The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats

Detalhes bibliográficos
Autor(a) principal: Rabelo, S. Bicalho
Data de Publicação: 2004
Outros Autores: Villaverde, A. Balbin, Salgado, M. A. Castilho [UNESP], Da Silva Melo, M., Nicolau, R. Amadei, Pacheco, M. T T
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1117/12.589345
http://hdl.handle.net/11449/67984
Resumo: Diabetes Mellitus is a condition that results in a delay of the wound healing process, that is associated with an insufficient production of collagen, a decrease of the amount of collagen fibrils and deficient blood flow in the wound area. It is suggested that Low Intensity Laser Therapy acts by improving wound healing in normal organisms, accelerating tissue regeneration. The aim of this work was to investigate the biostimulatory effect of the HeNe laser irradiation, at 632.8 nm, on wound healing in 15 male rats suffering from diabetes induced by Streptozotocin, compared to 15 control diabetic animals. Irradiation parameters were: laser power of 15mW, exposition time of 17 s., irradiated area of 0.025 cm 2 and laser energy density of 10 J/cm 2. Full-thickness skin squared samples, with 5 mm of non-injured tissue around the wound, were obtained at 4, 7 and 15 days after wounding procedure (5 treated and 5 control animals each time). The histopathologic analysis performed by haematoxylin-eosin staining. Results suggested that the irradiation of diabetic rats was efficient for wound healing. Treated group presented better quality of the wound tissues by the macroscopic observation than control group and the microscopic analysis demonstrated that treated animals had better histopathologic evaluation than non treated.
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spelling The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic ratsDiabetesLow Intensity Laser Therapy (LILT)Wound HealingBiodiversityCollagenGlucoseIrradiationMetabolismTissueLaser energyLow intensity laser therapy (LILT)Wound healingLaser beamsDiabetes Mellitus is a condition that results in a delay of the wound healing process, that is associated with an insufficient production of collagen, a decrease of the amount of collagen fibrils and deficient blood flow in the wound area. It is suggested that Low Intensity Laser Therapy acts by improving wound healing in normal organisms, accelerating tissue regeneration. The aim of this work was to investigate the biostimulatory effect of the HeNe laser irradiation, at 632.8 nm, on wound healing in 15 male rats suffering from diabetes induced by Streptozotocin, compared to 15 control diabetic animals. Irradiation parameters were: laser power of 15mW, exposition time of 17 s., irradiated area of 0.025 cm 2 and laser energy density of 10 J/cm 2. Full-thickness skin squared samples, with 5 mm of non-injured tissue around the wound, were obtained at 4, 7 and 15 days after wounding procedure (5 treated and 5 control animals each time). The histopathologic analysis performed by haematoxylin-eosin staining. Results suggested that the irradiation of diabetic rats was efficient for wound healing. Treated group presented better quality of the wound tissues by the macroscopic observation than control group and the microscopic analysis demonstrated that treated animals had better histopathologic evaluation than non treated.Inst. de Pesquisa e Desenvolvimento Universidade do Vale do Paraiba S. José dos Campos, São PauloDepto. Biociencias Diagnostico B.H. Univ. Estadual Paulista - UNESP São José dos Campos, Säo PauloDepto. Biociencias Diagnostico B.H. Univ. Estadual Paulista - UNESP São José dos Campos, Säo PauloS. José dos CamposUniversidade Estadual Paulista (Unesp)Rabelo, S. BicalhoVillaverde, A. BalbinSalgado, M. A. Castilho [UNESP]Da Silva Melo, M.Nicolau, R. AmadeiPacheco, M. T T2014-05-27T11:21:12Z2014-05-27T11:21:12Z2004-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject29-34http://dx.doi.org/10.1117/12.589345Proceedings of SPIE - The International Society for Optical Engineering, v. 5622, n. PART 1, p. 29-34, 2004.0277-786Xhttp://hdl.handle.net/11449/6798410.1117/12.5893452-s2.0-176444027478235700830441386Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProceedings of SPIE - The International Society for Optical Engineeringinfo:eu-repo/semantics/openAccess2021-10-23T21:41:26Zoai:repositorio.unesp.br:11449/67984Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:32:55.445924Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats
title The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats
spellingShingle The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats
Rabelo, S. Bicalho
Diabetes
Low Intensity Laser Therapy (LILT)
Wound Healing
Biodiversity
Collagen
Glucose
Irradiation
Metabolism
Tissue
Laser energy
Low intensity laser therapy (LILT)
Wound healing
Laser beams
title_short The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats
title_full The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats
title_fullStr The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats
title_full_unstemmed The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats
title_sort The effect of low intensity laser therapy on wound healing in Streptozotocin-induced diabetic rats
author Rabelo, S. Bicalho
author_facet Rabelo, S. Bicalho
Villaverde, A. Balbin
Salgado, M. A. Castilho [UNESP]
Da Silva Melo, M.
Nicolau, R. Amadei
Pacheco, M. T T
author_role author
author2 Villaverde, A. Balbin
Salgado, M. A. Castilho [UNESP]
Da Silva Melo, M.
Nicolau, R. Amadei
Pacheco, M. T T
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv S. José dos Campos
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Rabelo, S. Bicalho
Villaverde, A. Balbin
Salgado, M. A. Castilho [UNESP]
Da Silva Melo, M.
Nicolau, R. Amadei
Pacheco, M. T T
dc.subject.por.fl_str_mv Diabetes
Low Intensity Laser Therapy (LILT)
Wound Healing
Biodiversity
Collagen
Glucose
Irradiation
Metabolism
Tissue
Laser energy
Low intensity laser therapy (LILT)
Wound healing
Laser beams
topic Diabetes
Low Intensity Laser Therapy (LILT)
Wound Healing
Biodiversity
Collagen
Glucose
Irradiation
Metabolism
Tissue
Laser energy
Low intensity laser therapy (LILT)
Wound healing
Laser beams
description Diabetes Mellitus is a condition that results in a delay of the wound healing process, that is associated with an insufficient production of collagen, a decrease of the amount of collagen fibrils and deficient blood flow in the wound area. It is suggested that Low Intensity Laser Therapy acts by improving wound healing in normal organisms, accelerating tissue regeneration. The aim of this work was to investigate the biostimulatory effect of the HeNe laser irradiation, at 632.8 nm, on wound healing in 15 male rats suffering from diabetes induced by Streptozotocin, compared to 15 control diabetic animals. Irradiation parameters were: laser power of 15mW, exposition time of 17 s., irradiated area of 0.025 cm 2 and laser energy density of 10 J/cm 2. Full-thickness skin squared samples, with 5 mm of non-injured tissue around the wound, were obtained at 4, 7 and 15 days after wounding procedure (5 treated and 5 control animals each time). The histopathologic analysis performed by haematoxylin-eosin staining. Results suggested that the irradiation of diabetic rats was efficient for wound healing. Treated group presented better quality of the wound tissues by the macroscopic observation than control group and the microscopic analysis demonstrated that treated animals had better histopathologic evaluation than non treated.
publishDate 2004
dc.date.none.fl_str_mv 2004-12-01
2014-05-27T11:21:12Z
2014-05-27T11:21:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1117/12.589345
Proceedings of SPIE - The International Society for Optical Engineering, v. 5622, n. PART 1, p. 29-34, 2004.
0277-786X
http://hdl.handle.net/11449/67984
10.1117/12.589345
2-s2.0-17644402747
8235700830441386
url http://dx.doi.org/10.1117/12.589345
http://hdl.handle.net/11449/67984
identifier_str_mv Proceedings of SPIE - The International Society for Optical Engineering, v. 5622, n. PART 1, p. 29-34, 2004.
0277-786X
10.1117/12.589345
2-s2.0-17644402747
8235700830441386
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Proceedings of SPIE - The International Society for Optical Engineering
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 29-34
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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