Endocannabinoid system and periodontitis: mechanisms and therapeutic implications

Detalhes bibliográficos
Autor(a) principal: Soares, Lélio Fernando Ferreira [UNESP]
Data de Publicação: 2023
Outros Autores: Faria, Luan Viana [UNESP], Cirelli, Joni Augusto [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: https://hdl.handle.net/11449/256140
Resumo: Introduction: Periodontitis is a major public health problem. Although the principle of periodontitis therapy is mainly focused on removing dental biofilm and associated factors, its physiopathology enrolls different molecular and inflammatory events related to the host immune system, as the participation of the endocannabinoid system. Objective: This review aimed to explore and elucidate the mechanisms and roles of the endocannabinoid system on periodontitis physiopathology and its possibilities for future related therapies. Material and method: An electronic search was carried out on the PubMed platform for studies involving the action of the endocannabinoid system on periodontitis. Result: Nineteen clinical and preclinical studies were included in this narrative review. Conclusion: Cannabinoid receptors type 1 and 2 are integral components of the endocannabinoid system, manifesting in various forms in the periodontal tissues. The actions and mechanisms through which cannabinoid receptors are activated in healthy or inflamed sites remain the focus of ongoing investigations. Moreover, phytocannabinoids and synthetic cannabinoids show therapeutic potential, with pre-clinical studies indicating benefits in reducing inflammation and facilitating tissue repair.
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spelling Endocannabinoid system and periodontitis: mechanisms and therapeutic implicationsSistema endocanabinoide e periodontite: mecanismos e implicações terapêuticasCannabinoidsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2InflammationPeriodontitisCanabinoidesReceptor CB1 de canabinoideReceptor CB2 de canabinoideInflamaçãoPeriodontiteIntroduction: Periodontitis is a major public health problem. Although the principle of periodontitis therapy is mainly focused on removing dental biofilm and associated factors, its physiopathology enrolls different molecular and inflammatory events related to the host immune system, as the participation of the endocannabinoid system. Objective: This review aimed to explore and elucidate the mechanisms and roles of the endocannabinoid system on periodontitis physiopathology and its possibilities for future related therapies. Material and method: An electronic search was carried out on the PubMed platform for studies involving the action of the endocannabinoid system on periodontitis. Result: Nineteen clinical and preclinical studies were included in this narrative review. Conclusion: Cannabinoid receptors type 1 and 2 are integral components of the endocannabinoid system, manifesting in various forms in the periodontal tissues. The actions and mechanisms through which cannabinoid receptors are activated in healthy or inflamed sites remain the focus of ongoing investigations. Moreover, phytocannabinoids and synthetic cannabinoids show therapeutic potential, with pre-clinical studies indicating benefits in reducing inflammation and facilitating tissue repair.Introdução: A periodontite é um importante problema de saúde pública. Embora o princípio da terapia da periodontite esteja focado principalmente na remoção do biofilme dental e dos fatores associados, sua fisiopatologia registra diferentes eventos moleculares e inflamatórios relacionados ao sistema imunológico do hospedeiro, como a participação do sistema endocanabinoide. Objetivo: Esta revisão teve como objetivo explorar e elucidar os mecanismos e papéis do sistema endocanabinoide na fisiopatologia da periodontite e suas possibilidades para futuras terapias relacionadas. Material e método: Realizou-se uma busca eletrônica na plataforma PubMed por estudos envolvendo a ação do sistema endocanabinoide sobre a periodontite. Resultado: Dezenove estudos clínicos e pré-clínicos foram incluídos nesta revisão narrativa. Conclusão: Os receptores canabinoides tipo 1 e 2 são componentes integrais do sistema endocanabinoide e manifestam-se de várias formas nos tecidos periodontais. As ações e mecanismos através dos quais os receptores canabinoides são ativados em locais saudáveis ou inflamados continuam a ser o foco de investigações em curso. Além disso, os fitocanabinoides e canabinoides sintéticos apresentam potencial como tratamentos, com estudos pré-clínicos indicando benefícios na redução da inflamação e na facilitação da reparação dos tecidos.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Versão final do editorFAPESP: 2023/06881-0Universidade Estadual Paulista "Julio de Mesquita Filho" - UNESP2024-06-27T17:12:57Z2024-06-27T17:12:57Z2023-12-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSoares LFF, Faria LV, Cirelli JA. Endocannabinoid system and periodontitis: mechanisms and therapeutic implications. Rev Odontol UNESP. 2023; 52: e20230031. https://doi.org/10.1590/1807-2577.031231807-2577https://hdl.handle.net/11449/25614010.1590/1807-2577.031231884800119982607937338954848691726285936934501210000-0003-2336-99460000-0003-4174-29430000-0002-7082-9290engRevista de Odontologia da UNESPSoares, Lélio Fernando Ferreira [UNESP]Faria, Luan Viana [UNESP]Cirelli, Joni Augusto [UNESP]info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2024-06-28T06:29:36Zoai:repositorio.unesp.br:11449/256140Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:03:26.292590Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Endocannabinoid system and periodontitis: mechanisms and therapeutic implications
Sistema endocanabinoide e periodontite: mecanismos e implicações terapêuticas
title Endocannabinoid system and periodontitis: mechanisms and therapeutic implications
spellingShingle Endocannabinoid system and periodontitis: mechanisms and therapeutic implications
Soares, Lélio Fernando Ferreira [UNESP]
Cannabinoids
Receptor, Cannabinoid, CB1
Receptor, Cannabinoid, CB2
Inflammation
Periodontitis
Canabinoides
Receptor CB1 de canabinoide
Receptor CB2 de canabinoide
Inflamação
Periodontite
title_short Endocannabinoid system and periodontitis: mechanisms and therapeutic implications
title_full Endocannabinoid system and periodontitis: mechanisms and therapeutic implications
title_fullStr Endocannabinoid system and periodontitis: mechanisms and therapeutic implications
title_full_unstemmed Endocannabinoid system and periodontitis: mechanisms and therapeutic implications
title_sort Endocannabinoid system and periodontitis: mechanisms and therapeutic implications
author Soares, Lélio Fernando Ferreira [UNESP]
author_facet Soares, Lélio Fernando Ferreira [UNESP]
Faria, Luan Viana [UNESP]
Cirelli, Joni Augusto [UNESP]
author_role author
author2 Faria, Luan Viana [UNESP]
Cirelli, Joni Augusto [UNESP]
author2_role author
author
dc.contributor.author.fl_str_mv Soares, Lélio Fernando Ferreira [UNESP]
Faria, Luan Viana [UNESP]
Cirelli, Joni Augusto [UNESP]
dc.subject.por.fl_str_mv Cannabinoids
Receptor, Cannabinoid, CB1
Receptor, Cannabinoid, CB2
Inflammation
Periodontitis
Canabinoides
Receptor CB1 de canabinoide
Receptor CB2 de canabinoide
Inflamação
Periodontite
topic Cannabinoids
Receptor, Cannabinoid, CB1
Receptor, Cannabinoid, CB2
Inflammation
Periodontitis
Canabinoides
Receptor CB1 de canabinoide
Receptor CB2 de canabinoide
Inflamação
Periodontite
description Introduction: Periodontitis is a major public health problem. Although the principle of periodontitis therapy is mainly focused on removing dental biofilm and associated factors, its physiopathology enrolls different molecular and inflammatory events related to the host immune system, as the participation of the endocannabinoid system. Objective: This review aimed to explore and elucidate the mechanisms and roles of the endocannabinoid system on periodontitis physiopathology and its possibilities for future related therapies. Material and method: An electronic search was carried out on the PubMed platform for studies involving the action of the endocannabinoid system on periodontitis. Result: Nineteen clinical and preclinical studies were included in this narrative review. Conclusion: Cannabinoid receptors type 1 and 2 are integral components of the endocannabinoid system, manifesting in various forms in the periodontal tissues. The actions and mechanisms through which cannabinoid receptors are activated in healthy or inflamed sites remain the focus of ongoing investigations. Moreover, phytocannabinoids and synthetic cannabinoids show therapeutic potential, with pre-clinical studies indicating benefits in reducing inflammation and facilitating tissue repair.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-04
2024-06-27T17:12:57Z
2024-06-27T17:12:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Soares LFF, Faria LV, Cirelli JA. Endocannabinoid system and periodontitis: mechanisms and therapeutic implications. Rev Odontol UNESP. 2023; 52: e20230031. https://doi.org/10.1590/1807-2577.03123
1807-2577
https://hdl.handle.net/11449/256140
10.1590/1807-2577.03123
1884800119982607
9373389548486917
2628593693450121
0000-0003-2336-9946
0000-0003-4174-2943
0000-0002-7082-9290
identifier_str_mv Soares LFF, Faria LV, Cirelli JA. Endocannabinoid system and periodontitis: mechanisms and therapeutic implications. Rev Odontol UNESP. 2023; 52: e20230031. https://doi.org/10.1590/1807-2577.03123
1807-2577
10.1590/1807-2577.03123
1884800119982607
9373389548486917
2628593693450121
0000-0003-2336-9946
0000-0003-4174-2943
0000-0002-7082-9290
url https://hdl.handle.net/11449/256140
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista de Odontologia da UNESP
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Estadual Paulista "Julio de Mesquita Filho" - UNESP
publisher.none.fl_str_mv Universidade Estadual Paulista "Julio de Mesquita Filho" - UNESP
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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