Treating juvenile idiopathic arthritis to target: Recommendations of an international task force

Detalhes bibliográficos
Autor(a) principal: Ravelli, Angelo
Data de Publicação: 2018
Outros Autores: Consolaro, Alessandro, Horneff, Gerd, Laxer, Ronald M., Lovell, Daniel J., Wulffraat, Nico M., Akikusa, Jonathan D., Al-Mayouf, Sulaiman M., Antón, Jordi, Avcin, Tadej, Berard, Roberta A., Beresford, Michael W., Burgos-Vargas, Ruben, Cimaz, Rolando, De Benedetti, Fabrizio, Demirkaya, Erkan, Foell, Dirk, Itoh, Yasuhiko, Lahdenne, Pekka, Morgan, Esi M., Quartier, Pierre, Ruperto, Nicolino, Russo, Ricardo, Saad-Magalhães, Claudia [UNESP], Sawhney, Sujata, Scott, Christiaan, Shenoi, Susan, Swart, Joost F., Uziel, Yosef, Vastert, Sebastiaan J., Smolen, Josef S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1136/annrheumdis-2018-213030
http://hdl.handle.net/11449/171016
Resumo: Recent therapeutic advances in juvenile idiopathic arthritis (JIA) have made remission an achievable goal for most patients. Reaching this target leads to improved outcomes. The objective was to develop recommendations for treating JIA to target. A Steering Committee formulated a set of recommendations based on evidence derived from a systematic literature review. These were subsequently discussed, amended and voted on by an international Task Force of 30 paediatric rheumatologists in a consensus-based, Delphi-like procedure. Although the literature review did not reveal trials that compared a treat-to-target approach with another or no strategy, it provided indirect evidence regarding an optimised approach to therapy that facilitated development of recommendations. The group agreed on six overarching principles and eight recommendations. The main treatment target, which should be based on a shared decision with parents/patients, was defined as remission, with the alternative target of low disease activity. The frequency and timeline of follow-up evaluations to ensure achievement and maintenance of the target depend on JIA category and level of disease activity. Additional recommendations emphasise the importance of ensuring adequate growth and development and avoiding long-term systemic glucocorticoid administration to maintain the target. All items were agreed on by more than 80% of the members of the Task Force. A research agenda was formulated. The Task Force developed recommendations for treating JIA to target, being aware that the evidence is not strong and needs to be expanded by future research. These recommendations can inform various stakeholders about strategies to reach optimal outcomes for JIA.
id UNSP_ecde7a9d5069de489f971cacc1bed808
oai_identifier_str oai:repositorio.unesp.br:11449/171016
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Treating juvenile idiopathic arthritis to target: Recommendations of an international task forcejuvenile idiopathic arthritisoutcomes researchtreatmentRecent therapeutic advances in juvenile idiopathic arthritis (JIA) have made remission an achievable goal for most patients. Reaching this target leads to improved outcomes. The objective was to develop recommendations for treating JIA to target. A Steering Committee formulated a set of recommendations based on evidence derived from a systematic literature review. These were subsequently discussed, amended and voted on by an international Task Force of 30 paediatric rheumatologists in a consensus-based, Delphi-like procedure. Although the literature review did not reveal trials that compared a treat-to-target approach with another or no strategy, it provided indirect evidence regarding an optimised approach to therapy that facilitated development of recommendations. The group agreed on six overarching principles and eight recommendations. The main treatment target, which should be based on a shared decision with parents/patients, was defined as remission, with the alternative target of low disease activity. The frequency and timeline of follow-up evaluations to ensure achievement and maintenance of the target depend on JIA category and level of disease activity. Additional recommendations emphasise the importance of ensuring adequate growth and development and avoiding long-term systemic glucocorticoid administration to maintain the target. All items were agreed on by more than 80% of the members of the Task Force. A research agenda was formulated. The Task Force developed recommendations for treating JIA to target, being aware that the evidence is not strong and needs to be expanded by future research. These recommendations can inform various stakeholders about strategies to reach optimal outcomes for JIA.Clinica Pediatrica e Reumatologia Università degli Studi di Genova Istituto di Ricovero e Cura a Carattere Scientifico Istituto GianninaDepartment of Pediatrics Asklepios Klinik Sankt AugustinDepartment of Pediatric and Adolescents Medicine University Hospital of CologneDivision od Rheumatology University of Toronto Hospital for Sick ChildrenDivision of Rheumatology Cincinnati Children's Hospital Medical Center University of CincinnatiDepartment of Paediatric Immunology Wilhelmina Children's Hospital University Medical Center Utrecht University of UtrechtRheumatology Unit Department of General Medicine Royal Children's Hospital Murdoch Children's Research InstituteDepartment of Pediatric Rheumatology King Faisal Specialist Hospital and Research Center Alfaisal UniversityDivision of Pediatric Rheumatology Hospital Sant Joan de Déu Universitat de BarcelonaDepartment of Allergology Rheumatology and Clinical Immunology University Medical Center Ljubljana Medical Faculty University of LjubljanaDivision of Rheumatology Western University Children's Hospital London Health Sciences CentreInstitute of Translational Medicine University of Liverpool Alder Hey Children's NHS Foundation TrustRheumatology Department Hospital General de México Eduardo LiceagaPediatric Rheumatology Azienda Ospedaliero Universitaria MeyerDivision of Rheumatology Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Pediatrico Bambino GesùPediatric Rheumatology and Immunology University of MuensterDepartment of Pediatrics Nippon Medical SchoolInstitute of Clinical Medicine Children's Hospital Helsinki University HospitalParis-Descartes University IMAGINE Institute RAISE 22 National Reference Centre Necker-Enfants Malades Hospital Assistance Publique Hopitaux de ParisClinica Pediatrica e Reumatologia Istituto di Ricovero e Cura a Carattere Scientifico Istituto Giannina GasliniServicio de Inmunología y Reumatología Hospital de Pediatría GarrahanReumatologia Pediátrica São Paulo State University (UNESP)Department of Rheumatology ISIC Superspeciality Hospital Sir Ganga Ram HospitalRed Cross War Memorial Children's Hospital University of Cape TownPediatric Rheumatology Seattle Children's Hospital and Research Center University of WashingtonPediatric Rheumatology Unit Department of Pediatrics Meir Medical CenterTel Aviv University Sackler School of MedicineDivision of Rheumatology Department of Medicine3 Medical University of ViennaReumatologia Pediátrica São Paulo State University (UNESP)Istituto GianninaAsklepios Klinik Sankt AugustinUniversity Hospital of CologneHospital for Sick ChildrenUniversity of CincinnatiUniversity of UtrechtMurdoch Children's Research InstituteAlfaisal UniversityUniversitat de BarcelonaUniversity of LjubljanaLondon Health Sciences CentreAlder Hey Children's NHS Foundation TrustHospital General de México Eduardo LiceagaAzienda Ospedaliero Universitaria MeyerOspedale Pediatrico Bambino GesùUniversity of MuensterNippon Medical SchoolHelsinki University HospitalAssistance Publique Hopitaux de ParisIstituto Giannina GasliniHospital de Pediatría GarrahanUniversidade Estadual Paulista (Unesp)Sir Ganga Ram HospitalUniversity of Cape TownUniversity of WashingtonMeir Medical CenterTel Aviv University Sackler School of MedicineMedical University of ViennaRavelli, AngeloConsolaro, AlessandroHorneff, GerdLaxer, Ronald M.Lovell, Daniel J.Wulffraat, Nico M.Akikusa, Jonathan D.Al-Mayouf, Sulaiman M.Antón, JordiAvcin, TadejBerard, Roberta A.Beresford, Michael W.Burgos-Vargas, RubenCimaz, RolandoDe Benedetti, FabrizioDemirkaya, ErkanFoell, DirkItoh, YasuhikoLahdenne, PekkaMorgan, Esi M.Quartier, PierreRuperto, NicolinoRusso, RicardoSaad-Magalhães, Claudia [UNESP]Sawhney, SujataScott, ChristiaanShenoi, SusanSwart, Joost F.Uziel, YosefVastert, Sebastiaan J.Smolen, Josef S.2018-12-11T16:53:21Z2018-12-11T16:53:21Z2018-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article819-828application/pdfhttp://dx.doi.org/10.1136/annrheumdis-2018-213030Annals of the Rheumatic Diseases, v. 77, n. 6, p. 819-828, 2018.1468-20600003-4967http://hdl.handle.net/11449/17101610.1136/annrheumdis-2018-2130302-s2.0-850472726172-s2.0-85047272617.pdf70983100083716320000-0002-7631-7093Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnnals of the Rheumatic Diseases7,6997,699info:eu-repo/semantics/openAccess2023-12-10T06:15:02Zoai:repositorio.unesp.br:11449/171016Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:53:33.722029Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Treating juvenile idiopathic arthritis to target: Recommendations of an international task force
title Treating juvenile idiopathic arthritis to target: Recommendations of an international task force
spellingShingle Treating juvenile idiopathic arthritis to target: Recommendations of an international task force
Ravelli, Angelo
juvenile idiopathic arthritis
outcomes research
treatment
title_short Treating juvenile idiopathic arthritis to target: Recommendations of an international task force
title_full Treating juvenile idiopathic arthritis to target: Recommendations of an international task force
title_fullStr Treating juvenile idiopathic arthritis to target: Recommendations of an international task force
title_full_unstemmed Treating juvenile idiopathic arthritis to target: Recommendations of an international task force
title_sort Treating juvenile idiopathic arthritis to target: Recommendations of an international task force
author Ravelli, Angelo
author_facet Ravelli, Angelo
Consolaro, Alessandro
Horneff, Gerd
Laxer, Ronald M.
Lovell, Daniel J.
Wulffraat, Nico M.
Akikusa, Jonathan D.
Al-Mayouf, Sulaiman M.
Antón, Jordi
Avcin, Tadej
Berard, Roberta A.
Beresford, Michael W.
Burgos-Vargas, Ruben
Cimaz, Rolando
De Benedetti, Fabrizio
Demirkaya, Erkan
Foell, Dirk
Itoh, Yasuhiko
Lahdenne, Pekka
Morgan, Esi M.
Quartier, Pierre
Ruperto, Nicolino
Russo, Ricardo
Saad-Magalhães, Claudia [UNESP]
Sawhney, Sujata
Scott, Christiaan
Shenoi, Susan
Swart, Joost F.
Uziel, Yosef
Vastert, Sebastiaan J.
Smolen, Josef S.
author_role author
author2 Consolaro, Alessandro
Horneff, Gerd
Laxer, Ronald M.
Lovell, Daniel J.
Wulffraat, Nico M.
Akikusa, Jonathan D.
Al-Mayouf, Sulaiman M.
Antón, Jordi
Avcin, Tadej
Berard, Roberta A.
Beresford, Michael W.
Burgos-Vargas, Ruben
Cimaz, Rolando
De Benedetti, Fabrizio
Demirkaya, Erkan
Foell, Dirk
Itoh, Yasuhiko
Lahdenne, Pekka
Morgan, Esi M.
Quartier, Pierre
Ruperto, Nicolino
Russo, Ricardo
Saad-Magalhães, Claudia [UNESP]
Sawhney, Sujata
Scott, Christiaan
Shenoi, Susan
Swart, Joost F.
Uziel, Yosef
Vastert, Sebastiaan J.
Smolen, Josef S.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Istituto Giannina
Asklepios Klinik Sankt Augustin
University Hospital of Cologne
Hospital for Sick Children
University of Cincinnati
University of Utrecht
Murdoch Children's Research Institute
Alfaisal University
Universitat de Barcelona
University of Ljubljana
London Health Sciences Centre
Alder Hey Children's NHS Foundation Trust
Hospital General de México Eduardo Liceaga
Azienda Ospedaliero Universitaria Meyer
Ospedale Pediatrico Bambino Gesù
University of Muenster
Nippon Medical School
Helsinki University Hospital
Assistance Publique Hopitaux de Paris
Istituto Giannina Gaslini
Hospital de Pediatría Garrahan
Universidade Estadual Paulista (Unesp)
Sir Ganga Ram Hospital
University of Cape Town
University of Washington
Meir Medical Center
Tel Aviv University Sackler School of Medicine
Medical University of Vienna
dc.contributor.author.fl_str_mv Ravelli, Angelo
Consolaro, Alessandro
Horneff, Gerd
Laxer, Ronald M.
Lovell, Daniel J.
Wulffraat, Nico M.
Akikusa, Jonathan D.
Al-Mayouf, Sulaiman M.
Antón, Jordi
Avcin, Tadej
Berard, Roberta A.
Beresford, Michael W.
Burgos-Vargas, Ruben
Cimaz, Rolando
De Benedetti, Fabrizio
Demirkaya, Erkan
Foell, Dirk
Itoh, Yasuhiko
Lahdenne, Pekka
Morgan, Esi M.
Quartier, Pierre
Ruperto, Nicolino
Russo, Ricardo
Saad-Magalhães, Claudia [UNESP]
Sawhney, Sujata
Scott, Christiaan
Shenoi, Susan
Swart, Joost F.
Uziel, Yosef
Vastert, Sebastiaan J.
Smolen, Josef S.
dc.subject.por.fl_str_mv juvenile idiopathic arthritis
outcomes research
treatment
topic juvenile idiopathic arthritis
outcomes research
treatment
description Recent therapeutic advances in juvenile idiopathic arthritis (JIA) have made remission an achievable goal for most patients. Reaching this target leads to improved outcomes. The objective was to develop recommendations for treating JIA to target. A Steering Committee formulated a set of recommendations based on evidence derived from a systematic literature review. These were subsequently discussed, amended and voted on by an international Task Force of 30 paediatric rheumatologists in a consensus-based, Delphi-like procedure. Although the literature review did not reveal trials that compared a treat-to-target approach with another or no strategy, it provided indirect evidence regarding an optimised approach to therapy that facilitated development of recommendations. The group agreed on six overarching principles and eight recommendations. The main treatment target, which should be based on a shared decision with parents/patients, was defined as remission, with the alternative target of low disease activity. The frequency and timeline of follow-up evaluations to ensure achievement and maintenance of the target depend on JIA category and level of disease activity. Additional recommendations emphasise the importance of ensuring adequate growth and development and avoiding long-term systemic glucocorticoid administration to maintain the target. All items were agreed on by more than 80% of the members of the Task Force. A research agenda was formulated. The Task Force developed recommendations for treating JIA to target, being aware that the evidence is not strong and needs to be expanded by future research. These recommendations can inform various stakeholders about strategies to reach optimal outcomes for JIA.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T16:53:21Z
2018-12-11T16:53:21Z
2018-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1136/annrheumdis-2018-213030
Annals of the Rheumatic Diseases, v. 77, n. 6, p. 819-828, 2018.
1468-2060
0003-4967
http://hdl.handle.net/11449/171016
10.1136/annrheumdis-2018-213030
2-s2.0-85047272617
2-s2.0-85047272617.pdf
7098310008371632
0000-0002-7631-7093
url http://dx.doi.org/10.1136/annrheumdis-2018-213030
http://hdl.handle.net/11449/171016
identifier_str_mv Annals of the Rheumatic Diseases, v. 77, n. 6, p. 819-828, 2018.
1468-2060
0003-4967
10.1136/annrheumdis-2018-213030
2-s2.0-85047272617
2-s2.0-85047272617.pdf
7098310008371632
0000-0002-7631-7093
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Annals of the Rheumatic Diseases
7,699
7,699
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 819-828
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129135161114624