Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs

Detalhes bibliográficos
Autor(a) principal: De Amorim Cerejo, Sofia
Data de Publicação: 2013
Outros Autores: De Mattos Jr., Ewaldo, Nishimura, Lilian Toshiko, Quarterone, Carolina [UNESP], Franco, Leandro Guimarães
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5433/1679-0359.2013v34n4p1807
http://hdl.handle.net/11449/75874
Resumo: Constant rate infusion (CRI) shows several advantages in balanced anesthesia, such as reduction of requirement for inhaled anesthetics and control of pain. The most commonly used drugs in these protocols are local anesthetics, dissociative, and opioids, which may be administered alone or in combinations. We evaluated the records of 200 dogs that underwent various surgical procedures with anesthetic or analgesic CRI in the perioperative period during 2011 and 2012 at the Veterinary Hospital of Franca University (Unifran), and identified possible complications during the transoperative period. Records evaluated included clinical state, laboratory tests, drugs used in premedication and induction, and CRI protocol. Acepromazine and morphine were the main drugs used in premedication. Propofol was used to induce anesthesia alone or in combination with other agents. We evaluated records of the 25 different CRI protocols. Fentanyl was the main drug employed in CRI, either alone or in combination. There were 128 episodes of anesthetic complications during CRI;the most common were hypotension, hypertension, and tachycardia, which occurred in 43 (32%), 35 (26.3%), and 19 (14.2%) dogs, respectively. Cardiac arrhythmia was reported in only 4 dogs. Signs of respiratory depression were present in dogs treated with 6 different CRI protocols. The consumption of isoflurane (vol %) reduced between 15.7% and 21.05% after 30minutes of the CRI in the fentanyl and fentanyl-lidocaine-ketamine CRI groups (p<0.05). In conclusion, CRI is a valid component of balanced anesthesia in dogs, safe, and has a low incidence of adverse effects. However, future studies are warranted to describe the results of the clinical use of CRI to better characterize and refine this technique.
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spelling Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogsContinuous intravenous infusionFentanylKetamineLidocaineMorphineConstant rate infusion (CRI) shows several advantages in balanced anesthesia, such as reduction of requirement for inhaled anesthetics and control of pain. The most commonly used drugs in these protocols are local anesthetics, dissociative, and opioids, which may be administered alone or in combinations. We evaluated the records of 200 dogs that underwent various surgical procedures with anesthetic or analgesic CRI in the perioperative period during 2011 and 2012 at the Veterinary Hospital of Franca University (Unifran), and identified possible complications during the transoperative period. Records evaluated included clinical state, laboratory tests, drugs used in premedication and induction, and CRI protocol. Acepromazine and morphine were the main drugs used in premedication. Propofol was used to induce anesthesia alone or in combination with other agents. We evaluated records of the 25 different CRI protocols. Fentanyl was the main drug employed in CRI, either alone or in combination. There were 128 episodes of anesthetic complications during CRI;the most common were hypotension, hypertension, and tachycardia, which occurred in 43 (32%), 35 (26.3%), and 19 (14.2%) dogs, respectively. Cardiac arrhythmia was reported in only 4 dogs. Signs of respiratory depression were present in dogs treated with 6 different CRI protocols. The consumption of isoflurane (vol %) reduced between 15.7% and 21.05% after 30minutes of the CRI in the fentanyl and fentanyl-lidocaine-ketamine CRI groups (p<0.05). In conclusion, CRI is a valid component of balanced anesthesia in dogs, safe, and has a low incidence of adverse effects. However, future studies are warranted to describe the results of the clinical use of CRI to better characterize and refine this technique.Universidade de Franca UNIFRAN, Franca, SPUniversidade Estadual Paulista Júlio de Mesquita Filho Campus Botucatu UNESP, Botucatu, SPUniversidade Estadual de Santa Cruz UESC, Ilhéus, BAUniversidade Estadual Paulista Júlio de Mesquita Filho Campus Botucatu UNESP, Botucatu, SPUNIFRANUniversidade Estadual Paulista (Unesp)Universidade Estadual de Santa Cruz (UESC)De Amorim Cerejo, SofiaDe Mattos Jr., EwaldoNishimura, Lilian ToshikoQuarterone, Carolina [UNESP]Franco, Leandro Guimarães2014-05-27T11:29:54Z2014-05-27T11:29:54Z2013-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1807-1822application/pdfhttp://dx.doi.org/10.5433/1679-0359.2013v34n4p1807Semina:Ciencias Agrarias, v. 34, n. 4, p. 1807-1822, 2013.1676-546X1679-0359http://hdl.handle.net/11449/7587410.5433/1679-0359.2013v34n4p1807WOS:0003282699000332-s2.0-848851175122-s2.0-84885117512.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSemina: Ciências Agrárias0.3490,320info:eu-repo/semantics/openAccess2023-12-07T06:21:35Zoai:repositorio.unesp.br:11449/75874Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:44:34.552497Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs
title Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs
spellingShingle Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs
De Amorim Cerejo, Sofia
Continuous intravenous infusion
Fentanyl
Ketamine
Lidocaine
Morphine
title_short Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs
title_full Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs
title_fullStr Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs
title_full_unstemmed Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs
title_sort Effects of constant rate infusion of anesthetic or analgesic drugs on general anesthesia with isoflurane: A retrospective study in 200 dogs
author De Amorim Cerejo, Sofia
author_facet De Amorim Cerejo, Sofia
De Mattos Jr., Ewaldo
Nishimura, Lilian Toshiko
Quarterone, Carolina [UNESP]
Franco, Leandro Guimarães
author_role author
author2 De Mattos Jr., Ewaldo
Nishimura, Lilian Toshiko
Quarterone, Carolina [UNESP]
Franco, Leandro Guimarães
author2_role author
author
author
author
dc.contributor.none.fl_str_mv UNIFRAN
Universidade Estadual Paulista (Unesp)
Universidade Estadual de Santa Cruz (UESC)
dc.contributor.author.fl_str_mv De Amorim Cerejo, Sofia
De Mattos Jr., Ewaldo
Nishimura, Lilian Toshiko
Quarterone, Carolina [UNESP]
Franco, Leandro Guimarães
dc.subject.por.fl_str_mv Continuous intravenous infusion
Fentanyl
Ketamine
Lidocaine
Morphine
topic Continuous intravenous infusion
Fentanyl
Ketamine
Lidocaine
Morphine
description Constant rate infusion (CRI) shows several advantages in balanced anesthesia, such as reduction of requirement for inhaled anesthetics and control of pain. The most commonly used drugs in these protocols are local anesthetics, dissociative, and opioids, which may be administered alone or in combinations. We evaluated the records of 200 dogs that underwent various surgical procedures with anesthetic or analgesic CRI in the perioperative period during 2011 and 2012 at the Veterinary Hospital of Franca University (Unifran), and identified possible complications during the transoperative period. Records evaluated included clinical state, laboratory tests, drugs used in premedication and induction, and CRI protocol. Acepromazine and morphine were the main drugs used in premedication. Propofol was used to induce anesthesia alone or in combination with other agents. We evaluated records of the 25 different CRI protocols. Fentanyl was the main drug employed in CRI, either alone or in combination. There were 128 episodes of anesthetic complications during CRI;the most common were hypotension, hypertension, and tachycardia, which occurred in 43 (32%), 35 (26.3%), and 19 (14.2%) dogs, respectively. Cardiac arrhythmia was reported in only 4 dogs. Signs of respiratory depression were present in dogs treated with 6 different CRI protocols. The consumption of isoflurane (vol %) reduced between 15.7% and 21.05% after 30minutes of the CRI in the fentanyl and fentanyl-lidocaine-ketamine CRI groups (p<0.05). In conclusion, CRI is a valid component of balanced anesthesia in dogs, safe, and has a low incidence of adverse effects. However, future studies are warranted to describe the results of the clinical use of CRI to better characterize and refine this technique.
publishDate 2013
dc.date.none.fl_str_mv 2013-07-01
2014-05-27T11:29:54Z
2014-05-27T11:29:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5433/1679-0359.2013v34n4p1807
Semina:Ciencias Agrarias, v. 34, n. 4, p. 1807-1822, 2013.
1676-546X
1679-0359
http://hdl.handle.net/11449/75874
10.5433/1679-0359.2013v34n4p1807
WOS:000328269900033
2-s2.0-84885117512
2-s2.0-84885117512.pdf
url http://dx.doi.org/10.5433/1679-0359.2013v34n4p1807
http://hdl.handle.net/11449/75874
identifier_str_mv Semina:Ciencias Agrarias, v. 34, n. 4, p. 1807-1822, 2013.
1676-546X
1679-0359
10.5433/1679-0359.2013v34n4p1807
WOS:000328269900033
2-s2.0-84885117512
2-s2.0-84885117512.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Semina: Ciências Agrárias
0.349
0,320
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1807-1822
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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