Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.lfs.2010.11.018 http://hdl.handle.net/11449/72300 |
Resumo: | Aims: The effect of exercise training (ET) on vascular responsiveness in diabetes mellitus has been largely well studied. However, limited studies have investigated the effects of ET on functional responses of the corpus cavernosum (CC) in diabetic animals. Therefore, the aim of this study was to investigate whether prior ET prevents the impairment of erectile function in streptozotocin-induced diabetic rats. Main methods: Rats were exercised for four weeks prior to the induction of diabetes, and then again for another 4 weeks thereafter. Concentration-response curves to acetylcholine, sodium nitroprusside, Y-27632, BAY 412272 and phenylephrine (PE) were obtained in CC. The excitatory and inhibitory effects of electrical-field stimulation were also evaluated. Key findings: Plasma SOD levels were markedly decreased in the sedentary diabetic group (D-SD) as compared to control sedentary animals (C-SD), approximately 53% (P < 0.05) and this reduction was restored in trained diabetic animals. Physical training restored the impairment of endothelium-dependent and -independent relaxation responses seen in the D-SD group. The potency values for Y-27632 in the CC were significantly reduced in the D-SD group, which was reversed by physical training. The impairment of electrical-field stimulation (EFS)-induced relaxation seen in the D-SD group was restored by physical training. On the other hand, both EFS-induced contractions and concentration-response curves to PE in cavernosal strips were not modified by either diabetes or physical training. Significance: Practice of regular physical exercise may be an important approach in preventing erectile dysfunction associated with diabetes mellitus by re-establishment of the balance between NO production and its inactivation. © 2010 Elsevier Inc. All rights reserved. |
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Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic ratsCorpus cavernosumDiabetesPhysical trainingSuperoxide dismutase4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide4 amino 5 cyclopropyl 2 [1 (2 fluorobenzyl) 1h pyrazolo[3,4 b]pyridin 3 yl]pyrimidineacetylcholinenitric oxidenitroprusside sodiumphenylephrinesuperoxide dismutaseanimal experimentanimal modelanimal tissueblood vessel reactivitycontrolled studycorpus cavernosumdiabetes mellituselectrostimulationerectile dysfunctionexercisemalenitrergic nervenonhumanratsmooth muscle relaxationstreptozocin diabetesvascular endotheliumAnimalsCells, CulturedDiabetes Mellitus, ExperimentalErectile DysfunctionMaleMuscle ContractionMuscle, SmoothPenile ErectionPhysical Conditioning, AnimalRatsAnimaliaRattusAims: The effect of exercise training (ET) on vascular responsiveness in diabetes mellitus has been largely well studied. However, limited studies have investigated the effects of ET on functional responses of the corpus cavernosum (CC) in diabetic animals. Therefore, the aim of this study was to investigate whether prior ET prevents the impairment of erectile function in streptozotocin-induced diabetic rats. Main methods: Rats were exercised for four weeks prior to the induction of diabetes, and then again for another 4 weeks thereafter. Concentration-response curves to acetylcholine, sodium nitroprusside, Y-27632, BAY 412272 and phenylephrine (PE) were obtained in CC. The excitatory and inhibitory effects of electrical-field stimulation were also evaluated. Key findings: Plasma SOD levels were markedly decreased in the sedentary diabetic group (D-SD) as compared to control sedentary animals (C-SD), approximately 53% (P < 0.05) and this reduction was restored in trained diabetic animals. Physical training restored the impairment of endothelium-dependent and -independent relaxation responses seen in the D-SD group. The potency values for Y-27632 in the CC were significantly reduced in the D-SD group, which was reversed by physical training. The impairment of electrical-field stimulation (EFS)-induced relaxation seen in the D-SD group was restored by physical training. On the other hand, both EFS-induced contractions and concentration-response curves to PE in cavernosal strips were not modified by either diabetes or physical training. Significance: Practice of regular physical exercise may be an important approach in preventing erectile dysfunction associated with diabetes mellitus by re-establishment of the balance between NO production and its inactivation. © 2010 Elsevier Inc. All rights reserved.Department of Pharmacology Faculty of Medical Sciences University of Campinas (UNICAMP), Campinas (SP)Department of Physical Education Institute of Bioscience UNESP, 13506-900 Rio Claro (SP)Hematology and Hemotherapy Center Faculty of Medical Sciences University of Campinas (UNICAMP), PO Box 6111, 13084-971, Campinas (SP)Department of Physical Education Institute of Bioscience UNESP, 13506-900 Rio Claro (SP)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Claudino, Mario A.Delbin, Maria A. [UNESP]Franco-Penteado, Carla F.Priviero, Fernanda B. [UNESP]De Nucci, GilbertoAntunes, EdsonZanesco, Angelina [UNESP]2014-05-27T11:25:27Z2014-05-27T11:25:27Z2011-01-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article272-277application/pdfhttp://dx.doi.org/10.1016/j.lfs.2010.11.018Life Sciences, v. 88, n. 5-6, p. 272-277, 2011.0024-3205http://hdl.handle.net/11449/7230010.1016/j.lfs.2010.11.0182-s2.0-787516470732-s2.0-78751647073.pdf4472007237545596Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciences3.2341,071info:eu-repo/semantics/openAccess2023-10-04T06:09:23Zoai:repositorio.unesp.br:11449/72300Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-05-23T11:30:21.722303Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats |
title |
Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats |
spellingShingle |
Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats Claudino, Mario A. Corpus cavernosum Diabetes Physical training Superoxide dismutase 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide 4 amino 5 cyclopropyl 2 [1 (2 fluorobenzyl) 1h pyrazolo[3,4 b]pyridin 3 yl]pyrimidine acetylcholine nitric oxide nitroprusside sodium phenylephrine superoxide dismutase animal experiment animal model animal tissue blood vessel reactivity controlled study corpus cavernosum diabetes mellitus electrostimulation erectile dysfunction exercise male nitrergic nerve nonhuman rat smooth muscle relaxation streptozocin diabetes vascular endothelium Animals Cells, Cultured Diabetes Mellitus, Experimental Erectile Dysfunction Male Muscle Contraction Muscle, Smooth Penile Erection Physical Conditioning, Animal Rats Animalia Rattus |
title_short |
Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats |
title_full |
Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats |
title_fullStr |
Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats |
title_full_unstemmed |
Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats |
title_sort |
Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats |
author |
Claudino, Mario A. |
author_facet |
Claudino, Mario A. Delbin, Maria A. [UNESP] Franco-Penteado, Carla F. Priviero, Fernanda B. [UNESP] De Nucci, Gilberto Antunes, Edson Zanesco, Angelina [UNESP] |
author_role |
author |
author2 |
Delbin, Maria A. [UNESP] Franco-Penteado, Carla F. Priviero, Fernanda B. [UNESP] De Nucci, Gilberto Antunes, Edson Zanesco, Angelina [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Claudino, Mario A. Delbin, Maria A. [UNESP] Franco-Penteado, Carla F. Priviero, Fernanda B. [UNESP] De Nucci, Gilberto Antunes, Edson Zanesco, Angelina [UNESP] |
dc.subject.por.fl_str_mv |
Corpus cavernosum Diabetes Physical training Superoxide dismutase 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide 4 amino 5 cyclopropyl 2 [1 (2 fluorobenzyl) 1h pyrazolo[3,4 b]pyridin 3 yl]pyrimidine acetylcholine nitric oxide nitroprusside sodium phenylephrine superoxide dismutase animal experiment animal model animal tissue blood vessel reactivity controlled study corpus cavernosum diabetes mellitus electrostimulation erectile dysfunction exercise male nitrergic nerve nonhuman rat smooth muscle relaxation streptozocin diabetes vascular endothelium Animals Cells, Cultured Diabetes Mellitus, Experimental Erectile Dysfunction Male Muscle Contraction Muscle, Smooth Penile Erection Physical Conditioning, Animal Rats Animalia Rattus |
topic |
Corpus cavernosum Diabetes Physical training Superoxide dismutase 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide 4 amino 5 cyclopropyl 2 [1 (2 fluorobenzyl) 1h pyrazolo[3,4 b]pyridin 3 yl]pyrimidine acetylcholine nitric oxide nitroprusside sodium phenylephrine superoxide dismutase animal experiment animal model animal tissue blood vessel reactivity controlled study corpus cavernosum diabetes mellitus electrostimulation erectile dysfunction exercise male nitrergic nerve nonhuman rat smooth muscle relaxation streptozocin diabetes vascular endothelium Animals Cells, Cultured Diabetes Mellitus, Experimental Erectile Dysfunction Male Muscle Contraction Muscle, Smooth Penile Erection Physical Conditioning, Animal Rats Animalia Rattus |
description |
Aims: The effect of exercise training (ET) on vascular responsiveness in diabetes mellitus has been largely well studied. However, limited studies have investigated the effects of ET on functional responses of the corpus cavernosum (CC) in diabetic animals. Therefore, the aim of this study was to investigate whether prior ET prevents the impairment of erectile function in streptozotocin-induced diabetic rats. Main methods: Rats were exercised for four weeks prior to the induction of diabetes, and then again for another 4 weeks thereafter. Concentration-response curves to acetylcholine, sodium nitroprusside, Y-27632, BAY 412272 and phenylephrine (PE) were obtained in CC. The excitatory and inhibitory effects of electrical-field stimulation were also evaluated. Key findings: Plasma SOD levels were markedly decreased in the sedentary diabetic group (D-SD) as compared to control sedentary animals (C-SD), approximately 53% (P < 0.05) and this reduction was restored in trained diabetic animals. Physical training restored the impairment of endothelium-dependent and -independent relaxation responses seen in the D-SD group. The potency values for Y-27632 in the CC were significantly reduced in the D-SD group, which was reversed by physical training. The impairment of electrical-field stimulation (EFS)-induced relaxation seen in the D-SD group was restored by physical training. On the other hand, both EFS-induced contractions and concentration-response curves to PE in cavernosal strips were not modified by either diabetes or physical training. Significance: Practice of regular physical exercise may be an important approach in preventing erectile dysfunction associated with diabetes mellitus by re-establishment of the balance between NO production and its inactivation. © 2010 Elsevier Inc. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-31 2014-05-27T11:25:27Z 2014-05-27T11:25:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.lfs.2010.11.018 Life Sciences, v. 88, n. 5-6, p. 272-277, 2011. 0024-3205 http://hdl.handle.net/11449/72300 10.1016/j.lfs.2010.11.018 2-s2.0-78751647073 2-s2.0-78751647073.pdf 4472007237545596 |
url |
http://dx.doi.org/10.1016/j.lfs.2010.11.018 http://hdl.handle.net/11449/72300 |
identifier_str_mv |
Life Sciences, v. 88, n. 5-6, p. 272-277, 2011. 0024-3205 10.1016/j.lfs.2010.11.018 2-s2.0-78751647073 2-s2.0-78751647073.pdf 4472007237545596 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life Sciences 3.234 1,071 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
272-277 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045834917412864 |