Endocannabinoid system and periodontitis: mechanisms and therapeutic implications
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | https://hdl.handle.net/11449/256140 |
Resumo: | Introduction: Periodontitis is a major public health problem. Although the principle of periodontitis therapy is mainly focused on removing dental biofilm and associated factors, its physiopathology enrolls different molecular and inflammatory events related to the host immune system, as the participation of the endocannabinoid system. Objective: This review aimed to explore and elucidate the mechanisms and roles of the endocannabinoid system on periodontitis physiopathology and its possibilities for future related therapies. Material and method: An electronic search was carried out on the PubMed platform for studies involving the action of the endocannabinoid system on periodontitis. Result: Nineteen clinical and preclinical studies were included in this narrative review. Conclusion: Cannabinoid receptors type 1 and 2 are integral components of the endocannabinoid system, manifesting in various forms in the periodontal tissues. The actions and mechanisms through which cannabinoid receptors are activated in healthy or inflamed sites remain the focus of ongoing investigations. Moreover, phytocannabinoids and synthetic cannabinoids show therapeutic potential, with pre-clinical studies indicating benefits in reducing inflammation and facilitating tissue repair. |
id |
UNSP_f2ab6dbbbcaa23c3bc77ef1683de2acd |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/256140 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Endocannabinoid system and periodontitis: mechanisms and therapeutic implicationsSistema endocanabinoide e periodontite: mecanismos e implicações terapêuticasCannabinoidsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2InflammationPeriodontitisCanabinoidesReceptor CB1 de canabinoideReceptor CB2 de canabinoideInflamaçãoPeriodontiteIntroduction: Periodontitis is a major public health problem. Although the principle of periodontitis therapy is mainly focused on removing dental biofilm and associated factors, its physiopathology enrolls different molecular and inflammatory events related to the host immune system, as the participation of the endocannabinoid system. Objective: This review aimed to explore and elucidate the mechanisms and roles of the endocannabinoid system on periodontitis physiopathology and its possibilities for future related therapies. Material and method: An electronic search was carried out on the PubMed platform for studies involving the action of the endocannabinoid system on periodontitis. Result: Nineteen clinical and preclinical studies were included in this narrative review. Conclusion: Cannabinoid receptors type 1 and 2 are integral components of the endocannabinoid system, manifesting in various forms in the periodontal tissues. The actions and mechanisms through which cannabinoid receptors are activated in healthy or inflamed sites remain the focus of ongoing investigations. Moreover, phytocannabinoids and synthetic cannabinoids show therapeutic potential, with pre-clinical studies indicating benefits in reducing inflammation and facilitating tissue repair.Introdução: A periodontite é um importante problema de saúde pública. Embora o princípio da terapia da periodontite esteja focado principalmente na remoção do biofilme dental e dos fatores associados, sua fisiopatologia registra diferentes eventos moleculares e inflamatórios relacionados ao sistema imunológico do hospedeiro, como a participação do sistema endocanabinoide. Objetivo: Esta revisão teve como objetivo explorar e elucidar os mecanismos e papéis do sistema endocanabinoide na fisiopatologia da periodontite e suas possibilidades para futuras terapias relacionadas. Material e método: Realizou-se uma busca eletrônica na plataforma PubMed por estudos envolvendo a ação do sistema endocanabinoide sobre a periodontite. Resultado: Dezenove estudos clínicos e pré-clínicos foram incluídos nesta revisão narrativa. Conclusão: Os receptores canabinoides tipo 1 e 2 são componentes integrais do sistema endocanabinoide e manifestam-se de várias formas nos tecidos periodontais. As ações e mecanismos através dos quais os receptores canabinoides são ativados em locais saudáveis ou inflamados continuam a ser o foco de investigações em curso. Além disso, os fitocanabinoides e canabinoides sintéticos apresentam potencial como tratamentos, com estudos pré-clínicos indicando benefícios na redução da inflamação e na facilitação da reparação dos tecidos.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Versão final do editorFAPESP: 2023/06881-0Universidade Estadual Paulista "Julio de Mesquita Filho" - UNESP2024-06-27T17:12:57Z2024-06-27T17:12:57Z2023-12-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSoares LFF, Faria LV, Cirelli JA. Endocannabinoid system and periodontitis: mechanisms and therapeutic implications. Rev Odontol UNESP. 2023; 52: e20230031. https://doi.org/10.1590/1807-2577.031231807-2577https://hdl.handle.net/11449/25614010.1590/1807-2577.031231884800119982607937338954848691726285936934501210000-0003-2336-99460000-0003-4174-29430000-0002-7082-9290engRevista de Odontologia da UNESPSoares, Lélio Fernando Ferreira [UNESP]Faria, Luan Viana [UNESP]Cirelli, Joni Augusto [UNESP]info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2024-06-28T06:29:36Zoai:repositorio.unesp.br:11449/256140Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:03:26.292590Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Endocannabinoid system and periodontitis: mechanisms and therapeutic implications Sistema endocanabinoide e periodontite: mecanismos e implicações terapêuticas |
title |
Endocannabinoid system and periodontitis: mechanisms and therapeutic implications |
spellingShingle |
Endocannabinoid system and periodontitis: mechanisms and therapeutic implications Soares, Lélio Fernando Ferreira [UNESP] Cannabinoids Receptor, Cannabinoid, CB1 Receptor, Cannabinoid, CB2 Inflammation Periodontitis Canabinoides Receptor CB1 de canabinoide Receptor CB2 de canabinoide Inflamação Periodontite |
title_short |
Endocannabinoid system and periodontitis: mechanisms and therapeutic implications |
title_full |
Endocannabinoid system and periodontitis: mechanisms and therapeutic implications |
title_fullStr |
Endocannabinoid system and periodontitis: mechanisms and therapeutic implications |
title_full_unstemmed |
Endocannabinoid system and periodontitis: mechanisms and therapeutic implications |
title_sort |
Endocannabinoid system and periodontitis: mechanisms and therapeutic implications |
author |
Soares, Lélio Fernando Ferreira [UNESP] |
author_facet |
Soares, Lélio Fernando Ferreira [UNESP] Faria, Luan Viana [UNESP] Cirelli, Joni Augusto [UNESP] |
author_role |
author |
author2 |
Faria, Luan Viana [UNESP] Cirelli, Joni Augusto [UNESP] |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Soares, Lélio Fernando Ferreira [UNESP] Faria, Luan Viana [UNESP] Cirelli, Joni Augusto [UNESP] |
dc.subject.por.fl_str_mv |
Cannabinoids Receptor, Cannabinoid, CB1 Receptor, Cannabinoid, CB2 Inflammation Periodontitis Canabinoides Receptor CB1 de canabinoide Receptor CB2 de canabinoide Inflamação Periodontite |
topic |
Cannabinoids Receptor, Cannabinoid, CB1 Receptor, Cannabinoid, CB2 Inflammation Periodontitis Canabinoides Receptor CB1 de canabinoide Receptor CB2 de canabinoide Inflamação Periodontite |
description |
Introduction: Periodontitis is a major public health problem. Although the principle of periodontitis therapy is mainly focused on removing dental biofilm and associated factors, its physiopathology enrolls different molecular and inflammatory events related to the host immune system, as the participation of the endocannabinoid system. Objective: This review aimed to explore and elucidate the mechanisms and roles of the endocannabinoid system on periodontitis physiopathology and its possibilities for future related therapies. Material and method: An electronic search was carried out on the PubMed platform for studies involving the action of the endocannabinoid system on periodontitis. Result: Nineteen clinical and preclinical studies were included in this narrative review. Conclusion: Cannabinoid receptors type 1 and 2 are integral components of the endocannabinoid system, manifesting in various forms in the periodontal tissues. The actions and mechanisms through which cannabinoid receptors are activated in healthy or inflamed sites remain the focus of ongoing investigations. Moreover, phytocannabinoids and synthetic cannabinoids show therapeutic potential, with pre-clinical studies indicating benefits in reducing inflammation and facilitating tissue repair. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-04 2024-06-27T17:12:57Z 2024-06-27T17:12:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Soares LFF, Faria LV, Cirelli JA. Endocannabinoid system and periodontitis: mechanisms and therapeutic implications. Rev Odontol UNESP. 2023; 52: e20230031. https://doi.org/10.1590/1807-2577.03123 1807-2577 https://hdl.handle.net/11449/256140 10.1590/1807-2577.03123 1884800119982607 9373389548486917 2628593693450121 0000-0003-2336-9946 0000-0003-4174-2943 0000-0002-7082-9290 |
identifier_str_mv |
Soares LFF, Faria LV, Cirelli JA. Endocannabinoid system and periodontitis: mechanisms and therapeutic implications. Rev Odontol UNESP. 2023; 52: e20230031. https://doi.org/10.1590/1807-2577.03123 1807-2577 10.1590/1807-2577.03123 1884800119982607 9373389548486917 2628593693450121 0000-0003-2336-9946 0000-0003-4174-2943 0000-0002-7082-9290 |
url |
https://hdl.handle.net/11449/256140 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista de Odontologia da UNESP |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista "Julio de Mesquita Filho" - UNESP |
publisher.none.fl_str_mv |
Universidade Estadual Paulista "Julio de Mesquita Filho" - UNESP |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128747601133568 |