HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1995/V64N2/64020007.pdf http://hdl.handle.net/11449/64559 |
Resumo: | Purpose. To evaluate the effects of captopril (Cpt) on carbohydrate metabolism and growth hormone (GH) in adults hypertensive obese patients with normal (NGT) or impaired (IGT) glucose tolerance and left ventricular hypertrophy. Methods. Ten patients (53 ± 8 years), 8 women and 2 men, white, body mass index (BMI) ≥ 26 kg/m2, left ventricular mass index (LVMI) > 135 g/m2 in man and > 110 g/m2 in woman, with diastolic blood pressure (DBP) 95-115 mmHg after 3 weeks of placebo, were identified by oral glucose tolerance test (OGTT-75 g) as either with NGT or IGT, and treated with Cpt 25 mg t.i.d. for 8 weeks. At the 8 weeks, dosage was increased to 50 mg b.i.d. if DBP > 90 mmHg or the decrease of the DBP < 10%, during the next 8 weeks. OGTT and clonidine tests (0,04 mg/kg) with determinations, every 30 minutes of glucose, insulin, and GH during 2 hours, were performed. Results. Cpt lowered SBP and DBP in the NGT group and IGT group. The LVMI and the left ventricular mass (LVM) decreased in the IGT group with no significant change in the NGT group. Cpt promoted in the IGT group decrease in the area under the curve (AUC) of glucose, and AUC of insulin, with increase of the AUC of the percent of the β cell function, AUC of HC, and insulin sensitivity index with no significantly change in the NGT group. Conclusion. Adults hypertensive obese patients with IGT had decreased significantly in mean fasting level of GH concentrations compared to age, race, and BMI matched hypertensive patients with NGT. Treatment with Cpt induced a significant increased of the GH, with improvement of the metabolism in patients with IGT. |
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HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTOHypertension in obese patients with cardiac hypertrophy. Effects of captopril in the insulin sensitivity and growth hormonecaptoprilglucose tolerancegrowth hormoneinsulinantihypertensive agentlipidadultblood pressurecarbohydrate metabolismclinical articleclinical trialfemaleheart hypertrophyheart left ventricle hypertrophyhumanhypertensioninsulin sensitivitymaleobesityagedbloodglucose blood levelglucose intoleranceglucose tolerance testinsulin resistancetimeAdultAgedAntihypertensive AgentsBlood GlucoseCaptoprilEnglish AbstractFemaleGlucose IntoleranceGlucose Tolerance TestGrowth HormoneHumanHypertensionHypertrophy, Left VentricularInsulinInsulin ResistanceLipidsMaleMiddle AgeObesitySupport, Non-U.S. Gov'tTime FactorsPurpose. To evaluate the effects of captopril (Cpt) on carbohydrate metabolism and growth hormone (GH) in adults hypertensive obese patients with normal (NGT) or impaired (IGT) glucose tolerance and left ventricular hypertrophy. Methods. Ten patients (53 ± 8 years), 8 women and 2 men, white, body mass index (BMI) ≥ 26 kg/m2, left ventricular mass index (LVMI) > 135 g/m2 in man and > 110 g/m2 in woman, with diastolic blood pressure (DBP) 95-115 mmHg after 3 weeks of placebo, were identified by oral glucose tolerance test (OGTT-75 g) as either with NGT or IGT, and treated with Cpt 25 mg t.i.d. for 8 weeks. At the 8 weeks, dosage was increased to 50 mg b.i.d. if DBP > 90 mmHg or the decrease of the DBP < 10%, during the next 8 weeks. OGTT and clonidine tests (0,04 mg/kg) with determinations, every 30 minutes of glucose, insulin, and GH during 2 hours, were performed. Results. Cpt lowered SBP and DBP in the NGT group and IGT group. The LVMI and the left ventricular mass (LVM) decreased in the IGT group with no significant change in the NGT group. Cpt promoted in the IGT group decrease in the area under the curve (AUC) of glucose, and AUC of insulin, with increase of the AUC of the percent of the β cell function, AUC of HC, and insulin sensitivity index with no significantly change in the NGT group. Conclusion. Adults hypertensive obese patients with IGT had decreased significantly in mean fasting level of GH concentrations compared to age, race, and BMI matched hypertensive patients with NGT. Treatment with Cpt induced a significant increased of the GH, with improvement of the metabolism in patients with IGT.Depto. de Clinica Medica Faculdade de Medicina UNESP, 18618-000 Botucatu, SPDepto. de Clinica Medica Faculdade de Medicina UNESP, 18618-000 Botucatu, SPUniversidade Estadual Paulista (Unesp)Velasco-Conejo, I. F. [UNESP]Martin, Luis Cuadrado [UNESP]Brandao-Neto, J. [UNESP]Marchioli, M. [UNESP]De Barros e Silva, M. [UNESP]De Cassia Athanazio-Heliodoro, R. [UNESP]Da Silva Franco, R. J. [UNESP]2014-05-27T11:17:59Z2014-05-27T11:17:59Z1995-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article125-132application/pdfhttp://www.arquivosonline.com.br/pesquisartigos/Pdfs/1995/V64N2/64020007.pdfArquivos Brasileiros de Cardiologia, v. 64, n. 2, p. 125-132, 1995.0066-782Xhttp://hdl.handle.net/11449/645592-s2.0-00288982552-s2.0-0028898255.pdf70959335578551514923203168446615Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos Brasileiros de Cardiologia1.318info:eu-repo/semantics/openAccess2024-01-22T06:25:46Zoai:repositorio.unesp.br:11449/64559Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-22T06:25:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO Hypertension in obese patients with cardiac hypertrophy. Effects of captopril in the insulin sensitivity and growth hormone |
title |
HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO |
spellingShingle |
HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO Velasco-Conejo, I. F. [UNESP] captopril glucose tolerance growth hormone insulin antihypertensive agent lipid adult blood pressure carbohydrate metabolism clinical article clinical trial female heart hypertrophy heart left ventricle hypertrophy human hypertension insulin sensitivity male obesity aged blood glucose blood level glucose intolerance glucose tolerance test insulin resistance time Adult Aged Antihypertensive Agents Blood Glucose Captopril English Abstract Female Glucose Intolerance Glucose Tolerance Test Growth Hormone Human Hypertension Hypertrophy, Left Ventricular Insulin Insulin Resistance Lipids Male Middle Age Obesity Support, Non-U.S. Gov't Time Factors |
title_short |
HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO |
title_full |
HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO |
title_fullStr |
HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO |
title_full_unstemmed |
HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO |
title_sort |
HIPERTENSAO ARTERIAL EM PACIENTES OBESOS COM HIPERTROFIA CARDIACA. EFEITOS DO CAPTOPRIL SOBRE A SENSIBILIDADE A INSULINA E HORMONIO DE CRESCIMENTO |
author |
Velasco-Conejo, I. F. [UNESP] |
author_facet |
Velasco-Conejo, I. F. [UNESP] Martin, Luis Cuadrado [UNESP] Brandao-Neto, J. [UNESP] Marchioli, M. [UNESP] De Barros e Silva, M. [UNESP] De Cassia Athanazio-Heliodoro, R. [UNESP] Da Silva Franco, R. J. [UNESP] |
author_role |
author |
author2 |
Martin, Luis Cuadrado [UNESP] Brandao-Neto, J. [UNESP] Marchioli, M. [UNESP] De Barros e Silva, M. [UNESP] De Cassia Athanazio-Heliodoro, R. [UNESP] Da Silva Franco, R. J. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Velasco-Conejo, I. F. [UNESP] Martin, Luis Cuadrado [UNESP] Brandao-Neto, J. [UNESP] Marchioli, M. [UNESP] De Barros e Silva, M. [UNESP] De Cassia Athanazio-Heliodoro, R. [UNESP] Da Silva Franco, R. J. [UNESP] |
dc.subject.por.fl_str_mv |
captopril glucose tolerance growth hormone insulin antihypertensive agent lipid adult blood pressure carbohydrate metabolism clinical article clinical trial female heart hypertrophy heart left ventricle hypertrophy human hypertension insulin sensitivity male obesity aged blood glucose blood level glucose intolerance glucose tolerance test insulin resistance time Adult Aged Antihypertensive Agents Blood Glucose Captopril English Abstract Female Glucose Intolerance Glucose Tolerance Test Growth Hormone Human Hypertension Hypertrophy, Left Ventricular Insulin Insulin Resistance Lipids Male Middle Age Obesity Support, Non-U.S. Gov't Time Factors |
topic |
captopril glucose tolerance growth hormone insulin antihypertensive agent lipid adult blood pressure carbohydrate metabolism clinical article clinical trial female heart hypertrophy heart left ventricle hypertrophy human hypertension insulin sensitivity male obesity aged blood glucose blood level glucose intolerance glucose tolerance test insulin resistance time Adult Aged Antihypertensive Agents Blood Glucose Captopril English Abstract Female Glucose Intolerance Glucose Tolerance Test Growth Hormone Human Hypertension Hypertrophy, Left Ventricular Insulin Insulin Resistance Lipids Male Middle Age Obesity Support, Non-U.S. Gov't Time Factors |
description |
Purpose. To evaluate the effects of captopril (Cpt) on carbohydrate metabolism and growth hormone (GH) in adults hypertensive obese patients with normal (NGT) or impaired (IGT) glucose tolerance and left ventricular hypertrophy. Methods. Ten patients (53 ± 8 years), 8 women and 2 men, white, body mass index (BMI) ≥ 26 kg/m2, left ventricular mass index (LVMI) > 135 g/m2 in man and > 110 g/m2 in woman, with diastolic blood pressure (DBP) 95-115 mmHg after 3 weeks of placebo, were identified by oral glucose tolerance test (OGTT-75 g) as either with NGT or IGT, and treated with Cpt 25 mg t.i.d. for 8 weeks. At the 8 weeks, dosage was increased to 50 mg b.i.d. if DBP > 90 mmHg or the decrease of the DBP < 10%, during the next 8 weeks. OGTT and clonidine tests (0,04 mg/kg) with determinations, every 30 minutes of glucose, insulin, and GH during 2 hours, were performed. Results. Cpt lowered SBP and DBP in the NGT group and IGT group. The LVMI and the left ventricular mass (LVM) decreased in the IGT group with no significant change in the NGT group. Cpt promoted in the IGT group decrease in the area under the curve (AUC) of glucose, and AUC of insulin, with increase of the AUC of the percent of the β cell function, AUC of HC, and insulin sensitivity index with no significantly change in the NGT group. Conclusion. Adults hypertensive obese patients with IGT had decreased significantly in mean fasting level of GH concentrations compared to age, race, and BMI matched hypertensive patients with NGT. Treatment with Cpt induced a significant increased of the GH, with improvement of the metabolism in patients with IGT. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-01-01 2014-05-27T11:17:59Z 2014-05-27T11:17:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1995/V64N2/64020007.pdf Arquivos Brasileiros de Cardiologia, v. 64, n. 2, p. 125-132, 1995. 0066-782X http://hdl.handle.net/11449/64559 2-s2.0-0028898255 2-s2.0-0028898255.pdf 7095933557855151 4923203168446615 |
url |
http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1995/V64N2/64020007.pdf http://hdl.handle.net/11449/64559 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia, v. 64, n. 2, p. 125-132, 1995. 0066-782X 2-s2.0-0028898255 2-s2.0-0028898255.pdf 7095933557855151 4923203168446615 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia 1.318 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
125-132 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1803047400834596864 |