Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jash.2018.06.004 http://hdl.handle.net/11449/177153 |
Resumo: | Hypertension is one of the chronic side effects of dexamethasone (DEX) treatment; however, almost nothing is known about its acute effects. Therefore, the aim of this study was to investigate the possible mechanisms involved in blood pressure control after acute or short-term DEX treatment in adult animals. Eighty Wistar rats were divided into four groups: C1 and C5, for rats treated with saline for 1 or 5 days, respectively; D1 and D5, for rats treated with DEX for 1 or 5 days, respectively (decadron, 1 mg/kg, i.p.). Heart rate was increased in DEX treatment, but arterial pressure and cardiac muscle mass were not altered. Only few and isolated changes on gene expression and protein level of renin-angiotensin system components were observed. Five days of DEX treatment, but not one day, determined an increase in sympathetic component of spectral analysis (+75.93%, P <.05) and a significant reduction of parasympathetic component (–18.02%, P <.05), which contributed to the autonomic imbalance to the heart (LF/HF, +863.69%). The results of this present study demonstrated, for the first time, that short-term exposure to DEX treatment impairs the autonomic balance to the heart before hypertension, which was independent of renin-angiotensin system. |
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Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertensionAutonomic nervous systemblood pressureglucocorticoidsHypertension is one of the chronic side effects of dexamethasone (DEX) treatment; however, almost nothing is known about its acute effects. Therefore, the aim of this study was to investigate the possible mechanisms involved in blood pressure control after acute or short-term DEX treatment in adult animals. Eighty Wistar rats were divided into four groups: C1 and C5, for rats treated with saline for 1 or 5 days, respectively; D1 and D5, for rats treated with DEX for 1 or 5 days, respectively (decadron, 1 mg/kg, i.p.). Heart rate was increased in DEX treatment, but arterial pressure and cardiac muscle mass were not altered. Only few and isolated changes on gene expression and protein level of renin-angiotensin system components were observed. Five days of DEX treatment, but not one day, determined an increase in sympathetic component of spectral analysis (+75.93%, P <.05) and a significant reduction of parasympathetic component (–18.02%, P <.05), which contributed to the autonomic imbalance to the heart (LF/HF, +863.69%). The results of this present study demonstrated, for the first time, that short-term exposure to DEX treatment impairs the autonomic balance to the heart before hypertension, which was independent of renin-angiotensin system.Joint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESPDepartment of Physical Education Science Faculty UNESP – São Paulo State UniversityDepartment of Biological Sciences Bauru School of Dentistry USP – University of São PauloJoint Graduate Program in Physiological Sciences PIPGCF UFSCar/UNESPDepartment of Physical Education Science Faculty UNESP – São Paulo State UniversityUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Duchatsch, Francine [UNESP]Constantino, Paula B. [UNESP]Herrera, Naiara A. [UNESP]Fabrício, Mayara F. [UNESP]Tardelli, Lidieli P. [UNESP]Martuscelli, Aline M. [UNESP]Dionísio, Thiago J.Santos, Carlos F.Amaral, Sandra L. [UNESP]2018-12-11T17:24:14Z2018-12-11T17:24:14Z2018-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article605-613application/pdfhttp://dx.doi.org/10.1016/j.jash.2018.06.004Journal of the American Society of Hypertension, v. 12, n. 8, p. 605-613, 2018.1878-74361933-1711http://hdl.handle.net/11449/17715310.1016/j.jash.2018.06.0042-s2.0-850488692182-s2.0-85048869218.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the American Society of Hypertension1,104info:eu-repo/semantics/openAccess2024-04-23T15:23:39Zoai:repositorio.unesp.br:11449/177153Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:46:52.327525Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension |
title |
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension |
spellingShingle |
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension Duchatsch, Francine [UNESP] Autonomic nervous system blood pressure glucocorticoids |
title_short |
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension |
title_full |
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension |
title_fullStr |
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension |
title_full_unstemmed |
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension |
title_sort |
Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension |
author |
Duchatsch, Francine [UNESP] |
author_facet |
Duchatsch, Francine [UNESP] Constantino, Paula B. [UNESP] Herrera, Naiara A. [UNESP] Fabrício, Mayara F. [UNESP] Tardelli, Lidieli P. [UNESP] Martuscelli, Aline M. [UNESP] Dionísio, Thiago J. Santos, Carlos F. Amaral, Sandra L. [UNESP] |
author_role |
author |
author2 |
Constantino, Paula B. [UNESP] Herrera, Naiara A. [UNESP] Fabrício, Mayara F. [UNESP] Tardelli, Lidieli P. [UNESP] Martuscelli, Aline M. [UNESP] Dionísio, Thiago J. Santos, Carlos F. Amaral, Sandra L. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Duchatsch, Francine [UNESP] Constantino, Paula B. [UNESP] Herrera, Naiara A. [UNESP] Fabrício, Mayara F. [UNESP] Tardelli, Lidieli P. [UNESP] Martuscelli, Aline M. [UNESP] Dionísio, Thiago J. Santos, Carlos F. Amaral, Sandra L. [UNESP] |
dc.subject.por.fl_str_mv |
Autonomic nervous system blood pressure glucocorticoids |
topic |
Autonomic nervous system blood pressure glucocorticoids |
description |
Hypertension is one of the chronic side effects of dexamethasone (DEX) treatment; however, almost nothing is known about its acute effects. Therefore, the aim of this study was to investigate the possible mechanisms involved in blood pressure control after acute or short-term DEX treatment in adult animals. Eighty Wistar rats were divided into four groups: C1 and C5, for rats treated with saline for 1 or 5 days, respectively; D1 and D5, for rats treated with DEX for 1 or 5 days, respectively (decadron, 1 mg/kg, i.p.). Heart rate was increased in DEX treatment, but arterial pressure and cardiac muscle mass were not altered. Only few and isolated changes on gene expression and protein level of renin-angiotensin system components were observed. Five days of DEX treatment, but not one day, determined an increase in sympathetic component of spectral analysis (+75.93%, P <.05) and a significant reduction of parasympathetic component (–18.02%, P <.05), which contributed to the autonomic imbalance to the heart (LF/HF, +863.69%). The results of this present study demonstrated, for the first time, that short-term exposure to DEX treatment impairs the autonomic balance to the heart before hypertension, which was independent of renin-angiotensin system. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:24:14Z 2018-12-11T17:24:14Z 2018-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jash.2018.06.004 Journal of the American Society of Hypertension, v. 12, n. 8, p. 605-613, 2018. 1878-7436 1933-1711 http://hdl.handle.net/11449/177153 10.1016/j.jash.2018.06.004 2-s2.0-85048869218 2-s2.0-85048869218.pdf |
url |
http://dx.doi.org/10.1016/j.jash.2018.06.004 http://hdl.handle.net/11449/177153 |
identifier_str_mv |
Journal of the American Society of Hypertension, v. 12, n. 8, p. 605-613, 2018. 1878-7436 1933-1711 10.1016/j.jash.2018.06.004 2-s2.0-85048869218 2-s2.0-85048869218.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of the American Society of Hypertension 1,104 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
605-613 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129118109171712 |