Long-term follow-up of patients with intestinal neuronal dysplasia type B
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1097/MD.0000000000007485 http://hdl.handle.net/11449/174965 |
Resumo: | Intestinal neuronal dysplasia type B (IND-B) is a pathological entity of the group of gastrointestinal neuromuscular diseases characterized by complex alterations in the enteric nervous system. Patients typically present with intestinal constipation, sometimes complicated by episodes of intestinal obstruction. The 2 therapeutic modalities include conservative clinical treatment and surgical treatment. Nevertheless, the results of the different therapeutic modalities are conflicting, and follow-up studies are scarce and include only a limited number of patients. This is a single-center, ambispective, observational, longitudinal, and comparative follow-up study to compare the results of conservative clinical and surgical treatments in patients with IND-B. Sixty-three patients (<15 years) who received this diagnosis will be included. These patients will be divided into 2 groups according to the type of treatment that they previously received: 29 patients in the surgical treatment group and 34 patients in the conservative treatment group. Previous data will be recovered from the medical records of the study patients, including signs and symptoms present at the time of diagnosis, particularly those related to bowel habits, and treatments undergone. Later, these patients will be invited to participate in a semistructured interview during which aspects related to the long-term functional results of the bowel habit and quality of life will be investigated after a minimum interval of 5 years posttreatment. This project aims to assess the long-term clinical evolution of patients diagnosed with IND-B and compare the results obtained following conservative clinical and surgical treatments. This protocol will provide sufficient data to analyze the long-term clinical outcome obtained through the 2 treatment modalities proposed for patients with IND-B. |
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Long-term follow-up of patients with intestinal neuronal dysplasia type Bintestinal chronic constipationintestinal dysganglionosisintestinal neuronal dysplasia type BIntestinal neuronal dysplasia type B (IND-B) is a pathological entity of the group of gastrointestinal neuromuscular diseases characterized by complex alterations in the enteric nervous system. Patients typically present with intestinal constipation, sometimes complicated by episodes of intestinal obstruction. The 2 therapeutic modalities include conservative clinical treatment and surgical treatment. Nevertheless, the results of the different therapeutic modalities are conflicting, and follow-up studies are scarce and include only a limited number of patients. This is a single-center, ambispective, observational, longitudinal, and comparative follow-up study to compare the results of conservative clinical and surgical treatments in patients with IND-B. Sixty-three patients (<15 years) who received this diagnosis will be included. These patients will be divided into 2 groups according to the type of treatment that they previously received: 29 patients in the surgical treatment group and 34 patients in the conservative treatment group. Previous data will be recovered from the medical records of the study patients, including signs and symptoms present at the time of diagnosis, particularly those related to bowel habits, and treatments undergone. Later, these patients will be invited to participate in a semistructured interview during which aspects related to the long-term functional results of the bowel habit and quality of life will be investigated after a minimum interval of 5 years posttreatment. This project aims to assess the long-term clinical evolution of patients diagnosed with IND-B and compare the results obtained following conservative clinical and surgical treatments. This protocol will provide sufficient data to analyze the long-term clinical outcome obtained through the 2 treatment modalities proposed for patients with IND-B.Discipline of Pediatric Surgery Department of Surgery and Orthopedics Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mario Rubens Guimaraes Montenegro, s/nBotucatu Medical School São Paulo State University (UNESP)Department of Pathology Botucatu Medical School São Paulo State University (UNESP)Discipline of Pediatric Surgery Department of Surgery and Orthopedics Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mario Rubens Guimaraes Montenegro, s/nBotucatu Medical School São Paulo State University (UNESP)Department of Pathology Botucatu Medical School São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)De Arruda Lourenção, Pedro Luiz Toledo [UNESP]Ortolan, Erika Veruska Paiva [UNESP]Rosa, Laura Luiza Minelli [UNESP]Angelini, Marcos Curcio [UNESP]Terra, Simone Antunes [UNESP]Rodrigues, Maria Aparecida Marchesan [UNESP]2018-12-11T17:13:39Z2018-12-11T17:13:39Z2017-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1097/MD.0000000000007485Medicine (United States), v. 96, n. 28, 2017.1536-59640025-7974http://hdl.handle.net/11449/17496510.1097/MD.00000000000074852-s2.0-850263153812-s2.0-85026315381.pdf920486536753246844285243055541240000-0002-8753-646X0000-0002-9697-3450Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedicine (United States)0,799info:eu-repo/semantics/openAccess2024-09-03T13:14:08Zoai:repositorio.unesp.br:11449/174965Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:08Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Long-term follow-up of patients with intestinal neuronal dysplasia type B |
title |
Long-term follow-up of patients with intestinal neuronal dysplasia type B |
spellingShingle |
Long-term follow-up of patients with intestinal neuronal dysplasia type B De Arruda Lourenção, Pedro Luiz Toledo [UNESP] intestinal chronic constipation intestinal dysganglionosis intestinal neuronal dysplasia type B |
title_short |
Long-term follow-up of patients with intestinal neuronal dysplasia type B |
title_full |
Long-term follow-up of patients with intestinal neuronal dysplasia type B |
title_fullStr |
Long-term follow-up of patients with intestinal neuronal dysplasia type B |
title_full_unstemmed |
Long-term follow-up of patients with intestinal neuronal dysplasia type B |
title_sort |
Long-term follow-up of patients with intestinal neuronal dysplasia type B |
author |
De Arruda Lourenção, Pedro Luiz Toledo [UNESP] |
author_facet |
De Arruda Lourenção, Pedro Luiz Toledo [UNESP] Ortolan, Erika Veruska Paiva [UNESP] Rosa, Laura Luiza Minelli [UNESP] Angelini, Marcos Curcio [UNESP] Terra, Simone Antunes [UNESP] Rodrigues, Maria Aparecida Marchesan [UNESP] |
author_role |
author |
author2 |
Ortolan, Erika Veruska Paiva [UNESP] Rosa, Laura Luiza Minelli [UNESP] Angelini, Marcos Curcio [UNESP] Terra, Simone Antunes [UNESP] Rodrigues, Maria Aparecida Marchesan [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
De Arruda Lourenção, Pedro Luiz Toledo [UNESP] Ortolan, Erika Veruska Paiva [UNESP] Rosa, Laura Luiza Minelli [UNESP] Angelini, Marcos Curcio [UNESP] Terra, Simone Antunes [UNESP] Rodrigues, Maria Aparecida Marchesan [UNESP] |
dc.subject.por.fl_str_mv |
intestinal chronic constipation intestinal dysganglionosis intestinal neuronal dysplasia type B |
topic |
intestinal chronic constipation intestinal dysganglionosis intestinal neuronal dysplasia type B |
description |
Intestinal neuronal dysplasia type B (IND-B) is a pathological entity of the group of gastrointestinal neuromuscular diseases characterized by complex alterations in the enteric nervous system. Patients typically present with intestinal constipation, sometimes complicated by episodes of intestinal obstruction. The 2 therapeutic modalities include conservative clinical treatment and surgical treatment. Nevertheless, the results of the different therapeutic modalities are conflicting, and follow-up studies are scarce and include only a limited number of patients. This is a single-center, ambispective, observational, longitudinal, and comparative follow-up study to compare the results of conservative clinical and surgical treatments in patients with IND-B. Sixty-three patients (<15 years) who received this diagnosis will be included. These patients will be divided into 2 groups according to the type of treatment that they previously received: 29 patients in the surgical treatment group and 34 patients in the conservative treatment group. Previous data will be recovered from the medical records of the study patients, including signs and symptoms present at the time of diagnosis, particularly those related to bowel habits, and treatments undergone. Later, these patients will be invited to participate in a semistructured interview during which aspects related to the long-term functional results of the bowel habit and quality of life will be investigated after a minimum interval of 5 years posttreatment. This project aims to assess the long-term clinical evolution of patients diagnosed with IND-B and compare the results obtained following conservative clinical and surgical treatments. This protocol will provide sufficient data to analyze the long-term clinical outcome obtained through the 2 treatment modalities proposed for patients with IND-B. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07-01 2018-12-11T17:13:39Z 2018-12-11T17:13:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1097/MD.0000000000007485 Medicine (United States), v. 96, n. 28, 2017. 1536-5964 0025-7974 http://hdl.handle.net/11449/174965 10.1097/MD.0000000000007485 2-s2.0-85026315381 2-s2.0-85026315381.pdf 9204865367532468 4428524305554124 0000-0002-8753-646X 0000-0002-9697-3450 |
url |
http://dx.doi.org/10.1097/MD.0000000000007485 http://hdl.handle.net/11449/174965 |
identifier_str_mv |
Medicine (United States), v. 96, n. 28, 2017. 1536-5964 0025-7974 10.1097/MD.0000000000007485 2-s2.0-85026315381 2-s2.0-85026315381.pdf 9204865367532468 4428524305554124 0000-0002-8753-646X 0000-0002-9697-3450 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medicine (United States) 0,799 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1810021355558535168 |