The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2016/4257498 http://hdl.handle.net/11449/176898 |
Resumo: | Arsenic trioxide (As2O3) has shown effectiveness in treatment of leukemia but is also associated with reproductive toxicity. Since remediation with N-acetylcysteine (NAC) may mitigate the adverse effects caused by exposure, we assessed the effects of As2O3 and its potential reversibility after exposure cessation or coadministration of NAC. Animals received 0.3 or 3.0 mg/Kg/day of As2O3 subcutaneously and 40 mM of NAC in tap water. As2O3 treatment impaired spermatogenesis and sperm motility and decreased seminal vesicle weight and testosterone serum levels; after suspension of treatment, these parameters remained altered. When NAC was administered, animals showed improvement in sperm parameters and seminal vesicle weight. In vitro epididymal contractility was increased in As2O3-treated animals. We concluded that As2O3 is toxic to the male mouse genital system by compromising sperm quality and quantity; these effects persisted even after suspension of the treatment. However, the coadministration of NAC ameliorates the harmful effects of the drug on the male genital system. |
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The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital systemArsenic trioxide (As2O3) has shown effectiveness in treatment of leukemia but is also associated with reproductive toxicity. Since remediation with N-acetylcysteine (NAC) may mitigate the adverse effects caused by exposure, we assessed the effects of As2O3 and its potential reversibility after exposure cessation or coadministration of NAC. Animals received 0.3 or 3.0 mg/Kg/day of As2O3 subcutaneously and 40 mM of NAC in tap water. As2O3 treatment impaired spermatogenesis and sperm motility and decreased seminal vesicle weight and testosterone serum levels; after suspension of treatment, these parameters remained altered. When NAC was administered, animals showed improvement in sperm parameters and seminal vesicle weight. In vitro epididymal contractility was increased in As2O3-treated animals. We concluded that As2O3 is toxic to the male mouse genital system by compromising sperm quality and quantity; these effects persisted even after suspension of the treatment. However, the coadministration of NAC ameliorates the harmful effects of the drug on the male genital system.Department of Morphology Institute of Biosciences Universidade Estadual Paulista (UNESP)Department of Pharmacology Institute of Biosciences Universidade Estadual Paulista (UNESP)Department of Clinical Analyses Toxicology and Food Sciences School of Pharmaceutical Sciences University of São Paulo (USP)Department of Morphology Stomatology and Physiology School of Dentistry University of São Paulo (USP)Department of Morphology Institute of Biosciences Universidade Estadual Paulista (UNESP)Department of Pharmacology Institute of Biosciences Universidade Estadual Paulista (UNESP)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Da Silva, Raquel Frenedoso [UNESP]Borges, Cibele Dos Santos [UNESP]VillelaE Silva, Patrícia [UNESP]Missassi, Gabriela [UNESP]Kiguti, Luiz Ricardo Almeida [UNESP]Pupo, André Sampaio [UNESP]Barbosa Junior, FernandoAnselmo-Franci, Janete AparecidaKempinas, Wilma De Grava [UNESP]2018-12-11T17:22:59Z2018-12-11T17:22:59Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2016/4257498Oxidative Medicine and Cellular Longevity, v. 2016.1942-09941942-0900http://hdl.handle.net/11449/17689810.1155/2016/42574982-s2.0-849570840002-s2.0-84957084000.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOxidative Medicine and Cellular Longevity1,5581,558info:eu-repo/semantics/openAccess2023-12-08T06:17:29Zoai:repositorio.unesp.br:11449/176898Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-08T06:17:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system |
title |
The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system |
spellingShingle |
The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system Da Silva, Raquel Frenedoso [UNESP] |
title_short |
The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system |
title_full |
The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system |
title_fullStr |
The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system |
title_full_unstemmed |
The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system |
title_sort |
The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system |
author |
Da Silva, Raquel Frenedoso [UNESP] |
author_facet |
Da Silva, Raquel Frenedoso [UNESP] Borges, Cibele Dos Santos [UNESP] VillelaE Silva, Patrícia [UNESP] Missassi, Gabriela [UNESP] Kiguti, Luiz Ricardo Almeida [UNESP] Pupo, André Sampaio [UNESP] Barbosa Junior, Fernando Anselmo-Franci, Janete Aparecida Kempinas, Wilma De Grava [UNESP] |
author_role |
author |
author2 |
Borges, Cibele Dos Santos [UNESP] VillelaE Silva, Patrícia [UNESP] Missassi, Gabriela [UNESP] Kiguti, Luiz Ricardo Almeida [UNESP] Pupo, André Sampaio [UNESP] Barbosa Junior, Fernando Anselmo-Franci, Janete Aparecida Kempinas, Wilma De Grava [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Da Silva, Raquel Frenedoso [UNESP] Borges, Cibele Dos Santos [UNESP] VillelaE Silva, Patrícia [UNESP] Missassi, Gabriela [UNESP] Kiguti, Luiz Ricardo Almeida [UNESP] Pupo, André Sampaio [UNESP] Barbosa Junior, Fernando Anselmo-Franci, Janete Aparecida Kempinas, Wilma De Grava [UNESP] |
description |
Arsenic trioxide (As2O3) has shown effectiveness in treatment of leukemia but is also associated with reproductive toxicity. Since remediation with N-acetylcysteine (NAC) may mitigate the adverse effects caused by exposure, we assessed the effects of As2O3 and its potential reversibility after exposure cessation or coadministration of NAC. Animals received 0.3 or 3.0 mg/Kg/day of As2O3 subcutaneously and 40 mM of NAC in tap water. As2O3 treatment impaired spermatogenesis and sperm motility and decreased seminal vesicle weight and testosterone serum levels; after suspension of treatment, these parameters remained altered. When NAC was administered, animals showed improvement in sperm parameters and seminal vesicle weight. In vitro epididymal contractility was increased in As2O3-treated animals. We concluded that As2O3 is toxic to the male mouse genital system by compromising sperm quality and quantity; these effects persisted even after suspension of the treatment. However, the coadministration of NAC ameliorates the harmful effects of the drug on the male genital system. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2018-12-11T17:22:59Z 2018-12-11T17:22:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2016/4257498 Oxidative Medicine and Cellular Longevity, v. 2016. 1942-0994 1942-0900 http://hdl.handle.net/11449/176898 10.1155/2016/4257498 2-s2.0-84957084000 2-s2.0-84957084000.pdf |
url |
http://dx.doi.org/10.1155/2016/4257498 http://hdl.handle.net/11449/176898 |
identifier_str_mv |
Oxidative Medicine and Cellular Longevity, v. 2016. 1942-0994 1942-0900 10.1155/2016/4257498 2-s2.0-84957084000 2-s2.0-84957084000.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oxidative Medicine and Cellular Longevity 1,558 1,558 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965208975769600 |