Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparation
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/jocd.13217 http://hdl.handle.net/11449/198188 |
Resumo: | Background: Hydration is an important factor to promote skin barrier function, metabolism, and appearance. In this process, the presence of aquaglyceroporins, envelope and lipid synthesis, and metabolism proteins are essential to provide greater corneocyte cohesion and to form a barrier avoiding transepidermal water loss. Objective: We evaluated the effects of a new topical pigment-free agent containing an Anadenanthera colubrina polysaccharide-rich dermocosmetic preparation (ACP) on the aquaporin-3 (AQP-3), filaggrin (FLG), involucrin (INV), glucocerebrosidase (GBA), and elongation of very-long-chain fatty acid (ELOVL) proteins production in skin human fragments, as well as on the transepidermal water loss in a double-blind placebo-controlled clinical trial. Methods: AQP3, FLG, INV, GBA, and ELOVL3 levels were measured by immunofluorescence analysis in human skin explants. Clinical trial was conducted to evaluate the effects of ACP 1% and ACP 3% on the transepidermal water loss (TEWL). Results: Image and statistical analysis showed that ACP 3% significantly increased at 90% the expression of AQP3. Similarly, ACP 3% was able to promote a significant increase of 68% and 51% in FLG and INV, respectively. ACP 3% produced no effects on the GBA and ELOVL3 proteins. Transepidermal water loss was significantly reduced in human volunteers under treatment with ACP 1% and ACP 3%. Conclusion: ACP reduced transepidermal water loss in a clinical trial, promoting human skin hydration. These effects were related to modulation of the AQP3, FLG, and INV as evidenced by immunofluorescence assay. This way, A colubrina polysaccharide-rich phytopharmaceutical preparation is an effective additive product to skin hydration. |
id |
UNSP_f23720cf23e2652ee7c171d64654bcf8 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/198188 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparationAnadenanthera colubrinaaquaporin-3filaggrininvolucrinskin hydrationTEWLBackground: Hydration is an important factor to promote skin barrier function, metabolism, and appearance. In this process, the presence of aquaglyceroporins, envelope and lipid synthesis, and metabolism proteins are essential to provide greater corneocyte cohesion and to form a barrier avoiding transepidermal water loss. Objective: We evaluated the effects of a new topical pigment-free agent containing an Anadenanthera colubrina polysaccharide-rich dermocosmetic preparation (ACP) on the aquaporin-3 (AQP-3), filaggrin (FLG), involucrin (INV), glucocerebrosidase (GBA), and elongation of very-long-chain fatty acid (ELOVL) proteins production in skin human fragments, as well as on the transepidermal water loss in a double-blind placebo-controlled clinical trial. Methods: AQP3, FLG, INV, GBA, and ELOVL3 levels were measured by immunofluorescence analysis in human skin explants. Clinical trial was conducted to evaluate the effects of ACP 1% and ACP 3% on the transepidermal water loss (TEWL). Results: Image and statistical analysis showed that ACP 3% significantly increased at 90% the expression of AQP3. Similarly, ACP 3% was able to promote a significant increase of 68% and 51% in FLG and INV, respectively. ACP 3% produced no effects on the GBA and ELOVL3 proteins. Transepidermal water loss was significantly reduced in human volunteers under treatment with ACP 1% and ACP 3%. Conclusion: ACP reduced transepidermal water loss in a clinical trial, promoting human skin hydration. These effects were related to modulation of the AQP3, FLG, and INV as evidenced by immunofluorescence assay. This way, A colubrina polysaccharide-rich phytopharmaceutical preparation is an effective additive product to skin hydration.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Research and Development Department Chemyunion Química LtdaDepartment of Pharmacology Laboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTech) Institute of Biosciences São Paulo State University (Unesp)Department of Pharmacology Laboratory of Phytomedicines Pharmacology and Biotechnology (PhytoPharmaTech) Institute of Biosciences São Paulo State University (Unesp)Chemyunion Química LtdaUniversidade Estadual Paulista (Unesp)Katekawa, EdsonCaverzan, JeaniferMussi, LilianCamargo-Junior, Flavio B.Sufi, BiancaPadovani, GiovanaNazato, LucasNogueira, CeciliaMagalhães, Wagner V.Di Stasi, Luiz C. [UNESP]2020-12-12T01:05:57Z2020-12-12T01:05:57Z2020-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1691-1698http://dx.doi.org/10.1111/jocd.13217Journal of Cosmetic Dermatology, v. 19, n. 7, p. 1691-1698, 2020.1473-21651473-2130http://hdl.handle.net/11449/19818810.1111/jocd.132172-s2.0-85075461473Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Cosmetic Dermatologyinfo:eu-repo/semantics/openAccess2021-10-23T09:49:05Zoai:repositorio.unesp.br:11449/198188Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T09:49:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparation |
title |
Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparation |
spellingShingle |
Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparation Katekawa, Edson Anadenanthera colubrina aquaporin-3 filaggrin involucrin skin hydration TEWL |
title_short |
Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparation |
title_full |
Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparation |
title_fullStr |
Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparation |
title_full_unstemmed |
Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparation |
title_sort |
Novel topical skin hydration agent containing Anadenanthera colubrina polysaccharide-standardized herbal preparation |
author |
Katekawa, Edson |
author_facet |
Katekawa, Edson Caverzan, Jeanifer Mussi, Lilian Camargo-Junior, Flavio B. Sufi, Bianca Padovani, Giovana Nazato, Lucas Nogueira, Cecilia Magalhães, Wagner V. Di Stasi, Luiz C. [UNESP] |
author_role |
author |
author2 |
Caverzan, Jeanifer Mussi, Lilian Camargo-Junior, Flavio B. Sufi, Bianca Padovani, Giovana Nazato, Lucas Nogueira, Cecilia Magalhães, Wagner V. Di Stasi, Luiz C. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Chemyunion Química Ltda Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Katekawa, Edson Caverzan, Jeanifer Mussi, Lilian Camargo-Junior, Flavio B. Sufi, Bianca Padovani, Giovana Nazato, Lucas Nogueira, Cecilia Magalhães, Wagner V. Di Stasi, Luiz C. [UNESP] |
dc.subject.por.fl_str_mv |
Anadenanthera colubrina aquaporin-3 filaggrin involucrin skin hydration TEWL |
topic |
Anadenanthera colubrina aquaporin-3 filaggrin involucrin skin hydration TEWL |
description |
Background: Hydration is an important factor to promote skin barrier function, metabolism, and appearance. In this process, the presence of aquaglyceroporins, envelope and lipid synthesis, and metabolism proteins are essential to provide greater corneocyte cohesion and to form a barrier avoiding transepidermal water loss. Objective: We evaluated the effects of a new topical pigment-free agent containing an Anadenanthera colubrina polysaccharide-rich dermocosmetic preparation (ACP) on the aquaporin-3 (AQP-3), filaggrin (FLG), involucrin (INV), glucocerebrosidase (GBA), and elongation of very-long-chain fatty acid (ELOVL) proteins production in skin human fragments, as well as on the transepidermal water loss in a double-blind placebo-controlled clinical trial. Methods: AQP3, FLG, INV, GBA, and ELOVL3 levels were measured by immunofluorescence analysis in human skin explants. Clinical trial was conducted to evaluate the effects of ACP 1% and ACP 3% on the transepidermal water loss (TEWL). Results: Image and statistical analysis showed that ACP 3% significantly increased at 90% the expression of AQP3. Similarly, ACP 3% was able to promote a significant increase of 68% and 51% in FLG and INV, respectively. ACP 3% produced no effects on the GBA and ELOVL3 proteins. Transepidermal water loss was significantly reduced in human volunteers under treatment with ACP 1% and ACP 3%. Conclusion: ACP reduced transepidermal water loss in a clinical trial, promoting human skin hydration. These effects were related to modulation of the AQP3, FLG, and INV as evidenced by immunofluorescence assay. This way, A colubrina polysaccharide-rich phytopharmaceutical preparation is an effective additive product to skin hydration. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:05:57Z 2020-12-12T01:05:57Z 2020-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/jocd.13217 Journal of Cosmetic Dermatology, v. 19, n. 7, p. 1691-1698, 2020. 1473-2165 1473-2130 http://hdl.handle.net/11449/198188 10.1111/jocd.13217 2-s2.0-85075461473 |
url |
http://dx.doi.org/10.1111/jocd.13217 http://hdl.handle.net/11449/198188 |
identifier_str_mv |
Journal of Cosmetic Dermatology, v. 19, n. 7, p. 1691-1698, 2020. 1473-2165 1473-2130 10.1111/jocd.13217 2-s2.0-85075461473 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Cosmetic Dermatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1691-1698 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045954281013248 |