Complex segregation analysis of facial melasma in Brazil: evidence for a genetic susceptibility with a dominant pattern of segregation

• Autor(a) principal: Holmo, Nicole França [UNESP]
• Data de Publicação: 2018
• Outros Autores: Ramos, Geovana Brotto, Salomão, Heloisa, Werneck, Renata Iani, Mira, Marcelo Távora, Miot, Luciane Donida Bartoli [UNESP], Miot, Hélio Amante [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1007/s00403-018-1861-5; http://hdl.handle.net/11449/176779
• topic: Genetics; Heredity; Inheritance patterns; Melasma; Pigmentary disorders

Despite high prevalence, the etiopathology of melasma is not fully understood. Nevertheless, many factors have been associated with the disease, including: sun exposure, sex steroids hormones, drugs, stress, and pregnancy. The high occurrence within familiars (40–60%) suggests a genetic predisposition to the disease. This study explored, through complex segregation analysis (CSA), the inheritance model that best fit the family segregation pattern of facial melasma when accounting for the main epidemiological risk factors. We evaluated 686 subjects from 67 families, and 260 (38%) of them had facial melasma. The CSA model, adjusted for age, skin phototype, sex, sun exposure at work, hormonal oral contraceptive, and pregnancy, evidenced a genetic component that was best fitted to a dominant pattern of segregation. Melasma results from an interaction between exposure factors (e.g. pregnancy, hormones, and sun exposure) over genetically predisposed individuals.