CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series report

Detalhes bibliográficos
Autor(a) principal: Firmo, Bruna Fernanda [UNESP]
Data de Publicação: 2014
Outros Autores: Grandi, Fabrizio [UNESP], Cogliati, Bruno, Rocha, Noeme Sousa [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.researchsource.org/journals/getarchivedata/10/13/login
http://hdl.handle.net/11449/140544
Resumo: Back ground: Basal cell carcinomas and follicular tumors are relatively common skin neoplasms both in veterinary and human medicine. Currently, it is believed that stem cells are important for skin tumor development. Hypothesis/objective: the objective of the study was to characterize CD34 expression in canine follicular tumors and basal cell carcinoma in order to investigate the possible role of these cells in skin tumorigenesis. Animals & Methods: eleven skin tumors including basal cell carcinomas and follicular tumors were submitted to immunohistochemistry using the stem cell marker CD34. Results: CD34 labelling was characterized by a fine, granular and diffuses brown cytoplasmic staining both in control (endothelial cells) and neoplastic cells. Two BCC and one trichoepithelioma displayed positive neoplastic cells and/or fibroblast-like stromal cells. Conclusion: preliminary results described here should be confirmed by large scale studies in order to clarify the potential role of stem cells on human and canine skin tumors.
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spelling CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series reportMammary carcinomaDiagnosisHistopathologyDogBack ground: Basal cell carcinomas and follicular tumors are relatively common skin neoplasms both in veterinary and human medicine. Currently, it is believed that stem cells are important for skin tumor development. Hypothesis/objective: the objective of the study was to characterize CD34 expression in canine follicular tumors and basal cell carcinoma in order to investigate the possible role of these cells in skin tumorigenesis. Animals & Methods: eleven skin tumors including basal cell carcinomas and follicular tumors were submitted to immunohistochemistry using the stem cell marker CD34. Results: CD34 labelling was characterized by a fine, granular and diffuses brown cytoplasmic staining both in control (endothelial cells) and neoplastic cells. Two BCC and one trichoepithelioma displayed positive neoplastic cells and/or fibroblast-like stromal cells. Conclusion: preliminary results described here should be confirmed by large scale studies in order to clarify the potential role of stem cells on human and canine skin tumors.Laboratory of Investigative and Comparative Pathology, School of Veterinary Medicine and Animal Science, Univ Estadual Paulista – UNESP, Botucatu, BrazilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Veterinária, Faculdade de Medicina Veterinária e Zootecnia de Botucatu, Botucatu, AC Rubião Junior, Jardim Santo Inácio (Rubião Junior), CEP 18618970, SP, BrasilDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, SP, BrazilLaboratory of Investigative and Comparative Pathology, School of Veterinary Medicine and Animal Science, Univ Estadual Paulista – UNESP, Botucatu, BrazilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Veterinária, Faculdade de Medicina Veterinária e Zootecnia de Botucatu, Botucatu, AC Rubião Junior, Jardim Santo Inácio (Rubião Junior), CEP 18618970, SP, BrasilUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Firmo, Bruna Fernanda [UNESP]Grandi, Fabrizio [UNESP]Cogliati, BrunoRocha, Noeme Sousa [UNESP]2016-07-07T12:34:21Z2016-07-07T12:34:21Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-4application/pdfhttp://www.researchsource.org/journals/getarchivedata/10/13/loginSource Journal of Veterinary Science, v. 1, n. 1, p. 1-4, 2014.2374-6327http://hdl.handle.net/11449/140544ISSN2374-6327-2014-01-01-01-04.pdf60777359184692840000-0002-8188-8149Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSource Journal of Veterinary Scienceinfo:eu-repo/semantics/openAccess2024-09-03T13:17:49Zoai:repositorio.unesp.br:11449/140544Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:17:49Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series report
title CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series report
spellingShingle CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series report
Firmo, Bruna Fernanda [UNESP]
Mammary carcinoma
Diagnosis
Histopathology
Dog
title_short CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series report
title_full CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series report
title_fullStr CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series report
title_full_unstemmed CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series report
title_sort CD34 immunoexpression in canine skin follicular tumors and basal cell carcinomas: case series report
author Firmo, Bruna Fernanda [UNESP]
author_facet Firmo, Bruna Fernanda [UNESP]
Grandi, Fabrizio [UNESP]
Cogliati, Bruno
Rocha, Noeme Sousa [UNESP]
author_role author
author2 Grandi, Fabrizio [UNESP]
Cogliati, Bruno
Rocha, Noeme Sousa [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Firmo, Bruna Fernanda [UNESP]
Grandi, Fabrizio [UNESP]
Cogliati, Bruno
Rocha, Noeme Sousa [UNESP]
dc.subject.por.fl_str_mv Mammary carcinoma
Diagnosis
Histopathology
Dog
topic Mammary carcinoma
Diagnosis
Histopathology
Dog
description Back ground: Basal cell carcinomas and follicular tumors are relatively common skin neoplasms both in veterinary and human medicine. Currently, it is believed that stem cells are important for skin tumor development. Hypothesis/objective: the objective of the study was to characterize CD34 expression in canine follicular tumors and basal cell carcinoma in order to investigate the possible role of these cells in skin tumorigenesis. Animals & Methods: eleven skin tumors including basal cell carcinomas and follicular tumors were submitted to immunohistochemistry using the stem cell marker CD34. Results: CD34 labelling was characterized by a fine, granular and diffuses brown cytoplasmic staining both in control (endothelial cells) and neoplastic cells. Two BCC and one trichoepithelioma displayed positive neoplastic cells and/or fibroblast-like stromal cells. Conclusion: preliminary results described here should be confirmed by large scale studies in order to clarify the potential role of stem cells on human and canine skin tumors.
publishDate 2014
dc.date.none.fl_str_mv 2014
2016-07-07T12:34:21Z
2016-07-07T12:34:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.researchsource.org/journals/getarchivedata/10/13/login
Source Journal of Veterinary Science, v. 1, n. 1, p. 1-4, 2014.
2374-6327
http://hdl.handle.net/11449/140544
ISSN2374-6327-2014-01-01-01-04.pdf
6077735918469284
0000-0002-8188-8149
url http://www.researchsource.org/journals/getarchivedata/10/13/login
http://hdl.handle.net/11449/140544
identifier_str_mv Source Journal of Veterinary Science, v. 1, n. 1, p. 1-4, 2014.
2374-6327
ISSN2374-6327-2014-01-01-01-04.pdf
6077735918469284
0000-0002-8188-8149
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Source Journal of Veterinary Science
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-4
application/pdf
dc.source.none.fl_str_mv Currículo Lattes
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1810021397940928512

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