Marcadores magnéticos à base de nanopartículas de ferrita recoberta com quitosana: Influência da quantidade de quitosana na morfologia e na deposição de apatita

• Autor(a) principal: Carvalho, Marina de [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/145395; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2016-09-20/000869696.pdf
• topic: Agentes antineoplasicos; Quitosana; Apatita; Nanopartículas; Ferrita; Chitosan; Apatite

The antitumor drugs can be forwarded to their target by nanocarriers, however direct these drugs specifically to malignant cells is still difficult. However, it is assumed that the breast cancer cells have a high affinity for hydroxyapatite (main mineral phase of bone) because in its development, the occurrence of bone metastases is common. This property could be used to increase the specificity in the association of carriers with breast cancer cells. In this paper, carriers based on: magnetic nanoparticle (ferrite), coated with a biocompatible polymer, biodegradable and non-toxic (chitosan), containing on its surface particles of apatite, were developed. The influence of the proportion of ferrite / chitosan in particle morphology as well as to better anchor the procedure apatite, were evaluated in this study. It is expected that this structure allows to guide the carrier to the target with application of external magnetic field and to encapsulate the drug in the polymer portion of the nanocarrier. Furthermore it is expected that the apatite will increase the affinity of the cancer cell by the carrier. The materials were analyzed by scanning electron microscopy (MEV), infrared spectroscopy (Fourier Transform Infrared Spectroscopy, FTIR) and electrophoretic mobility measurements to determine the particle surface potential (zeta) and size distribution analysis. The proportion of ferrite/chitosan 2: 1 yielded more spherical particles. The treatment with NaOH ferrite particles coated with chitosan resulted in an increase in the amount anchored apatite. This study may contribute to the improvement of methods of diagnosis and treatment of cancer by techniques using magnetic materials as a probe and not require the use of ionizing radiation such as biosusceptometry (BAC) and magnetic hyperthermia