Towards anti-angiogenic activity of NiFe2O4 nanoparticles
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ceramint.2021.02.191 http://hdl.handle.net/11449/208501 |
Resumo: | In this study, NiFe2O4 nanoparticles (NPs) were prepared using the polymeric precursor method and calcined at 500°C for 4 h with (S– NiFe2O4) and without (NiFe2O4) CTAB as a surfactant, respectively. The magnetic and biological properties were evaluated based on the (micro)structure and electronic structure of the NPs. On sample S–NiFe2O4, the significant increase in magnetization saturation (Ms ~ 61.84 emu/g), magnetic remanence (Mr ~ 4.30 emu/g), and coercivity (Hc ~ 0.475 kOe) in comparison to sample NiFe2O4 (Ms ~ 24.81 emu/g, Mr ~ 1.00 emu/g, and Hc ~ 0.475 kOe) at room temperature (300 K) may be associated with the presence of oxygen vacancies the spinel lattice of NiFe2O4, generating magnetic moments. The concentration of 1 μg/mL S–NiFe2O4 decreased in ~50% angiogenesis in the chorioallantoic membrane (CAM). S–NiFe2O4 NPs showed high blood vessel affinity and anti-angiogenic activity; hence, effectively concentrating on tumoral vessels, which may enhance drug effectivity and enable simultaneous treatments, image diagnosis of solid tumors, etc. Thus, our results suggest that CTAB addition is an effective way to tune its magnetic response due to its excellent biocompatibility, high bulk saturation magnetization, and low magnetic anisotropy. |
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Towards anti-angiogenic activity of NiFe2O4 nanoparticlesAnti-angiogenicNiFe2O4Polymeric precursor methodSurfactantIn this study, NiFe2O4 nanoparticles (NPs) were prepared using the polymeric precursor method and calcined at 500°C for 4 h with (S– NiFe2O4) and without (NiFe2O4) CTAB as a surfactant, respectively. The magnetic and biological properties were evaluated based on the (micro)structure and electronic structure of the NPs. On sample S–NiFe2O4, the significant increase in magnetization saturation (Ms ~ 61.84 emu/g), magnetic remanence (Mr ~ 4.30 emu/g), and coercivity (Hc ~ 0.475 kOe) in comparison to sample NiFe2O4 (Ms ~ 24.81 emu/g, Mr ~ 1.00 emu/g, and Hc ~ 0.475 kOe) at room temperature (300 K) may be associated with the presence of oxygen vacancies the spinel lattice of NiFe2O4, generating magnetic moments. The concentration of 1 μg/mL S–NiFe2O4 decreased in ~50% angiogenesis in the chorioallantoic membrane (CAM). S–NiFe2O4 NPs showed high blood vessel affinity and anti-angiogenic activity; hence, effectively concentrating on tumoral vessels, which may enhance drug effectivity and enable simultaneous treatments, image diagnosis of solid tumors, etc. Thus, our results suggest that CTAB addition is an effective way to tune its magnetic response due to its excellent biocompatibility, high bulk saturation magnetization, and low magnetic anisotropy.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (UNESP) School of Engineering of GuaratinguetáFederal University of Itajubá (UNIFEI) Institute of Physical and Chemistry, Av. BPS, 1303São Paulo State University (UNESP) School of Engineering of GuaratinguetáFAPESP: 2013/07296-2CNPq: 573636/2008-7Universidade Estadual Paulista (Unesp)Institute of Physical and ChemistrySantos, J. G. [UNESP]Lopes, H. [UNESP]Moreno, H. [UNESP]Ramirez, M. A. [UNESP]Garcia, F. G.Simões, A. Z. [UNESP]2021-06-25T11:13:09Z2021-06-25T11:13:09Z2021-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16152-16161http://dx.doi.org/10.1016/j.ceramint.2021.02.191Ceramics International, v. 47, n. 11, p. 16152-16161, 2021.0272-8842http://hdl.handle.net/11449/20850110.1016/j.ceramint.2021.02.1912-s2.0-85102462996Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCeramics Internationalinfo:eu-repo/semantics/openAccess2024-07-02T15:04:15Zoai:repositorio.unesp.br:11449/208501Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:37:08.913892Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Towards anti-angiogenic activity of NiFe2O4 nanoparticles |
title |
Towards anti-angiogenic activity of NiFe2O4 nanoparticles |
spellingShingle |
Towards anti-angiogenic activity of NiFe2O4 nanoparticles Santos, J. G. [UNESP] Anti-angiogenic NiFe2O4 Polymeric precursor method Surfactant |
title_short |
Towards anti-angiogenic activity of NiFe2O4 nanoparticles |
title_full |
Towards anti-angiogenic activity of NiFe2O4 nanoparticles |
title_fullStr |
Towards anti-angiogenic activity of NiFe2O4 nanoparticles |
title_full_unstemmed |
Towards anti-angiogenic activity of NiFe2O4 nanoparticles |
title_sort |
Towards anti-angiogenic activity of NiFe2O4 nanoparticles |
author |
Santos, J. G. [UNESP] |
author_facet |
Santos, J. G. [UNESP] Lopes, H. [UNESP] Moreno, H. [UNESP] Ramirez, M. A. [UNESP] Garcia, F. G. Simões, A. Z. [UNESP] |
author_role |
author |
author2 |
Lopes, H. [UNESP] Moreno, H. [UNESP] Ramirez, M. A. [UNESP] Garcia, F. G. Simões, A. Z. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Institute of Physical and Chemistry |
dc.contributor.author.fl_str_mv |
Santos, J. G. [UNESP] Lopes, H. [UNESP] Moreno, H. [UNESP] Ramirez, M. A. [UNESP] Garcia, F. G. Simões, A. Z. [UNESP] |
dc.subject.por.fl_str_mv |
Anti-angiogenic NiFe2O4 Polymeric precursor method Surfactant |
topic |
Anti-angiogenic NiFe2O4 Polymeric precursor method Surfactant |
description |
In this study, NiFe2O4 nanoparticles (NPs) were prepared using the polymeric precursor method and calcined at 500°C for 4 h with (S– NiFe2O4) and without (NiFe2O4) CTAB as a surfactant, respectively. The magnetic and biological properties were evaluated based on the (micro)structure and electronic structure of the NPs. On sample S–NiFe2O4, the significant increase in magnetization saturation (Ms ~ 61.84 emu/g), magnetic remanence (Mr ~ 4.30 emu/g), and coercivity (Hc ~ 0.475 kOe) in comparison to sample NiFe2O4 (Ms ~ 24.81 emu/g, Mr ~ 1.00 emu/g, and Hc ~ 0.475 kOe) at room temperature (300 K) may be associated with the presence of oxygen vacancies the spinel lattice of NiFe2O4, generating magnetic moments. The concentration of 1 μg/mL S–NiFe2O4 decreased in ~50% angiogenesis in the chorioallantoic membrane (CAM). S–NiFe2O4 NPs showed high blood vessel affinity and anti-angiogenic activity; hence, effectively concentrating on tumoral vessels, which may enhance drug effectivity and enable simultaneous treatments, image diagnosis of solid tumors, etc. Thus, our results suggest that CTAB addition is an effective way to tune its magnetic response due to its excellent biocompatibility, high bulk saturation magnetization, and low magnetic anisotropy. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:13:09Z 2021-06-25T11:13:09Z 2021-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ceramint.2021.02.191 Ceramics International, v. 47, n. 11, p. 16152-16161, 2021. 0272-8842 http://hdl.handle.net/11449/208501 10.1016/j.ceramint.2021.02.191 2-s2.0-85102462996 |
url |
http://dx.doi.org/10.1016/j.ceramint.2021.02.191 http://hdl.handle.net/11449/208501 |
identifier_str_mv |
Ceramics International, v. 47, n. 11, p. 16152-16161, 2021. 0272-8842 10.1016/j.ceramint.2021.02.191 2-s2.0-85102462996 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ceramics International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16152-16161 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129444030709760 |