Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds

Detalhes bibliográficos
Autor(a) principal: Dias, Romim G.
Data de Publicação: 2018
Outros Autores: Magalhães, Georgia M., Dias, Luís Gustavo G.G. [UNESP], Rocha, Jessé R., Dias, Fernanda G.G., Facin, Andréia C. [UNESP], Mattos, Ewaldo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-5150-PVB-5776
http://hdl.handle.net/11449/187133
Resumo: Technological and tissue engineering have enabled available, biologically inert, and low cost materials to be considered as viable alternatives in the surgical treatment of long bone fractures in birds. The aim of this study was to microscopically analyse osteotomized humerus of birds following the insertion of solid laser-sintered polyamide 12 rods in order to detect foreign body reaction and, thus, verify the bioinert property of the material in the bone fracture environment. Polyamide 12 intramedullary rods were inserted into the osteotomized humerus of 10 birds (white Plymouth Rock) and blocked using 2mm diameter cortical screws of varying lengths. The birds were operated at 60 days of age and monitored post-operatively for three months. Animals were euthanized at 150 days old and samples of the operated humerus collected for immunohistochemistry, light and scanning electron microscopy analysis. Results show bone consolidation without rejection of the implant and absence of inflammatory cells. Vascular Endothelial Growth Factor (VEGF) was expressed in the endothelial cells of the blood vessels at the site of the newly formed bone surrounding the implant, indicative of local angiogenesis. There was no bone growth on the surface of the rod; however, the implant did not interfere with the circumjacent bone repair. Thus, the findings of this study corroborate with the literature in characterizing polyamide as a bioinert material and, under the studied conditions, it can be concluded that polyamide 12 intramedullary rod is biocompatible and provides adequate bone consolidation in humeral fractures with no signs of rejection.
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spelling Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birdsBiocompatibilityBioinertBiomaterialBirdsForeign bodyHumerusIntramedullary rodOsteosynthesisPolyamide 12RejectionWhite Plymouth RockTechnological and tissue engineering have enabled available, biologically inert, and low cost materials to be considered as viable alternatives in the surgical treatment of long bone fractures in birds. The aim of this study was to microscopically analyse osteotomized humerus of birds following the insertion of solid laser-sintered polyamide 12 rods in order to detect foreign body reaction and, thus, verify the bioinert property of the material in the bone fracture environment. Polyamide 12 intramedullary rods were inserted into the osteotomized humerus of 10 birds (white Plymouth Rock) and blocked using 2mm diameter cortical screws of varying lengths. The birds were operated at 60 days of age and monitored post-operatively for three months. Animals were euthanized at 150 days old and samples of the operated humerus collected for immunohistochemistry, light and scanning electron microscopy analysis. Results show bone consolidation without rejection of the implant and absence of inflammatory cells. Vascular Endothelial Growth Factor (VEGF) was expressed in the endothelial cells of the blood vessels at the site of the newly formed bone surrounding the implant, indicative of local angiogenesis. There was no bone growth on the surface of the rod; however, the implant did not interfere with the circumjacent bone repair. Thus, the findings of this study corroborate with the literature in characterizing polyamide as a bioinert material and, under the studied conditions, it can be concluded that polyamide 12 intramedullary rod is biocompatible and provides adequate bone consolidation in humeral fractures with no signs of rejection.Universidade de Franca (Unifran), Avenida Dr. Armando Salles de Oliveira 201Instituto Federal do Sul de Minas, Rua Muzambinho Km 35Departamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista “Julio de Mesquita Filho” (Unesp), Avenida Prof. Paulo Donato CastelaneDepartamento de Clínica e Cirurgia Veterinária Universidade Estadual Paulista “Julio de Mesquita Filho” (Unesp), Avenida Prof. Paulo Donato CastelaneUniversidade de Franca (Unifran)Instituto Federal do Sul de MinasUniversidade Estadual Paulista (Unesp)Dias, Romim G.Magalhães, Georgia M.Dias, Luís Gustavo G.G. [UNESP]Rocha, Jessé R.Dias, Fernanda G.G.Facin, Andréia C. [UNESP]Mattos, Ewaldo2019-10-06T15:26:28Z2019-10-06T15:26:28Z2018-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1909-1912application/pdfhttp://dx.doi.org/10.1590/1678-5150-PVB-5776Pesquisa Veterinaria Brasileira, v. 38, n. 10, p. 1909-1912, 2018.1678-51500100-736Xhttp://hdl.handle.net/11449/18713310.1590/1678-5150-PVB-5776S0100-736X20180010019092-s2.0-85057725460S0100-736X2018001001909.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2023-10-07T06:07:37Zoai:repositorio.unesp.br:11449/187133Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:16:38.825705Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds
title Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds
spellingShingle Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds
Dias, Romim G.
Biocompatibility
Bioinert
Biomaterial
Birds
Foreign body
Humerus
Intramedullary rod
Osteosynthesis
Polyamide 12
Rejection
White Plymouth Rock
title_short Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds
title_full Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds
title_fullStr Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds
title_full_unstemmed Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds
title_sort Biocompatibility of polyamide 12 intramedullary rod after humeral consolidation in white Plymouth Rock birds
author Dias, Romim G.
author_facet Dias, Romim G.
Magalhães, Georgia M.
Dias, Luís Gustavo G.G. [UNESP]
Rocha, Jessé R.
Dias, Fernanda G.G.
Facin, Andréia C. [UNESP]
Mattos, Ewaldo
author_role author
author2 Magalhães, Georgia M.
Dias, Luís Gustavo G.G. [UNESP]
Rocha, Jessé R.
Dias, Fernanda G.G.
Facin, Andréia C. [UNESP]
Mattos, Ewaldo
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Franca (Unifran)
Instituto Federal do Sul de Minas
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Dias, Romim G.
Magalhães, Georgia M.
Dias, Luís Gustavo G.G. [UNESP]
Rocha, Jessé R.
Dias, Fernanda G.G.
Facin, Andréia C. [UNESP]
Mattos, Ewaldo
dc.subject.por.fl_str_mv Biocompatibility
Bioinert
Biomaterial
Birds
Foreign body
Humerus
Intramedullary rod
Osteosynthesis
Polyamide 12
Rejection
White Plymouth Rock
topic Biocompatibility
Bioinert
Biomaterial
Birds
Foreign body
Humerus
Intramedullary rod
Osteosynthesis
Polyamide 12
Rejection
White Plymouth Rock
description Technological and tissue engineering have enabled available, biologically inert, and low cost materials to be considered as viable alternatives in the surgical treatment of long bone fractures in birds. The aim of this study was to microscopically analyse osteotomized humerus of birds following the insertion of solid laser-sintered polyamide 12 rods in order to detect foreign body reaction and, thus, verify the bioinert property of the material in the bone fracture environment. Polyamide 12 intramedullary rods were inserted into the osteotomized humerus of 10 birds (white Plymouth Rock) and blocked using 2mm diameter cortical screws of varying lengths. The birds were operated at 60 days of age and monitored post-operatively for three months. Animals were euthanized at 150 days old and samples of the operated humerus collected for immunohistochemistry, light and scanning electron microscopy analysis. Results show bone consolidation without rejection of the implant and absence of inflammatory cells. Vascular Endothelial Growth Factor (VEGF) was expressed in the endothelial cells of the blood vessels at the site of the newly formed bone surrounding the implant, indicative of local angiogenesis. There was no bone growth on the surface of the rod; however, the implant did not interfere with the circumjacent bone repair. Thus, the findings of this study corroborate with the literature in characterizing polyamide as a bioinert material and, under the studied conditions, it can be concluded that polyamide 12 intramedullary rod is biocompatible and provides adequate bone consolidation in humeral fractures with no signs of rejection.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-01
2019-10-06T15:26:28Z
2019-10-06T15:26:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-5150-PVB-5776
Pesquisa Veterinaria Brasileira, v. 38, n. 10, p. 1909-1912, 2018.
1678-5150
0100-736X
http://hdl.handle.net/11449/187133
10.1590/1678-5150-PVB-5776
S0100-736X2018001001909
2-s2.0-85057725460
S0100-736X2018001001909.pdf
url http://dx.doi.org/10.1590/1678-5150-PVB-5776
http://hdl.handle.net/11449/187133
identifier_str_mv Pesquisa Veterinaria Brasileira, v. 38, n. 10, p. 1909-1912, 2018.
1678-5150
0100-736X
10.1590/1678-5150-PVB-5776
S0100-736X2018001001909
2-s2.0-85057725460
S0100-736X2018001001909.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pesquisa Veterinaria Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1909-1912
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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