UNESP]
Rodrigues, Maria Aparecida Marchesan [UNESP]
Ortolan, Erika Veruska Paiva [UNESP]
author_role author
author2 Lourencao, Pedro Luiz Toledo De Arruda [UNESP]
Comes, Giovana Tuccile [UNESP]
De Oliveira Junior, Wilson Elias [UNESP]
Angelini, Marcos Curcio [UNESP]
de Amorim, Paulo Cezar Haddad [UNESP]
Terra, Simone Antunes [UNESP]
Rodrigues, Maria Aparecida Marchesan [UNESP]
Ortolan, Erika Veruska Paiva [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Scomparin, Rodrigo Corsato [UNESP]
Lourencao, Pedro Luiz Toledo De Arruda [UNESP]
Comes, Giovana Tuccile [UNESP]
De Oliveira Junior, Wilson Elias [UNESP]
Angelini, Marcos Curcio [UNESP]
de Amorim, Paulo Cezar Haddad [UNESP]
Terra, Simone Antunes [UNESP]
Rodrigues, Maria Aparecida Marchesan [UNESP]
Ortolan, Erika Veruska Paiva [UNESP]
dc.subject.por.fl_str_mv Biopsies
Colonoscopy
Histopathological analysis
Pediatric
Upper digestive endoscopy
topic Biopsies
Colonoscopy
Histopathological analysis
Pediatric
Upper digestive endoscopy
description Little attention has been given to the efficiency and validity of performing routine endoscopic biopsies in normal areas in children. This study aimed to investigate the need to perform routine biopsies in upper gastrointestinal endoscopy (UDE) and colonoscopy in normal areas by comparing macroscopy and histology. It was a 10-year retrospective analysis with the inclusion of 761 UDEs and 177 colonoscopies. Considering all segments, UDEs showed false-positive result rates of 73.11% and false-negative result rates of 14.34%. The histological results modified the initial management in 53.95% of patients. Considering all segments, colonoscopies showed false-positive result rates of 63.64% and false-negative result rates of 30.97%. The histological results modified the initial management in 34.45% of patients. Conclusion: If biopsies were obtained only in abnormal areas, the diagnosis would be lost in 53.95% of the patients in upper endoscopies and 85.7% of the colonoscopies, which justifies routine maintenance of biopsies in macroscopically normal areas in children.What is Known:• Little attention has been given to the efficiency and validity of endoscopic biopsies of normal areas during pediatric exams.• Only a few pediatric studies have correlated macroscopic and histological findings from endoscopic biopsies, and low sensitivity and specificity, as well as poor agreement, were reported.What is New:• Our study confirms the evidence that routine biopsies from macroscopically normal areas during upper and lower digestive endoscopies can lead to histopathological diagnoses and different medical management.• This is the first research on this topic in a Latin population, from a developing country, reassuring the results obtained in previous papers from other countries.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:36:05Z
2021-06-25T10:36:05Z
2021-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s00431-020-03838-7
European Journal of Pediatrics, v. 180, n. 4, p. 1089-1098, 2021.
1432-1076
0340-6199
http://hdl.handle.net/11449/206665
10.1007/s00431-020-03838-7
2-s2.0-85092543006
url http://dx.doi.org/10.1007/s00431-020-03838-7
http://hdl.handle.net/11449/206665
identifier_str_mv European Journal of Pediatrics, v. 180, n. 4, p. 1089-1098, 2021.
1432-1076
0340-6199
10.1007/s00431-020-03838-7
2-s2.0-85092543006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv European Journal of Pediatrics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1089-1098
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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