Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/nu10081122 http://hdl.handle.net/11449/184872 |
Resumo: | Background: Epigallocatechin 3 Gallate (EGCG) appears to act in appetite control through hormonal modulation. However, there is a lack of elucidation of EGCG's action mechanisms, especially in humans. The aim of this study was to evaluate the effects of acute EGCG supplementation on gastric emptying and its relation to blood hormones, glucose and appetite perceptions in healthy women. Methods: 22 healthy adult women were included in a randomized, double-blind, placebo-controlled crossover study. On two separate occasions, 1 week apart from each other, we offered 800 mg of corn starch (placebo) or 752 mg of EGCG. Appetite was assessed through gastric emptying; perceptions of hunger, desire to eat and satiation; and plasma insulin, adiponectin, leptin and glucose concentrations. The evaluations were carried out in fasting, 30, 90 and 150 min after supplementation. Results: EGCG supplementation induced higher relative gastric volume at 30 and 90 min. Satiation at 90 min was higher in the EGCG group. Adiponectin concentrations at 150 min were higher with EGCG, but no difference was found for glucose, insulin and leptin concentrations. Conclusions: Acute EGCG supplementation is able to delay gastric emptying in healthy women to a small, but statistically significant extent. This study was registered at the Brazilian Registry of Clinical Trials (ReBEC) as RBR-9svwrv. |
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Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover StudyCamellia sinensisEGCGcatechingastric emptyingsatiety responsesatiationBackground: Epigallocatechin 3 Gallate (EGCG) appears to act in appetite control through hormonal modulation. However, there is a lack of elucidation of EGCG's action mechanisms, especially in humans. The aim of this study was to evaluate the effects of acute EGCG supplementation on gastric emptying and its relation to blood hormones, glucose and appetite perceptions in healthy women. Methods: 22 healthy adult women were included in a randomized, double-blind, placebo-controlled crossover study. On two separate occasions, 1 week apart from each other, we offered 800 mg of corn starch (placebo) or 752 mg of EGCG. Appetite was assessed through gastric emptying; perceptions of hunger, desire to eat and satiation; and plasma insulin, adiponectin, leptin and glucose concentrations. The evaluations were carried out in fasting, 30, 90 and 150 min after supplementation. Results: EGCG supplementation induced higher relative gastric volume at 30 and 90 min. Satiation at 90 min was higher in the EGCG group. Adiponectin concentrations at 150 min were higher with EGCG, but no difference was found for glucose, insulin and leptin concentrations. Conclusions: Acute EGCG supplementation is able to delay gastric emptying in healthy women to a small, but statistically significant extent. This study was registered at the Brazilian Registry of Clinical Trials (ReBEC) as RBR-9svwrv.FAPEG, GO, BrazilUniv Fed Goias, Fac Nutr, Clin & Sports Nutr Res Lab Labince, BR-74605080 Goiania, Go, BrazilUniv Fed Goias, Med Univ, Dept Radiol & Diagnost Imaging, BR-74605050 Goiania, Go, BrazilUniv Estadual Paulista, Dept Phys Educ, Exercise & Immunometab Res Grp, BR-19060900 Sao Paulo, BrazilUniv Estadual Paulista, Dept Phys Educ, Exercise & Immunometab Res Grp, BR-19060900 Sao Paulo, BrazilMdpiUniversidade Federal de Goiás (UFG)Universidade Estadual Paulista (Unesp)Fernandes, Renata C.Araujo, Vanessa A.Giglio, Bruna M.Marini, Ana Clara B.Mota, Joao F.Teixeira, Kim-Ir-Sen S.Monteiro, Paula A. [UNESP]Lira, Fabio S. [UNESP]Pimentel, Gustavo D.2019-10-04T12:30:41Z2019-10-04T12:30:41Z2018-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13http://dx.doi.org/10.3390/nu10081122Nutrients. Basel: Mdpi, v. 10, n. 8, 13 p., 2018.2072-6643http://hdl.handle.net/11449/18487210.3390/nu10081122WOS:000445680200170Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNutrientsinfo:eu-repo/semantics/openAccess2024-06-18T17:42:59Zoai:repositorio.unesp.br:11449/184872Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:25:25.303669Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study |
title |
Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study |
spellingShingle |
Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study Fernandes, Renata C. Camellia sinensis EGCG catechin gastric emptying satiety response satiation |
title_short |
Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study |
title_full |
Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study |
title_fullStr |
Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study |
title_full_unstemmed |
Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study |
title_sort |
Acute Epigallocatechin 3 Gallate (EGCG) Supplementation Delays Gastric Emptying in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Crossover Study |
author |
Fernandes, Renata C. |
author_facet |
Fernandes, Renata C. Araujo, Vanessa A. Giglio, Bruna M. Marini, Ana Clara B. Mota, Joao F. Teixeira, Kim-Ir-Sen S. Monteiro, Paula A. [UNESP] Lira, Fabio S. [UNESP] Pimentel, Gustavo D. |
author_role |
author |
author2 |
Araujo, Vanessa A. Giglio, Bruna M. Marini, Ana Clara B. Mota, Joao F. Teixeira, Kim-Ir-Sen S. Monteiro, Paula A. [UNESP] Lira, Fabio S. [UNESP] Pimentel, Gustavo D. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Goiás (UFG) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Fernandes, Renata C. Araujo, Vanessa A. Giglio, Bruna M. Marini, Ana Clara B. Mota, Joao F. Teixeira, Kim-Ir-Sen S. Monteiro, Paula A. [UNESP] Lira, Fabio S. [UNESP] Pimentel, Gustavo D. |
dc.subject.por.fl_str_mv |
Camellia sinensis EGCG catechin gastric emptying satiety response satiation |
topic |
Camellia sinensis EGCG catechin gastric emptying satiety response satiation |
description |
Background: Epigallocatechin 3 Gallate (EGCG) appears to act in appetite control through hormonal modulation. However, there is a lack of elucidation of EGCG's action mechanisms, especially in humans. The aim of this study was to evaluate the effects of acute EGCG supplementation on gastric emptying and its relation to blood hormones, glucose and appetite perceptions in healthy women. Methods: 22 healthy adult women were included in a randomized, double-blind, placebo-controlled crossover study. On two separate occasions, 1 week apart from each other, we offered 800 mg of corn starch (placebo) or 752 mg of EGCG. Appetite was assessed through gastric emptying; perceptions of hunger, desire to eat and satiation; and plasma insulin, adiponectin, leptin and glucose concentrations. The evaluations were carried out in fasting, 30, 90 and 150 min after supplementation. Results: EGCG supplementation induced higher relative gastric volume at 30 and 90 min. Satiation at 90 min was higher in the EGCG group. Adiponectin concentrations at 150 min were higher with EGCG, but no difference was found for glucose, insulin and leptin concentrations. Conclusions: Acute EGCG supplementation is able to delay gastric emptying in healthy women to a small, but statistically significant extent. This study was registered at the Brazilian Registry of Clinical Trials (ReBEC) as RBR-9svwrv. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-01 2019-10-04T12:30:41Z 2019-10-04T12:30:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/nu10081122 Nutrients. Basel: Mdpi, v. 10, n. 8, 13 p., 2018. 2072-6643 http://hdl.handle.net/11449/184872 10.3390/nu10081122 WOS:000445680200170 |
url |
http://dx.doi.org/10.3390/nu10081122 http://hdl.handle.net/11449/184872 |
identifier_str_mv |
Nutrients. Basel: Mdpi, v. 10, n. 8, 13 p., 2018. 2072-6643 10.3390/nu10081122 WOS:000445680200170 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutrients |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
13 |
dc.publisher.none.fl_str_mv |
Mdpi |
publisher.none.fl_str_mv |
Mdpi |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129065140355072 |