The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1117/12.589345 http://hdl.handle.net/11449/67984 |
Resumo: | Diabetes Mellitus is a condition that results in a delay of the wound healing process, that is associated with an insufficient production of collagen, a decrease of the amount of collagen fibrils and deficient blood flow in the wound area. It is suggested that Low Intensity Laser Therapy acts by improving wound healing in normal organisms, accelerating tissue regeneration. The aim of this work was to investigate the biostimulatory effect of the HeNe laser irradiation, at 632.8 nm, on wound healing in 15 male rats suffering from diabetes induced by Streptozotocin, compared to 15 control diabetic animals. Irradiation parameters were: laser power of 15mW, exposition time of 17 s., irradiated area of 0.025 cm 2 and laser energy density of 10 J/cm 2. Full-thickness skin squared samples, with 5 mm of non-injured tissue around the wound, were obtained at 4, 7 and 15 days after wounding procedure (5 treated and 5 control animals each time). The histopathologic analysis performed by haematoxylin-eosin staining. Results suggested that the irradiation of diabetic rats was efficient for wound healing. Treated group presented better quality of the wound tissues by the macroscopic observation than control group and the microscopic analysis demonstrated that treated animals had better histopathologic evaluation than non treated. |
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The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic ratsDiabetesLow Intensity Laser Therapy (LILT)Wound HealingBiodiversityCollagenGlucoseIrradiationMetabolismTissueLaser energyLow intensity laser therapy (LILT)Wound healingLaser beamsDiabetes Mellitus is a condition that results in a delay of the wound healing process, that is associated with an insufficient production of collagen, a decrease of the amount of collagen fibrils and deficient blood flow in the wound area. It is suggested that Low Intensity Laser Therapy acts by improving wound healing in normal organisms, accelerating tissue regeneration. The aim of this work was to investigate the biostimulatory effect of the HeNe laser irradiation, at 632.8 nm, on wound healing in 15 male rats suffering from diabetes induced by Streptozotocin, compared to 15 control diabetic animals. Irradiation parameters were: laser power of 15mW, exposition time of 17 s., irradiated area of 0.025 cm 2 and laser energy density of 10 J/cm 2. Full-thickness skin squared samples, with 5 mm of non-injured tissue around the wound, were obtained at 4, 7 and 15 days after wounding procedure (5 treated and 5 control animals each time). The histopathologic analysis performed by haematoxylin-eosin staining. Results suggested that the irradiation of diabetic rats was efficient for wound healing. Treated group presented better quality of the wound tissues by the macroscopic observation than control group and the microscopic analysis demonstrated that treated animals had better histopathologic evaluation than non treated.Inst. de Pesquisa e Desenvolvimento Universidade do Vale do Paraiba S. José dos Campos, São PauloDepto. Biociencias Diagnostico B.H. Univ. Estadual Paulista - UNESP São José dos Campos, Säo PauloDepto. Biociencias Diagnostico B.H. Univ. Estadual Paulista - UNESP São José dos Campos, Säo PauloS. José dos CamposUniversidade Estadual Paulista (Unesp)Rabelo, S. BicalhoVillaverde, A. BalbinSalgado, M. A. Castilho [UNESP]Da Silva Melo, M.Nicolau, R. AmadeiPacheco, M. T T2014-05-27T11:21:12Z2014-05-27T11:21:12Z2004-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject29-34http://dx.doi.org/10.1117/12.589345Proceedings of SPIE - The International Society for Optical Engineering, v. 5622, n. PART 1, p. 29-34, 2004.0277-786Xhttp://hdl.handle.net/11449/6798410.1117/12.5893452-s2.0-176444027478235700830441386Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProceedings of SPIE - The International Society for Optical Engineeringinfo:eu-repo/semantics/openAccess2021-10-23T21:41:26Zoai:repositorio.unesp.br:11449/67984Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:32:55.445924Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats |
title |
The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats |
spellingShingle |
The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats Rabelo, S. Bicalho Diabetes Low Intensity Laser Therapy (LILT) Wound Healing Biodiversity Collagen Glucose Irradiation Metabolism Tissue Laser energy Low intensity laser therapy (LILT) Wound healing Laser beams |
title_short |
The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats |
title_full |
The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats |
title_fullStr |
The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats |
title_full_unstemmed |
The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats |
title_sort |
The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats |
author |
Rabelo, S. Bicalho |
author_facet |
Rabelo, S. Bicalho Villaverde, A. Balbin Salgado, M. A. Castilho [UNESP] Da Silva Melo, M. Nicolau, R. Amadei Pacheco, M. T T |
author_role |
author |
author2 |
Villaverde, A. Balbin Salgado, M. A. Castilho [UNESP] Da Silva Melo, M. Nicolau, R. Amadei Pacheco, M. T T |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
S. José dos Campos Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Rabelo, S. Bicalho Villaverde, A. Balbin Salgado, M. A. Castilho [UNESP] Da Silva Melo, M. Nicolau, R. Amadei Pacheco, M. T T |
dc.subject.por.fl_str_mv |
Diabetes Low Intensity Laser Therapy (LILT) Wound Healing Biodiversity Collagen Glucose Irradiation Metabolism Tissue Laser energy Low intensity laser therapy (LILT) Wound healing Laser beams |
topic |
Diabetes Low Intensity Laser Therapy (LILT) Wound Healing Biodiversity Collagen Glucose Irradiation Metabolism Tissue Laser energy Low intensity laser therapy (LILT) Wound healing Laser beams |
description |
Diabetes Mellitus is a condition that results in a delay of the wound healing process, that is associated with an insufficient production of collagen, a decrease of the amount of collagen fibrils and deficient blood flow in the wound area. It is suggested that Low Intensity Laser Therapy acts by improving wound healing in normal organisms, accelerating tissue regeneration. The aim of this work was to investigate the biostimulatory effect of the HeNe laser irradiation, at 632.8 nm, on wound healing in 15 male rats suffering from diabetes induced by Streptozotocin, compared to 15 control diabetic animals. Irradiation parameters were: laser power of 15mW, exposition time of 17 s., irradiated area of 0.025 cm 2 and laser energy density of 10 J/cm 2. Full-thickness skin squared samples, with 5 mm of non-injured tissue around the wound, were obtained at 4, 7 and 15 days after wounding procedure (5 treated and 5 control animals each time). The histopathologic analysis performed by haematoxylin-eosin staining. Results suggested that the irradiation of diabetic rats was efficient for wound healing. Treated group presented better quality of the wound tissues by the macroscopic observation than control group and the microscopic analysis demonstrated that treated animals had better histopathologic evaluation than non treated. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-12-01 2014-05-27T11:21:12Z 2014-05-27T11:21:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1117/12.589345 Proceedings of SPIE - The International Society for Optical Engineering, v. 5622, n. PART 1, p. 29-34, 2004. 0277-786X http://hdl.handle.net/11449/67984 10.1117/12.589345 2-s2.0-17644402747 8235700830441386 |
url |
http://dx.doi.org/10.1117/12.589345 http://hdl.handle.net/11449/67984 |
identifier_str_mv |
Proceedings of SPIE - The International Society for Optical Engineering, v. 5622, n. PART 1, p. 29-34, 2004. 0277-786X 10.1117/12.589345 2-s2.0-17644402747 8235700830441386 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Proceedings of SPIE - The International Society for Optical Engineering |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
29-34 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129436076212224 |