IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.17523/bia.2019.v76.e1450 http://hdl.handle.net/11449/196442 |
Resumo: | Gastrointestinal nematodes can affect sheep productivity via severe weight loss, anemia and death. Infection control is generally performed with synthetic anthelmintic compounds; however, indiscriminate use of these drugs can stimulate the emergence of resistant nematodes. Thus, alternatives to the use of synthetic anthelmintic compounds have been proposed, such as the inclusion of medicinal plants in animal feed. The objective of this study was evaluate the anthelmintic activity of the leaves of the medicinal plant Psidium cattleianum Sabine (Araca) through its hydroalcoholic extract, and using in vitro assays with the eggs and larvae of gastrointestinal nematodes obtained from naturally infected donor sheep. The extract exhibited good in vitro ovicidal and larvicidal activity, with IC50 values of 0.55 mg mL(-1) for egg hatching inhibition, 0.20 mg mL-1 for larval development inhibition and an efficiency greater than 80% in the inhibition of larval migration at all concentrations evaluated (IC50 < 0.19 mg/mL). Phytochemical analysis detected higher concentrations of saponins, flavonoids, cardiac glycosides, anthraquinones and tannins in the extract. Our results demonstrated that the Psidium cattleianum Sabine's leaves exhibit in vitro anthelmintic activity, which suggests that in addition to its other medicinal properties, this plant can help control gastrointestinal nematodes in sheep. Future in vivo assays should be performed to confirm antiparasitic efficacy. |
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IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEPAracaPhytotherapyHaemonchus contortusGastrointestinal nematodes can affect sheep productivity via severe weight loss, anemia and death. Infection control is generally performed with synthetic anthelmintic compounds; however, indiscriminate use of these drugs can stimulate the emergence of resistant nematodes. Thus, alternatives to the use of synthetic anthelmintic compounds have been proposed, such as the inclusion of medicinal plants in animal feed. The objective of this study was evaluate the anthelmintic activity of the leaves of the medicinal plant Psidium cattleianum Sabine (Araca) through its hydroalcoholic extract, and using in vitro assays with the eggs and larvae of gastrointestinal nematodes obtained from naturally infected donor sheep. The extract exhibited good in vitro ovicidal and larvicidal activity, with IC50 values of 0.55 mg mL(-1) for egg hatching inhibition, 0.20 mg mL-1 for larval development inhibition and an efficiency greater than 80% in the inhibition of larval migration at all concentrations evaluated (IC50 < 0.19 mg/mL). Phytochemical analysis detected higher concentrations of saponins, flavonoids, cardiac glycosides, anthraquinones and tannins in the extract. Our results demonstrated that the Psidium cattleianum Sabine's leaves exhibit in vitro anthelmintic activity, which suggests that in addition to its other medicinal properties, this plant can help control gastrointestinal nematodes in sheep. Future in vivo assays should be performed to confirm antiparasitic efficacy.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, FEIS, Dept Fis & Quim, Sao Paulo, SP, BrazilUniv Estadual Paulista, Dept Biol & Zootecnia, FEIS, Sao Paulo, SP, BrazilUniv Estadual Montes Claros, Campus Univ Prof Darcy Ribeiro, Montes Claros, MG, BrazilUniv Estadual Paulista, FEIS, Dept Fis & Quim, Sao Paulo, SP, BrazilUniv Estadual Paulista, Dept Biol & Zootecnia, FEIS, Sao Paulo, SP, BrazilFAPESP: 2012/22096-7Inst ZootecniaUniversidade Estadual Paulista (Unesp)Univ Estadual Montes ClarosPiza, M. L. S. T. [UNESP]Feboli, A. [UNESP]Augusto, J. G. [UNESP]Anjos, L. A. [UNESP]Laurentiz, A. C. [UNESP]Royo, V. A.Alvarenga, F. Q.Laurentiz, R. S. [UNESP]2020-12-10T19:45:07Z2020-12-10T19:45:07Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8http://dx.doi.org/10.17523/bia.2019.v76.e1450Boletim De Industria Animal. Nova Odessa: Inst Zootecnia, v. 76, 8 p., 2019.0067-9615http://hdl.handle.net/11449/19644210.17523/bia.2019.v76.e1450WOS:000504417900004Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBoletim De Industria Animalinfo:eu-repo/semantics/openAccess2024-07-10T14:07:58Zoai:repositorio.unesp.br:11449/196442Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:27:45.178044Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP |
title |
IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP |
spellingShingle |
IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP Piza, M. L. S. T. [UNESP] Araca Phytotherapy Haemonchus contortus |
title_short |
IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP |
title_full |
IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP |
title_fullStr |
IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP |
title_full_unstemmed |
IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP |
title_sort |
IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP |
author |
Piza, M. L. S. T. [UNESP] |
author_facet |
Piza, M. L. S. T. [UNESP] Feboli, A. [UNESP] Augusto, J. G. [UNESP] Anjos, L. A. [UNESP] Laurentiz, A. C. [UNESP] Royo, V. A. Alvarenga, F. Q. Laurentiz, R. S. [UNESP] |
author_role |
author |
author2 |
Feboli, A. [UNESP] Augusto, J. G. [UNESP] Anjos, L. A. [UNESP] Laurentiz, A. C. [UNESP] Royo, V. A. Alvarenga, F. Q. Laurentiz, R. S. [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Estadual Montes Claros |
dc.contributor.author.fl_str_mv |
Piza, M. L. S. T. [UNESP] Feboli, A. [UNESP] Augusto, J. G. [UNESP] Anjos, L. A. [UNESP] Laurentiz, A. C. [UNESP] Royo, V. A. Alvarenga, F. Q. Laurentiz, R. S. [UNESP] |
dc.subject.por.fl_str_mv |
Araca Phytotherapy Haemonchus contortus |
topic |
Araca Phytotherapy Haemonchus contortus |
description |
Gastrointestinal nematodes can affect sheep productivity via severe weight loss, anemia and death. Infection control is generally performed with synthetic anthelmintic compounds; however, indiscriminate use of these drugs can stimulate the emergence of resistant nematodes. Thus, alternatives to the use of synthetic anthelmintic compounds have been proposed, such as the inclusion of medicinal plants in animal feed. The objective of this study was evaluate the anthelmintic activity of the leaves of the medicinal plant Psidium cattleianum Sabine (Araca) through its hydroalcoholic extract, and using in vitro assays with the eggs and larvae of gastrointestinal nematodes obtained from naturally infected donor sheep. The extract exhibited good in vitro ovicidal and larvicidal activity, with IC50 values of 0.55 mg mL(-1) for egg hatching inhibition, 0.20 mg mL-1 for larval development inhibition and an efficiency greater than 80% in the inhibition of larval migration at all concentrations evaluated (IC50 < 0.19 mg/mL). Phytochemical analysis detected higher concentrations of saponins, flavonoids, cardiac glycosides, anthraquinones and tannins in the extract. Our results demonstrated that the Psidium cattleianum Sabine's leaves exhibit in vitro anthelmintic activity, which suggests that in addition to its other medicinal properties, this plant can help control gastrointestinal nematodes in sheep. Future in vivo assays should be performed to confirm antiparasitic efficacy. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 2020-12-10T19:45:07Z 2020-12-10T19:45:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.17523/bia.2019.v76.e1450 Boletim De Industria Animal. Nova Odessa: Inst Zootecnia, v. 76, 8 p., 2019. 0067-9615 http://hdl.handle.net/11449/196442 10.17523/bia.2019.v76.e1450 WOS:000504417900004 |
url |
http://dx.doi.org/10.17523/bia.2019.v76.e1450 http://hdl.handle.net/11449/196442 |
identifier_str_mv |
Boletim De Industria Animal. Nova Odessa: Inst Zootecnia, v. 76, 8 p., 2019. 0067-9615 10.17523/bia.2019.v76.e1450 WOS:000504417900004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Boletim De Industria Animal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
8 |
dc.publisher.none.fl_str_mv |
Inst Zootecnia |
publisher.none.fl_str_mv |
Inst Zootecnia |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129322773381120 |