Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10103-021-03341-x http://hdl.handle.net/11449/207773 |
Resumo: | The present study aimed to evaluate the new heterologous fibrin biopolymer associated, or not, with photobiomodulation therapy for application in tendon injuries, considered a serious and common orthopedic problem. Thus, 84 Rattus norvegicus had partial transection of the calcaneus tendon (PTCT) and were randomly divided into: control (CG); heterologous fibrin biopolymer (HFB); photobiomodulation (PBM); heterologous fibrin biopolymer + photobiomodulation (HFB + PBM). The animals received HFB immediately after PTCT, while PBM (660 nm, 40 mW, 0.23 J) started 24 h post injury and followed every 24 h for 7, 14, and 21 days. The results of the edema volume showed that after 24 h of PTCT, there was no statistical difference among the groups. After 7, 14, and 21 days, it was observed that the treatment groups were effective in reducing edema when compared to the control. The HFB had the highest edema volume reduction after 21 days of treatment. The treatment groups did not induce tissue necrosis or infections on the histopathological analysis. Tenocyte proliferation, granulation tissue, and collagen formation were observed in the PTCT area in the HFB and HFB + PBM groups, which culminated a better repair process when compared to the CG in the 3 experimental periods. Interestingly, the PBM group revealed, in histological analysis, major tendon injury after 7 days; however, in the periods of 14 and 21 days, the PBM had a better repair process compared to the CG. In the quantification of collagen, there was no statistical difference between the groups in the 3 experimental periods. The findings suggest that the HFB and PBM treatments, isolated or associated, were effective in reducing the volume of the edema, stimulating the repair process. However, the use of HFB alone was more effective in promoting the tendon repair process. Thus, the present study consolidates previous studies of tendon repair with this new HFB. Future clinical trials will be needed to validate this proposal. |
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Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in ratsCalcaneus tendonHeterologous fibrin biopolymerPhotobiomodulationRatsTissue repairThe present study aimed to evaluate the new heterologous fibrin biopolymer associated, or not, with photobiomodulation therapy for application in tendon injuries, considered a serious and common orthopedic problem. Thus, 84 Rattus norvegicus had partial transection of the calcaneus tendon (PTCT) and were randomly divided into: control (CG); heterologous fibrin biopolymer (HFB); photobiomodulation (PBM); heterologous fibrin biopolymer + photobiomodulation (HFB + PBM). The animals received HFB immediately after PTCT, while PBM (660 nm, 40 mW, 0.23 J) started 24 h post injury and followed every 24 h for 7, 14, and 21 days. The results of the edema volume showed that after 24 h of PTCT, there was no statistical difference among the groups. After 7, 14, and 21 days, it was observed that the treatment groups were effective in reducing edema when compared to the control. The HFB had the highest edema volume reduction after 21 days of treatment. The treatment groups did not induce tissue necrosis or infections on the histopathological analysis. Tenocyte proliferation, granulation tissue, and collagen formation were observed in the PTCT area in the HFB and HFB + PBM groups, which culminated a better repair process when compared to the CG in the 3 experimental periods. Interestingly, the PBM group revealed, in histological analysis, major tendon injury after 7 days; however, in the periods of 14 and 21 days, the PBM had a better repair process compared to the CG. In the quantification of collagen, there was no statistical difference between the groups in the 3 experimental periods. The findings suggest that the HFB and PBM treatments, isolated or associated, were effective in reducing the volume of the edema, stimulating the repair process. However, the use of HFB alone was more effective in promoting the tendon repair process. Thus, the present study consolidates previous studies of tendon repair with this new HFB. Future clinical trials will be needed to validate this proposal.Department of Biomedical Engineering Instituto Científico E Tecnológico University BrazilBiotechnology and Biodiversity Research Center UESPICenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP – Univ Estadual Paulista)Department of Physiotherapy Federal University of São CarlosDepartment of Health Sciences Piauí State University (UESPI)Department of Physiotherapy, Faculdade UninovafapiCenter for the Study of Venoms and Venomous Animals (CEVAP) São Paulo State University (UNESP – Univ Estadual Paulista)University BrazilUESPIUniversidade Estadual Paulista (Unesp)Universidade Federal de São Carlos (UFSCar)Piauí State University (UESPI)de Freitas Dutra Júnior, EnéasHidd, Sílvia Maria Cardoso MagalhãesAmaral, Marcello MagriFilho, Antonio Luiz Martins MaiaAssis, LiviaFerreira, Rui Seabra [UNESP]Barraviera, Benedito [UNESP]Martignago, Cintia Cristina SantiFigueredo-Silva, Joséde Oliveira, Rauirys AlencarTim, Carla Roberta2021-06-25T11:00:45Z2021-06-25T11:00:45Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s10103-021-03341-xLasers in Medical Science.1435-604X0268-8921http://hdl.handle.net/11449/20777310.1007/s10103-021-03341-x2-s2.0-85106475185Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLasers in Medical Scienceinfo:eu-repo/semantics/openAccess2024-04-11T15:28:26Zoai:repositorio.unesp.br:11449/207773Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:58:02.892794Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats |
title |
Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats |
spellingShingle |
Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats de Freitas Dutra Júnior, Enéas Calcaneus tendon Heterologous fibrin biopolymer Photobiomodulation Rats Tissue repair |
title_short |
Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats |
title_full |
Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats |
title_fullStr |
Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats |
title_full_unstemmed |
Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats |
title_sort |
Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats |
author |
de Freitas Dutra Júnior, Enéas |
author_facet |
de Freitas Dutra Júnior, Enéas Hidd, Sílvia Maria Cardoso Magalhães Amaral, Marcello Magri Filho, Antonio Luiz Martins Maia Assis, Livia Ferreira, Rui Seabra [UNESP] Barraviera, Benedito [UNESP] Martignago, Cintia Cristina Santi Figueredo-Silva, José de Oliveira, Rauirys Alencar Tim, Carla Roberta |
author_role |
author |
author2 |
Hidd, Sílvia Maria Cardoso Magalhães Amaral, Marcello Magri Filho, Antonio Luiz Martins Maia Assis, Livia Ferreira, Rui Seabra [UNESP] Barraviera, Benedito [UNESP] Martignago, Cintia Cristina Santi Figueredo-Silva, José de Oliveira, Rauirys Alencar Tim, Carla Roberta |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
University Brazil UESPI Universidade Estadual Paulista (Unesp) Universidade Federal de São Carlos (UFSCar) Piauí State University (UESPI) |
dc.contributor.author.fl_str_mv |
de Freitas Dutra Júnior, Enéas Hidd, Sílvia Maria Cardoso Magalhães Amaral, Marcello Magri Filho, Antonio Luiz Martins Maia Assis, Livia Ferreira, Rui Seabra [UNESP] Barraviera, Benedito [UNESP] Martignago, Cintia Cristina Santi Figueredo-Silva, José de Oliveira, Rauirys Alencar Tim, Carla Roberta |
dc.subject.por.fl_str_mv |
Calcaneus tendon Heterologous fibrin biopolymer Photobiomodulation Rats Tissue repair |
topic |
Calcaneus tendon Heterologous fibrin biopolymer Photobiomodulation Rats Tissue repair |
description |
The present study aimed to evaluate the new heterologous fibrin biopolymer associated, or not, with photobiomodulation therapy for application in tendon injuries, considered a serious and common orthopedic problem. Thus, 84 Rattus norvegicus had partial transection of the calcaneus tendon (PTCT) and were randomly divided into: control (CG); heterologous fibrin biopolymer (HFB); photobiomodulation (PBM); heterologous fibrin biopolymer + photobiomodulation (HFB + PBM). The animals received HFB immediately after PTCT, while PBM (660 nm, 40 mW, 0.23 J) started 24 h post injury and followed every 24 h for 7, 14, and 21 days. The results of the edema volume showed that after 24 h of PTCT, there was no statistical difference among the groups. After 7, 14, and 21 days, it was observed that the treatment groups were effective in reducing edema when compared to the control. The HFB had the highest edema volume reduction after 21 days of treatment. The treatment groups did not induce tissue necrosis or infections on the histopathological analysis. Tenocyte proliferation, granulation tissue, and collagen formation were observed in the PTCT area in the HFB and HFB + PBM groups, which culminated a better repair process when compared to the CG in the 3 experimental periods. Interestingly, the PBM group revealed, in histological analysis, major tendon injury after 7 days; however, in the periods of 14 and 21 days, the PBM had a better repair process compared to the CG. In the quantification of collagen, there was no statistical difference between the groups in the 3 experimental periods. The findings suggest that the HFB and PBM treatments, isolated or associated, were effective in reducing the volume of the edema, stimulating the repair process. However, the use of HFB alone was more effective in promoting the tendon repair process. Thus, the present study consolidates previous studies of tendon repair with this new HFB. Future clinical trials will be needed to validate this proposal. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:00:45Z 2021-06-25T11:00:45Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10103-021-03341-x Lasers in Medical Science. 1435-604X 0268-8921 http://hdl.handle.net/11449/207773 10.1007/s10103-021-03341-x 2-s2.0-85106475185 |
url |
http://dx.doi.org/10.1007/s10103-021-03341-x http://hdl.handle.net/11449/207773 |
identifier_str_mv |
Lasers in Medical Science. 1435-604X 0268-8921 10.1007/s10103-021-03341-x 2-s2.0-85106475185 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lasers in Medical Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129269007646720 |