Towards anti-angiogenic activity of NiFe2O4 nanoparticles

Detalhes bibliográficos
Autor(a) principal: Santos, J. G. [UNESP]
Data de Publicação: 2021
Outros Autores: Lopes, H. [UNESP], Moreno, H. [UNESP], Ramirez, M. A. [UNESP], Garcia, F. G., Simões, A. Z. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.ceramint.2021.02.191
http://hdl.handle.net/11449/208501
Resumo: In this study, NiFe2O4 nanoparticles (NPs) were prepared using the polymeric precursor method and calcined at 500°C for 4 h with (S– NiFe2O4) and without (NiFe2O4) CTAB as a surfactant, respectively. The magnetic and biological properties were evaluated based on the (micro)structure and electronic structure of the NPs. On sample S–NiFe2O4, the significant increase in magnetization saturation (Ms ~ 61.84 emu/g), magnetic remanence (Mr ~ 4.30 emu/g), and coercivity (Hc ~ 0.475 kOe) in comparison to sample NiFe2O4 (Ms ~ 24.81 emu/g, Mr ~ 1.00 emu/g, and Hc ~ 0.475 kOe) at room temperature (300 K) may be associated with the presence of oxygen vacancies the spinel lattice of NiFe2O4, generating magnetic moments. The concentration of 1 μg/mL S–NiFe2O4 decreased in ~50% angiogenesis in the chorioallantoic membrane (CAM). S–NiFe2O4 NPs showed high blood vessel affinity and anti-angiogenic activity; hence, effectively concentrating on tumoral vessels, which may enhance drug effectivity and enable simultaneous treatments, image diagnosis of solid tumors, etc. Thus, our results suggest that CTAB addition is an effective way to tune its magnetic response due to its excellent biocompatibility, high bulk saturation magnetization, and low magnetic anisotropy.
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spelling Towards anti-angiogenic activity of NiFe2O4 nanoparticlesAnti-angiogenicNiFe2O4Polymeric precursor methodSurfactantIn this study, NiFe2O4 nanoparticles (NPs) were prepared using the polymeric precursor method and calcined at 500°C for 4 h with (S– NiFe2O4) and without (NiFe2O4) CTAB as a surfactant, respectively. The magnetic and biological properties were evaluated based on the (micro)structure and electronic structure of the NPs. On sample S–NiFe2O4, the significant increase in magnetization saturation (Ms ~ 61.84 emu/g), magnetic remanence (Mr ~ 4.30 emu/g), and coercivity (Hc ~ 0.475 kOe) in comparison to sample NiFe2O4 (Ms ~ 24.81 emu/g, Mr ~ 1.00 emu/g, and Hc ~ 0.475 kOe) at room temperature (300 K) may be associated with the presence of oxygen vacancies the spinel lattice of NiFe2O4, generating magnetic moments. The concentration of 1 μg/mL S–NiFe2O4 decreased in ~50% angiogenesis in the chorioallantoic membrane (CAM). S–NiFe2O4 NPs showed high blood vessel affinity and anti-angiogenic activity; hence, effectively concentrating on tumoral vessels, which may enhance drug effectivity and enable simultaneous treatments, image diagnosis of solid tumors, etc. Thus, our results suggest that CTAB addition is an effective way to tune its magnetic response due to its excellent biocompatibility, high bulk saturation magnetization, and low magnetic anisotropy.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (UNESP) School of Engineering of GuaratinguetáFederal University of Itajubá (UNIFEI) Institute of Physical and Chemistry, Av. BPS, 1303São Paulo State University (UNESP) School of Engineering of GuaratinguetáFAPESP: 2013/07296-2CNPq: 573636/2008-7Universidade Estadual Paulista (Unesp)Institute of Physical and ChemistrySantos, J. G. [UNESP]Lopes, H. [UNESP]Moreno, H. [UNESP]Ramirez, M. A. [UNESP]Garcia, F. G.Simões, A. Z. [UNESP]2021-06-25T11:13:09Z2021-06-25T11:13:09Z2021-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16152-16161http://dx.doi.org/10.1016/j.ceramint.2021.02.191Ceramics International, v. 47, n. 11, p. 16152-16161, 2021.0272-8842http://hdl.handle.net/11449/20850110.1016/j.ceramint.2021.02.1912-s2.0-85102462996Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCeramics Internationalinfo:eu-repo/semantics/openAccess2024-07-02T15:04:15Zoai:repositorio.unesp.br:11449/208501Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:37:08.913892Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Towards anti-angiogenic activity of NiFe2O4 nanoparticles
title Towards anti-angiogenic activity of NiFe2O4 nanoparticles
spellingShingle Towards anti-angiogenic activity of NiFe2O4 nanoparticles
Santos, J. G. [UNESP]
Anti-angiogenic
NiFe2O4
Polymeric precursor method
Surfactant
title_short Towards anti-angiogenic activity of NiFe2O4 nanoparticles
title_full Towards anti-angiogenic activity of NiFe2O4 nanoparticles
title_fullStr Towards anti-angiogenic activity of NiFe2O4 nanoparticles
title_full_unstemmed Towards anti-angiogenic activity of NiFe2O4 nanoparticles
title_sort Towards anti-angiogenic activity of NiFe2O4 nanoparticles
author Santos, J. G. [UNESP]
author_facet Santos, J. G. [UNESP]
Lopes, H. [UNESP]
Moreno, H. [UNESP]
Ramirez, M. A. [UNESP]
Garcia, F. G.
Simões, A. Z. [UNESP]
author_role author
author2 Lopes, H. [UNESP]
Moreno, H. [UNESP]
Ramirez, M. A. [UNESP]
Garcia, F. G.
Simões, A. Z. [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Institute of Physical and Chemistry
dc.contributor.author.fl_str_mv Santos, J. G. [UNESP]
Lopes, H. [UNESP]
Moreno, H. [UNESP]
Ramirez, M. A. [UNESP]
Garcia, F. G.
Simões, A. Z. [UNESP]
dc.subject.por.fl_str_mv Anti-angiogenic
NiFe2O4
Polymeric precursor method
Surfactant
topic Anti-angiogenic
NiFe2O4
Polymeric precursor method
Surfactant
description In this study, NiFe2O4 nanoparticles (NPs) were prepared using the polymeric precursor method and calcined at 500°C for 4 h with (S– NiFe2O4) and without (NiFe2O4) CTAB as a surfactant, respectively. The magnetic and biological properties were evaluated based on the (micro)structure and electronic structure of the NPs. On sample S–NiFe2O4, the significant increase in magnetization saturation (Ms ~ 61.84 emu/g), magnetic remanence (Mr ~ 4.30 emu/g), and coercivity (Hc ~ 0.475 kOe) in comparison to sample NiFe2O4 (Ms ~ 24.81 emu/g, Mr ~ 1.00 emu/g, and Hc ~ 0.475 kOe) at room temperature (300 K) may be associated with the presence of oxygen vacancies the spinel lattice of NiFe2O4, generating magnetic moments. The concentration of 1 μg/mL S–NiFe2O4 decreased in ~50% angiogenesis in the chorioallantoic membrane (CAM). S–NiFe2O4 NPs showed high blood vessel affinity and anti-angiogenic activity; hence, effectively concentrating on tumoral vessels, which may enhance drug effectivity and enable simultaneous treatments, image diagnosis of solid tumors, etc. Thus, our results suggest that CTAB addition is an effective way to tune its magnetic response due to its excellent biocompatibility, high bulk saturation magnetization, and low magnetic anisotropy.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T11:13:09Z
2021-06-25T11:13:09Z
2021-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.ceramint.2021.02.191
Ceramics International, v. 47, n. 11, p. 16152-16161, 2021.
0272-8842
http://hdl.handle.net/11449/208501
10.1016/j.ceramint.2021.02.191
2-s2.0-85102462996
url http://dx.doi.org/10.1016/j.ceramint.2021.02.191
http://hdl.handle.net/11449/208501
identifier_str_mv Ceramics International, v. 47, n. 11, p. 16152-16161, 2021.
0272-8842
10.1016/j.ceramint.2021.02.191
2-s2.0-85102462996
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ceramics International
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16152-16161
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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