Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1089/pho.2016.4114 http://hdl.handle.net/11449/169412 |
Resumo: | Objective: In this study, we aim to compare the photodynamic inactivation (PDI) effects of two different photosensitizers (PS), Photogem® and Natural Curcumin, irradiated with light-emitted diodes (LED) at 630 and 450 nm, respectively. Background: The current antimicrobial mouthwash for oral hygiene has several drawbacks. In this context, PDI is an alternative technique to inactivate pathogenic microbes in mucosa and in periodontal tissue. Furthermore, there are numerous infectious diseases that may affect the oral cavity, motivating the use of PDI in dentistry. Methods: The volunteers (n = 50) were randomize separated into five experimental groups (n = 5) for each PS: water control, PS control, light control, and two PS concentrations (25 and 100 mg/L). Each patient underwent mouthwash solution containing the PS before illumination procedure that was performed with an LED device. For microbial decontamination evaluation, the saliva was collected three times: before (T0), immediately after (T1), and 24 h after the illumination procedure (T2). After that, the difference between the colony forming units (CFU) for each volunteer was compared. Results: The results show that regardless of PS and treatment applied, there was microbial reduction immediately after PDI, however, after 24 h only Natural Curcumin still presents a reduction. For Photogem after 24 h, the microorganism returns to the original CFU. Conclusions: Immediately after PDI, both PS have the same efficiency, nevertheless the Natural Curcumin still has an efficacy after 24 h and also is a more viable photosensitizer. In addition, the results indicate that PDI can be a promised technique used for microbial reducing for the oral cavity. |
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Repositório Institucional da UNESP |
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Clinical Comparison of Two Photosensitizers for Oral Cavity Decontaminationclinicalcurcuminoidshematoporphyrinin vivophotodynamic inactivationObjective: In this study, we aim to compare the photodynamic inactivation (PDI) effects of two different photosensitizers (PS), Photogem® and Natural Curcumin, irradiated with light-emitted diodes (LED) at 630 and 450 nm, respectively. Background: The current antimicrobial mouthwash for oral hygiene has several drawbacks. In this context, PDI is an alternative technique to inactivate pathogenic microbes in mucosa and in periodontal tissue. Furthermore, there are numerous infectious diseases that may affect the oral cavity, motivating the use of PDI in dentistry. Methods: The volunteers (n = 50) were randomize separated into five experimental groups (n = 5) for each PS: water control, PS control, light control, and two PS concentrations (25 and 100 mg/L). Each patient underwent mouthwash solution containing the PS before illumination procedure that was performed with an LED device. For microbial decontamination evaluation, the saliva was collected three times: before (T0), immediately after (T1), and 24 h after the illumination procedure (T2). After that, the difference between the colony forming units (CFU) for each volunteer was compared. Results: The results show that regardless of PS and treatment applied, there was microbial reduction immediately after PDI, however, after 24 h only Natural Curcumin still presents a reduction. For Photogem after 24 h, the microorganism returns to the original CFU. Conclusions: Immediately after PDI, both PS have the same efficiency, nevertheless the Natural Curcumin still has an efficacy after 24 h and also is a more viable photosensitizer. In addition, the results indicate that PDI can be a promised technique used for microbial reducing for the oral cavity.School of Dentistry of Araraquara UNESP University of Estadual PaulistaSão Carlos Institute of Physics University of São Paulo, PO Box 369Biomedical Engineer Research Center CEB Camilo Castelo Branco UniversitySchool of Dentistry of Araraquara UNESP University of Estadual PaulistaUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Camilo Castelo Branco UniversityDonato, Hérica Adad Ricci [UNESP]Pratavieira, SebastiãoGrecco, ClovisBrugnera-Júnior, AldoBagnato, Vanderlei SalvadorKurachi, Cristina2018-12-11T16:45:46Z2018-12-11T16:45:46Z2017-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article105-110application/pdfhttp://dx.doi.org/10.1089/pho.2016.4114Photomedicine and Laser Surgery, v. 35, n. 2, p. 105-110, 2017.1549-5418http://hdl.handle.net/11449/16941210.1089/pho.2016.41142-s2.0-850110200432-s2.0-85011020043.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhotomedicine and Laser Surgery0,443info:eu-repo/semantics/openAccess2023-10-18T06:04:55Zoai:repositorio.unesp.br:11449/169412Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-18T06:04:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination |
title |
Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination |
spellingShingle |
Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination Donato, Hérica Adad Ricci [UNESP] clinical curcuminoids hematoporphyrin in vivo photodynamic inactivation |
title_short |
Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination |
title_full |
Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination |
title_fullStr |
Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination |
title_full_unstemmed |
Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination |
title_sort |
Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination |
author |
Donato, Hérica Adad Ricci [UNESP] |
author_facet |
Donato, Hérica Adad Ricci [UNESP] Pratavieira, Sebastião Grecco, Clovis Brugnera-Júnior, Aldo Bagnato, Vanderlei Salvador Kurachi, Cristina |
author_role |
author |
author2 |
Pratavieira, Sebastião Grecco, Clovis Brugnera-Júnior, Aldo Bagnato, Vanderlei Salvador Kurachi, Cristina |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Camilo Castelo Branco University |
dc.contributor.author.fl_str_mv |
Donato, Hérica Adad Ricci [UNESP] Pratavieira, Sebastião Grecco, Clovis Brugnera-Júnior, Aldo Bagnato, Vanderlei Salvador Kurachi, Cristina |
dc.subject.por.fl_str_mv |
clinical curcuminoids hematoporphyrin in vivo photodynamic inactivation |
topic |
clinical curcuminoids hematoporphyrin in vivo photodynamic inactivation |
description |
Objective: In this study, we aim to compare the photodynamic inactivation (PDI) effects of two different photosensitizers (PS), Photogem® and Natural Curcumin, irradiated with light-emitted diodes (LED) at 630 and 450 nm, respectively. Background: The current antimicrobial mouthwash for oral hygiene has several drawbacks. In this context, PDI is an alternative technique to inactivate pathogenic microbes in mucosa and in periodontal tissue. Furthermore, there are numerous infectious diseases that may affect the oral cavity, motivating the use of PDI in dentistry. Methods: The volunteers (n = 50) were randomize separated into five experimental groups (n = 5) for each PS: water control, PS control, light control, and two PS concentrations (25 and 100 mg/L). Each patient underwent mouthwash solution containing the PS before illumination procedure that was performed with an LED device. For microbial decontamination evaluation, the saliva was collected three times: before (T0), immediately after (T1), and 24 h after the illumination procedure (T2). After that, the difference between the colony forming units (CFU) for each volunteer was compared. Results: The results show that regardless of PS and treatment applied, there was microbial reduction immediately after PDI, however, after 24 h only Natural Curcumin still presents a reduction. For Photogem after 24 h, the microorganism returns to the original CFU. Conclusions: Immediately after PDI, both PS have the same efficiency, nevertheless the Natural Curcumin still has an efficacy after 24 h and also is a more viable photosensitizer. In addition, the results indicate that PDI can be a promised technique used for microbial reducing for the oral cavity. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02-01 2018-12-11T16:45:46Z 2018-12-11T16:45:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1089/pho.2016.4114 Photomedicine and Laser Surgery, v. 35, n. 2, p. 105-110, 2017. 1549-5418 http://hdl.handle.net/11449/169412 10.1089/pho.2016.4114 2-s2.0-85011020043 2-s2.0-85011020043.pdf |
url |
http://dx.doi.org/10.1089/pho.2016.4114 http://hdl.handle.net/11449/169412 |
identifier_str_mv |
Photomedicine and Laser Surgery, v. 35, n. 2, p. 105-110, 2017. 1549-5418 10.1089/pho.2016.4114 2-s2.0-85011020043 2-s2.0-85011020043.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Photomedicine and Laser Surgery 0,443 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
105-110 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964604130918400 |