Determination of ambroxol in syrups using diffuse reflectance spectroscopy

• Autor(a) principal: Rufino, José L. [UNESP]
• Data de Publicação: 2009
• Outros Autores: Santos, Joel M. [UNESP], Rodrigues, Mayra A. [UNESP], Pezza, Helena Redigolo [UNESP], Pezza, Leonardo [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/S0100-40422009000600029; http://hdl.handle.net/11449/26294
• topic: ambroxol; diffuse reflectance spectroscopy; p-dimethylaminocinnamaldehyde

This paper reports an analytical method for the determination of ambroxol in micellar medium by spot test-diffuse reflectance spectroscopy. The reflectance measurements were performed analyzing the colored compound (λ= 520 nm) produced from the reaction between ambroxol and p-dimethylaminocinnamaldehyde on the surface filter paper. The linear range was from 1.21 × 103 to 9.65 × 103 mol L-1 (500 - 4000 μg mL-1). The limit of detection and quantification were 3.50 x 10-4 mol L-1 (145 μg mL-1) and 1.16 x 10-3 mol L-1 (481 μg mL-1), respectively. Five commercial samples were analysed and the results obtained by the proposed method were in good agreement with those obtained by the literature method at 95% confidence level.