Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-5150-PVB-5776 http://hdl.handle.net/11449/187133 |
Resumo: | Technological and tissue engineering have enabled available, biologically inert, and low cost materials to be considered as viable alternatives in the surgical treatment of long bone fractures in birds. The aim of this study was to microscopically analyse osteotomized humerus of birds following the insertion of solid laser-sintered polyamide 12 rods in order to detect foreign body reaction and, thus, verify the bioinert property of the material in the bone fracture environment. Polyamide 12 intramedullary rods were inserted into the osteotomized humerus of 10 birds (white Plymouth Rock) and blocked using 2mm diameter cortical screws of varying lengths. The birds were operated at 60 days of age and monitored post-operatively for three months. Animals were euthanized at 150 days old and samples of the operated humerus collected for immunohistochemistry, light and scanning electron microscopy analysis. Results show bone consolidation without rejection of the implant and absence of inflammatory cells. Vascular Endothelial Growth Factor (VEGF) was expressed in the endothelial cells of the blood vessels at the site of the newly formed bone surrounding the implant, indicative of local angiogenesis. There was no bone growth on the surface of the rod; however, the implant did not interfere with the circumjacent bone repair. Thus, the findings of this study corroborate with the literature in characterizing polyamide as a bioinert material and, under the studied conditions, it can be concluded that polyamide 12 intramedullary rod is biocompatible and provides adequate bone consolidation in humeral fractures with no signs of rejection. |
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Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birdsBiocompatibilityBioinertBiomaterialBirdsForeign bodyHumerusIntramedullary rodOsteosynthesisPolyamide 12RejectionWhite Plymouth RockTechnological and tissue engineering have enabled available, biologically inert, and low cost materials to be considered as viable alternatives in the surgical treatment of long bone fractures in birds. The aim of this study was to microscopically analyse osteotomized humerus of birds following the insertion of solid laser-sintered polyamide 12 rods in order to detect foreign body reaction and, thus, verify the bioinert property of the material in the bone fracture environment. Polyamide 12 intramedullary rods were inserted into the osteotomized humerus of 10 birds (white Plymouth Rock) and blocked using 2mm diameter cortical screws of varying lengths. The birds were operated at 60 days of age and monitored post-operatively for three months. Animals were euthanized at 150 days old and samples of the operated humerus collected for immunohistochemistry, light and scanning electron microscopy analysis. Results show bone consolidation without rejection of the implant and absence of inflammatory cells. Vascular Endothelial Growth Factor (VEGF) was expressed in the endothelial cells of the blood vessels at the site of the newly formed bone surrounding the implant, indicative of local angiogenesis. There was no bone growth on the surface of the rod; however, the implant did not interfere with the circumjacent bone repair. Thus, the findings of this study corroborate with the literature in characterizing polyamide as a bioinert material and, under the studied conditions, it can be concluded that polyamide 12 intramedullary rod is biocompatible and provides adequate bone consolidation in humeral fractures with no signs of rejection.Universidade de Franca (Unifran), Avenida Dr. Armando Salles de Oliveira 201Instituto Federal do Sul de Minas, Rua Muzambinho Km 35Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista “Julio de Mesquita Filho” (Unesp), Avenida Prof. Paulo Donato CastelaneDepartamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista “Julio de Mesquita Filho” (Unesp), Avenida Prof. Paulo Donato CastelaneUniversidade de Franca (Unifran)Instituto Federal do Sul de MinasUniversidade Estadual Paulista (Unesp)Dias, Romim G.Magalhães, Georgia M.Dias, Luís Gustavo G.G. [UNESP]Rocha, Jessé R.Dias, Fernanda G.G.Facin, Andréia C. [UNESP]Mattos, Ewaldo2019-10-06T15:26:28Z2019-10-06T15:26:28Z2018-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1909-1912application/pdfhttp://dx.doi.org/10.1590/1678-5150-PVB-5776Pesquisa Veterinaria Brasileira, v. 38, n. 10, p. 1909-1912, 2018.1678-51500100-736Xhttp://hdl.handle.net/11449/18713310.1590/1678-5150-PVB-5776S0100-736X20180010019092-s2.0-85057725460S0100-736X2018001001909.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2023-10-07T06:07:37Zoai:repositorio.unesp.br:11449/187133Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:16:38.825705Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds |
title |
Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds |
spellingShingle |
Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds Dias, Romim G. Biocompatibility Bioinert Biomaterial Birds Foreign body Humerus Intramedullary rod Osteosynthesis Polyamide 12 Rejection White Plymouth Rock |
title_short |
Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds |
title_full |
Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds |
title_fullStr |
Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds |
title_full_unstemmed |
Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds |
title_sort |
Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds |
author |
Dias, Romim G. |
author_facet |
Dias, Romim G. Magalhães, Georgia M. Dias, Luís Gustavo G.G. [UNESP] Rocha, Jessé R. Dias, Fernanda G.G. Facin, Andréia C. [UNESP] Mattos, Ewaldo |
author_role |
author |
author2 |
Magalhães, Georgia M. Dias, Luís Gustavo G.G. [UNESP] Rocha, Jessé R. Dias, Fernanda G.G. Facin, Andréia C. [UNESP] Mattos, Ewaldo |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de Franca (Unifran) Instituto Federal do Sul de Minas Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Dias, Romim G. Magalhães, Georgia M. Dias, Luís Gustavo G.G. [UNESP] Rocha, Jessé R. Dias, Fernanda G.G. Facin, Andréia C. [UNESP] Mattos, Ewaldo |
dc.subject.por.fl_str_mv |
Biocompatibility Bioinert Biomaterial Birds Foreign body Humerus Intramedullary rod Osteosynthesis Polyamide 12 Rejection White Plymouth Rock |
topic |
Biocompatibility Bioinert Biomaterial Birds Foreign body Humerus Intramedullary rod Osteosynthesis Polyamide 12 Rejection White Plymouth Rock |
description |
Technological and tissue engineering have enabled available, biologically inert, and low cost materials to be considered as viable alternatives in the surgical treatment of long bone fractures in birds. The aim of this study was to microscopically analyse osteotomized humerus of birds following the insertion of solid laser-sintered polyamide 12 rods in order to detect foreign body reaction and, thus, verify the bioinert property of the material in the bone fracture environment. Polyamide 12 intramedullary rods were inserted into the osteotomized humerus of 10 birds (white Plymouth Rock) and blocked using 2mm diameter cortical screws of varying lengths. The birds were operated at 60 days of age and monitored post-operatively for three months. Animals were euthanized at 150 days old and samples of the operated humerus collected for immunohistochemistry, light and scanning electron microscopy analysis. Results show bone consolidation without rejection of the implant and absence of inflammatory cells. Vascular Endothelial Growth Factor (VEGF) was expressed in the endothelial cells of the blood vessels at the site of the newly formed bone surrounding the implant, indicative of local angiogenesis. There was no bone growth on the surface of the rod; however, the implant did not interfere with the circumjacent bone repair. Thus, the findings of this study corroborate with the literature in characterizing polyamide as a bioinert material and, under the studied conditions, it can be concluded that polyamide 12 intramedullary rod is biocompatible and provides adequate bone consolidation in humeral fractures with no signs of rejection. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 2019-10-06T15:26:28Z 2019-10-06T15:26:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-5150-PVB-5776 Pesquisa Veterinaria Brasileira, v. 38, n. 10, p. 1909-1912, 2018. 1678-5150 0100-736X http://hdl.handle.net/11449/187133 10.1590/1678-5150-PVB-5776 S0100-736X2018001001909 2-s2.0-85057725460 S0100-736X2018001001909.pdf |
url |
http://dx.doi.org/10.1590/1678-5150-PVB-5776 http://hdl.handle.net/11449/187133 |
identifier_str_mv |
Pesquisa Veterinaria Brasileira, v. 38, n. 10, p. 1909-1912, 2018. 1678-5150 0100-736X 10.1590/1678-5150-PVB-5776 S0100-736X2018001001909 2-s2.0-85057725460 S0100-736X2018001001909.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Veterinaria Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1909-1912 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128339223773184 |