Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00431-020-03838-7 http://hdl.handle.net/11449/206665 |
Resumo: | Little attention has been given to the efficiency and validity of performing routine endoscopic biopsies in normal areas in children. This study aimed to investigate the need to perform routine biopsies in upper gastrointestinal endoscopy (UDE) and colonoscopy in normal areas by comparing macroscopy and histology. It was a 10-year retrospective analysis with the inclusion of 761 UDEs and 177 colonoscopies. Considering all segments, UDEs showed false-positive result rates of 73.11% and false-negative result rates of 14.34%. The histological results modified the initial management in 53.95% of patients. Considering all segments, colonoscopies showed false-positive result rates of 63.64% and false-negative result rates of 30.97%. The histological results modified the initial management in 34.45% of patients. Conclusion: If biopsies were obtained only in abnormal areas, the diagnosis would be lost in 53.95% of the patients in upper endoscopies and 85.7% of the colonoscopies, which justifies routine maintenance of biopsies in macroscopically normal areas in children.What is Known:• Little attention has been given to the efficiency and validity of endoscopic biopsies of normal areas during pediatric exams.• Only a few pediatric studies have correlated macroscopic and histological findings from endoscopic biopsies, and low sensitivity and specificity, as well as poor agreement, were reported.What is New:• Our study confirms the evidence that routine biopsies from macroscopically normal areas during upper and lower digestive endoscopies can lead to histopathological diagnoses and different medical management.• This is the first research on this topic in a Latin population, from a developing country, reassuring the results obtained in previous papers from other countries. |
id |
UNSP_e9ac55102ef3d208c227cc1c37898922 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/206665 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysisBiopsiesColonoscopyHistopathological analysisPediatricUpper digestive endoscopyLittle attention has been given to the efficiency and validity of performing routine endoscopic biopsies in normal areas in children. This study aimed to investigate the need to perform routine biopsies in upper gastrointestinal endoscopy (UDE) and colonoscopy in normal areas by comparing macroscopy and histology. It was a 10-year retrospective analysis with the inclusion of 761 UDEs and 177 colonoscopies. Considering all segments, UDEs showed false-positive result rates of 73.11% and false-negative result rates of 14.34%. The histological results modified the initial management in 53.95% of patients. Considering all segments, colonoscopies showed false-positive result rates of 63.64% and false-negative result rates of 30.97%. The histological results modified the initial management in 34.45% of patients. Conclusion: If biopsies were obtained only in abnormal areas, the diagnosis would be lost in 53.95% of the patients in upper endoscopies and 85.7% of the colonoscopies, which justifies routine maintenance of biopsies in macroscopically normal areas in children.What is Known:• Little attention has been given to the efficiency and validity of endoscopic biopsies of normal areas during pediatric exams.• Only a few pediatric studies have correlated macroscopic and histological findings from endoscopic biopsies, and low sensitivity and specificity, as well as poor agreement, were reported.What is New:• Our study confirms the evidence that routine biopsies from macroscopically normal areas during upper and lower digestive endoscopies can lead to histopathological diagnoses and different medical management.• This is the first research on this topic in a Latin population, from a developing country, reassuring the results obtained in previous papers from other countries.Endoscopy Unit Botucatu Medical School UNESPFaculdade de Medicina de Botucatu, Distrito de Rubia Jr s/nPediatric Surgery and Endoscopy Unit Botucatu Medical School UNESPPathology Department Botucatu Medical School Hospital UNESPEndoscopy Unit Botucatu Medical School UNESPFaculdade de Medicina de Botucatu, Distrito de Rubia Jr s/nPediatric Surgery and Endoscopy Unit Botucatu Medical School UNESPPathology Department Botucatu Medical School Hospital UNESPUniversidade Estadual Paulista (Unesp)Scomparin, Rodrigo Corsato [UNESP]Lourencao, Pedro Luiz Toledo De Arruda [UNESP]Comes, Giovana Tuccile [UNESP]De Oliveira Junior, Wilson Elias [UNESP]Angelini, Marcos Curcio [UNESP]de Amorim, Paulo Cezar Haddad [UNESP]Terra, Simone Antunes [UNESP]Rodrigues, Maria Aparecida Marchesan [UNESP]Ortolan, Erika Veruska Paiva [UNESP]2021-06-25T10:36:05Z2021-06-25T10:36:05Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1089-1098http://dx.doi.org/10.1007/s00431-020-03838-7European Journal of Pediatrics, v. 180, n. 4, p. 1089-1098, 2021.1432-10760340-6199http://hdl.handle.net/11449/20666510.1007/s00431-020-03838-72-s2.0-85092543006Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Pediatricsinfo:eu-repo/semantics/openAccess2024-09-03T13:47:04Zoai:repositorio.unesp.br:11449/206665Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:47:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis |
title |
Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis |
spellingShingle |
Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis Scomparin, Rodrigo Corsato [UNESP] Biopsies Colonoscopy Histopathological analysis Pediatric Upper digestive endoscopy |
title_short |
Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis |
title_full |
Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis |
title_fullStr |
Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis |
title_full_unstemmed |
Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis |
title_sort |
Are biopsies always necessary in upper and lower gastrointestinal endoscopy in children? A retrospective 10-year analysis |
author |
Scomparin, Rodrigo Corsato [UNESP] |
author_facet |
Scomparin, Rodrigo Corsato [UNESP] Lourencao, Pedro Luiz Toledo De Arruda [UNESP] Comes, Giovana Tuccile [UNESP] De Oliveira Junior, Wilson Elias [UNESP] Angelini, Marcos Curcio [UNESP] de Amorim, Paulo Cezar Haddad [UNESP] Terra, Simone Antunes [UNESP] Rodrigues, Maria Aparecida Marchesan [UNESP] Ortolan, Erika Veruska Paiva [UNESP] |
author_role |
author |
author2 |
Lourencao, Pedro Luiz Toledo De Arruda [UNESP] Comes, Giovana Tuccile [UNESP] De Oliveira Junior, Wilson Elias [UNESP] Angelini, Marcos Curcio [UNESP] de Amorim, Paulo Cezar Haddad [UNESP] Terra, Simone Antunes [UNESP] Rodrigues, Maria Aparecida Marchesan [UNESP] Ortolan, Erika Veruska Paiva [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Scomparin, Rodrigo Corsato [UNESP] Lourencao, Pedro Luiz Toledo De Arruda [UNESP] Comes, Giovana Tuccile [UNESP] De Oliveira Junior, Wilson Elias [UNESP] Angelini, Marcos Curcio [UNESP] de Amorim, Paulo Cezar Haddad [UNESP] Terra, Simone Antunes [UNESP] Rodrigues, Maria Aparecida Marchesan [UNESP] Ortolan, Erika Veruska Paiva [UNESP] |
dc.subject.por.fl_str_mv |
Biopsies Colonoscopy Histopathological analysis Pediatric Upper digestive endoscopy |
topic |
Biopsies Colonoscopy Histopathological analysis Pediatric Upper digestive endoscopy |
description |
Little attention has been given to the efficiency and validity of performing routine endoscopic biopsies in normal areas in children. This study aimed to investigate the need to perform routine biopsies in upper gastrointestinal endoscopy (UDE) and colonoscopy in normal areas by comparing macroscopy and histology. It was a 10-year retrospective analysis with the inclusion of 761 UDEs and 177 colonoscopies. Considering all segments, UDEs showed false-positive result rates of 73.11% and false-negative result rates of 14.34%. The histological results modified the initial management in 53.95% of patients. Considering all segments, colonoscopies showed false-positive result rates of 63.64% and false-negative result rates of 30.97%. The histological results modified the initial management in 34.45% of patients. Conclusion: If biopsies were obtained only in abnormal areas, the diagnosis would be lost in 53.95% of the patients in upper endoscopies and 85.7% of the colonoscopies, which justifies routine maintenance of biopsies in macroscopically normal areas in children.What is Known:• Little attention has been given to the efficiency and validity of endoscopic biopsies of normal areas during pediatric exams.• Only a few pediatric studies have correlated macroscopic and histological findings from endoscopic biopsies, and low sensitivity and specificity, as well as poor agreement, were reported.What is New:• Our study confirms the evidence that routine biopsies from macroscopically normal areas during upper and lower digestive endoscopies can lead to histopathological diagnoses and different medical management.• This is the first research on this topic in a Latin population, from a developing country, reassuring the results obtained in previous papers from other countries. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:36:05Z 2021-06-25T10:36:05Z 2021-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00431-020-03838-7 European Journal of Pediatrics, v. 180, n. 4, p. 1089-1098, 2021. 1432-1076 0340-6199 http://hdl.handle.net/11449/206665 10.1007/s00431-020-03838-7 2-s2.0-85092543006 |
url |
http://dx.doi.org/10.1007/s00431-020-03838-7 http://hdl.handle.net/11449/206665 |
identifier_str_mv |
European Journal of Pediatrics, v. 180, n. 4, p. 1089-1098, 2021. 1432-1076 0340-6199 10.1007/s00431-020-03838-7 2-s2.0-85092543006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal of Pediatrics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1089-1098 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021420402475008 |