IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP

Detalhes bibliográficos
Autor(a) principal: Piza, M. L. S. T. [UNESP]
Data de Publicação: 2019
Outros Autores: Feboli, A. [UNESP], Augusto, J. G. [UNESP], Anjos, L. A. [UNESP], Laurentiz, A. C. [UNESP], Royo, V. A., Alvarenga, F. Q., Laurentiz, R. S. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.17523/bia.2019.v76.e1450
http://hdl.handle.net/11449/196442
Resumo: Gastrointestinal nematodes can affect sheep productivity via severe weight loss, anemia and death. Infection control is generally performed with synthetic anthelmintic compounds; however, indiscriminate use of these drugs can stimulate the emergence of resistant nematodes. Thus, alternatives to the use of synthetic anthelmintic compounds have been proposed, such as the inclusion of medicinal plants in animal feed. The objective of this study was evaluate the anthelmintic activity of the leaves of the medicinal plant Psidium cattleianum Sabine (Araca) through its hydroalcoholic extract, and using in vitro assays with the eggs and larvae of gastrointestinal nematodes obtained from naturally infected donor sheep. The extract exhibited good in vitro ovicidal and larvicidal activity, with IC50 values of 0.55 mg mL(-1) for egg hatching inhibition, 0.20 mg mL-1 for larval development inhibition and an efficiency greater than 80% in the inhibition of larval migration at all concentrations evaluated (IC50 < 0.19 mg/mL). Phytochemical analysis detected higher concentrations of saponins, flavonoids, cardiac glycosides, anthraquinones and tannins in the extract. Our results demonstrated that the Psidium cattleianum Sabine's leaves exhibit in vitro anthelmintic activity, which suggests that in addition to its other medicinal properties, this plant can help control gastrointestinal nematodes in sheep. Future in vivo assays should be performed to confirm antiparasitic efficacy.
id UNSP_f27b308c320df2f237c85a15416fa705
oai_identifier_str oai:repositorio.unesp.br:11449/196442
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEPAracaPhytotherapyHaemonchus contortusGastrointestinal nematodes can affect sheep productivity via severe weight loss, anemia and death. Infection control is generally performed with synthetic anthelmintic compounds; however, indiscriminate use of these drugs can stimulate the emergence of resistant nematodes. Thus, alternatives to the use of synthetic anthelmintic compounds have been proposed, such as the inclusion of medicinal plants in animal feed. The objective of this study was evaluate the anthelmintic activity of the leaves of the medicinal plant Psidium cattleianum Sabine (Araca) through its hydroalcoholic extract, and using in vitro assays with the eggs and larvae of gastrointestinal nematodes obtained from naturally infected donor sheep. The extract exhibited good in vitro ovicidal and larvicidal activity, with IC50 values of 0.55 mg mL(-1) for egg hatching inhibition, 0.20 mg mL-1 for larval development inhibition and an efficiency greater than 80% in the inhibition of larval migration at all concentrations evaluated (IC50 < 0.19 mg/mL). Phytochemical analysis detected higher concentrations of saponins, flavonoids, cardiac glycosides, anthraquinones and tannins in the extract. Our results demonstrated that the Psidium cattleianum Sabine's leaves exhibit in vitro anthelmintic activity, which suggests that in addition to its other medicinal properties, this plant can help control gastrointestinal nematodes in sheep. Future in vivo assays should be performed to confirm antiparasitic efficacy.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, FEIS, Dept Fis & Quim, Sao Paulo, SP, BrazilUniv Estadual Paulista, Dept Biol & Zootecnia, FEIS, Sao Paulo, SP, BrazilUniv Estadual Montes Claros, Campus Univ Prof Darcy Ribeiro, Montes Claros, MG, BrazilUniv Estadual Paulista, FEIS, Dept Fis & Quim, Sao Paulo, SP, BrazilUniv Estadual Paulista, Dept Biol & Zootecnia, FEIS, Sao Paulo, SP, BrazilFAPESP: 2012/22096-7Inst ZootecniaUniversidade Estadual Paulista (Unesp)Univ Estadual Montes ClarosPiza, M. L. S. T. [UNESP]Feboli, A. [UNESP]Augusto, J. G. [UNESP]Anjos, L. A. [UNESP]Laurentiz, A. C. [UNESP]Royo, V. A.Alvarenga, F. Q.Laurentiz, R. S. [UNESP]2020-12-10T19:45:07Z2020-12-10T19:45:07Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8http://dx.doi.org/10.17523/bia.2019.v76.e1450Boletim De Industria Animal. Nova Odessa: Inst Zootecnia, v. 76, 8 p., 2019.0067-9615http://hdl.handle.net/11449/19644210.17523/bia.2019.v76.e1450WOS:000504417900004Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBoletim De Industria Animalinfo:eu-repo/semantics/openAccess2024-07-10T14:07:58Zoai:repositorio.unesp.br:11449/196442Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:27:45.178044Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP
title IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP
spellingShingle IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP
Piza, M. L. S. T. [UNESP]
Araca
Phytotherapy
Haemonchus contortus
title_short IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP
title_full IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP
title_fullStr IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP
title_full_unstemmed IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP
title_sort IN VITRO OVICIDAL AND LARVICIDAL ACTIVITY OF PSIDIUM CATTLEIANUM SABINE LEAVES AGAINST GASTROINTESTINAL NEMATODES OF SHEEP
author Piza, M. L. S. T. [UNESP]
author_facet Piza, M. L. S. T. [UNESP]
Feboli, A. [UNESP]
Augusto, J. G. [UNESP]
Anjos, L. A. [UNESP]
Laurentiz, A. C. [UNESP]
Royo, V. A.
Alvarenga, F. Q.
Laurentiz, R. S. [UNESP]
author_role author
author2 Feboli, A. [UNESP]
Augusto, J. G. [UNESP]
Anjos, L. A. [UNESP]
Laurentiz, A. C. [UNESP]
Royo, V. A.
Alvarenga, F. Q.
Laurentiz, R. S. [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Univ Estadual Montes Claros
dc.contributor.author.fl_str_mv Piza, M. L. S. T. [UNESP]
Feboli, A. [UNESP]
Augusto, J. G. [UNESP]
Anjos, L. A. [UNESP]
Laurentiz, A. C. [UNESP]
Royo, V. A.
Alvarenga, F. Q.
Laurentiz, R. S. [UNESP]
dc.subject.por.fl_str_mv Araca
Phytotherapy
Haemonchus contortus
topic Araca
Phytotherapy
Haemonchus contortus
description Gastrointestinal nematodes can affect sheep productivity via severe weight loss, anemia and death. Infection control is generally performed with synthetic anthelmintic compounds; however, indiscriminate use of these drugs can stimulate the emergence of resistant nematodes. Thus, alternatives to the use of synthetic anthelmintic compounds have been proposed, such as the inclusion of medicinal plants in animal feed. The objective of this study was evaluate the anthelmintic activity of the leaves of the medicinal plant Psidium cattleianum Sabine (Araca) through its hydroalcoholic extract, and using in vitro assays with the eggs and larvae of gastrointestinal nematodes obtained from naturally infected donor sheep. The extract exhibited good in vitro ovicidal and larvicidal activity, with IC50 values of 0.55 mg mL(-1) for egg hatching inhibition, 0.20 mg mL-1 for larval development inhibition and an efficiency greater than 80% in the inhibition of larval migration at all concentrations evaluated (IC50 < 0.19 mg/mL). Phytochemical analysis detected higher concentrations of saponins, flavonoids, cardiac glycosides, anthraquinones and tannins in the extract. Our results demonstrated that the Psidium cattleianum Sabine's leaves exhibit in vitro anthelmintic activity, which suggests that in addition to its other medicinal properties, this plant can help control gastrointestinal nematodes in sheep. Future in vivo assays should be performed to confirm antiparasitic efficacy.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
2020-12-10T19:45:07Z
2020-12-10T19:45:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.17523/bia.2019.v76.e1450
Boletim De Industria Animal. Nova Odessa: Inst Zootecnia, v. 76, 8 p., 2019.
0067-9615
http://hdl.handle.net/11449/196442
10.17523/bia.2019.v76.e1450
WOS:000504417900004
url http://dx.doi.org/10.17523/bia.2019.v76.e1450
http://hdl.handle.net/11449/196442
identifier_str_mv Boletim De Industria Animal. Nova Odessa: Inst Zootecnia, v. 76, 8 p., 2019.
0067-9615
10.17523/bia.2019.v76.e1450
WOS:000504417900004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Boletim De Industria Animal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
dc.publisher.none.fl_str_mv Inst Zootecnia
publisher.none.fl_str_mv Inst Zootecnia
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129322773381120