Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sciencedirect.com/science/article/pii/S2214024714000574 http://hdl.handle.net/11449/122712 |
Resumo: | This study was undertaken to assess the frequency of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in patients with type 2 diabetes mellitus. A total of 162 patients with type 2 diabetes and 160 individuals without this disease were analyzed. From the diabetes group, 81 patients with cardiovascular risk (according to American Diabetes Association parameters) were selected to form another subgroup. For polymorphism identification, two polymerase chain reactions were performed: one reaction to identify all genotypes and a second one to confirm the presence of the I allele. The observed genotype frequencies were as follows: diabetes group I/I (19.1%), I/D (52.5%), D/D (28.4%); control group I/I (12.5%), I/D (55.6%), D/D (31.9%); and diabetes with cardiovascular risk group I/I (16.0%), I/ D (59.3%), D/D (24.7%). No statistically significant difference was observed between the allelic and genotypic frequencies in the analyzed groups. Previous studies reported an association between the D allele and type 2 diabetes in Caucasian and East Asian populations. However, in mixed populations, such as those found in Brazil, such an association was not found. This fact does not discard the need for more studies on the frequencies of this polymorphism in the Brazilian population and the associations with risk factors, which can compromise the quality of life of diabetes patients |
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Angiotensin converting enzyme polymorphism in type 2 diabetes mellitusACE polymorphismangiotensin converting enzyme polymorphismgenetic polymorphismI/D polymorphismtype 2 diabetThis study was undertaken to assess the frequency of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in patients with type 2 diabetes mellitus. A total of 162 patients with type 2 diabetes and 160 individuals without this disease were analyzed. From the diabetes group, 81 patients with cardiovascular risk (according to American Diabetes Association parameters) were selected to form another subgroup. For polymorphism identification, two polymerase chain reactions were performed: one reaction to identify all genotypes and a second one to confirm the presence of the I allele. The observed genotype frequencies were as follows: diabetes group I/I (19.1%), I/D (52.5%), D/D (28.4%); control group I/I (12.5%), I/D (55.6%), D/D (31.9%); and diabetes with cardiovascular risk group I/I (16.0%), I/ D (59.3%), D/D (24.7%). No statistically significant difference was observed between the allelic and genotypic frequencies in the analyzed groups. Previous studies reported an association between the D allele and type 2 diabetes in Caucasian and East Asian populations. However, in mixed populations, such as those found in Brazil, such an association was not found. This fact does not discard the need for more studies on the frequencies of this polymorphism in the Brazilian population and the associations with risk factors, which can compromise the quality of life of diabetes patientsUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054-000, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054-000, SP, BrasilUniversidade Estadual Paulista (Unesp)Bonini-Domingos, Ana Carolina [UNESP]Bonini-Domingos, Claudia Regina [UNESP]Lacida, Edi Carlos [UNESP]Mattos, Cinara de Cássia Brandão deMattos, Luiz Carlos de2015-04-27T11:55:58Z2015-04-27T11:55:58Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article99-104http://www.sciencedirect.com/science/article/pii/S2214024714000574Biomarkers and Genomic Medicine, v. 6, p. 99-104, 2014.2214-0247http://hdl.handle.net/11449/12271210.1016/j.bgm.2014.06.00132794280661767190000-0002-4603-9467Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiomarkers and Genomic Medicine0,206info:eu-repo/semantics/openAccess2021-11-24T11:17:52Zoai:repositorio.unesp.br:11449/122712Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-11-24T11:17:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus |
title |
Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus |
spellingShingle |
Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus Bonini-Domingos, Ana Carolina [UNESP] ACE polymorphism angiotensin converting enzyme polymorphism genetic polymorphism I/D polymorphism type 2 diabet |
title_short |
Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus |
title_full |
Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus |
title_fullStr |
Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus |
title_full_unstemmed |
Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus |
title_sort |
Angiotensin converting enzyme polymorphism in type 2 diabetes mellitus |
author |
Bonini-Domingos, Ana Carolina [UNESP] |
author_facet |
Bonini-Domingos, Ana Carolina [UNESP] Bonini-Domingos, Claudia Regina [UNESP] Lacida, Edi Carlos [UNESP] Mattos, Cinara de Cássia Brandão de Mattos, Luiz Carlos de |
author_role |
author |
author2 |
Bonini-Domingos, Claudia Regina [UNESP] Lacida, Edi Carlos [UNESP] Mattos, Cinara de Cássia Brandão de Mattos, Luiz Carlos de |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Bonini-Domingos, Ana Carolina [UNESP] Bonini-Domingos, Claudia Regina [UNESP] Lacida, Edi Carlos [UNESP] Mattos, Cinara de Cássia Brandão de Mattos, Luiz Carlos de |
dc.subject.por.fl_str_mv |
ACE polymorphism angiotensin converting enzyme polymorphism genetic polymorphism I/D polymorphism type 2 diabet |
topic |
ACE polymorphism angiotensin converting enzyme polymorphism genetic polymorphism I/D polymorphism type 2 diabet |
description |
This study was undertaken to assess the frequency of angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism in patients with type 2 diabetes mellitus. A total of 162 patients with type 2 diabetes and 160 individuals without this disease were analyzed. From the diabetes group, 81 patients with cardiovascular risk (according to American Diabetes Association parameters) were selected to form another subgroup. For polymorphism identification, two polymerase chain reactions were performed: one reaction to identify all genotypes and a second one to confirm the presence of the I allele. The observed genotype frequencies were as follows: diabetes group I/I (19.1%), I/D (52.5%), D/D (28.4%); control group I/I (12.5%), I/D (55.6%), D/D (31.9%); and diabetes with cardiovascular risk group I/I (16.0%), I/ D (59.3%), D/D (24.7%). No statistically significant difference was observed between the allelic and genotypic frequencies in the analyzed groups. Previous studies reported an association between the D allele and type 2 diabetes in Caucasian and East Asian populations. However, in mixed populations, such as those found in Brazil, such an association was not found. This fact does not discard the need for more studies on the frequencies of this polymorphism in the Brazilian population and the associations with risk factors, which can compromise the quality of life of diabetes patients |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2015-04-27T11:55:58Z 2015-04-27T11:55:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sciencedirect.com/science/article/pii/S2214024714000574 Biomarkers and Genomic Medicine, v. 6, p. 99-104, 2014. 2214-0247 http://hdl.handle.net/11449/122712 10.1016/j.bgm.2014.06.001 3279428066176719 0000-0002-4603-9467 |
url |
http://www.sciencedirect.com/science/article/pii/S2214024714000574 http://hdl.handle.net/11449/122712 |
identifier_str_mv |
Biomarkers and Genomic Medicine, v. 6, p. 99-104, 2014. 2214-0247 10.1016/j.bgm.2014.06.001 3279428066176719 0000-0002-4603-9467 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biomarkers and Genomic Medicine 0,206 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
99-104 |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964885421916160 |