Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1472-6882-11-133 http://hdl.handle.net/11449/10761 |
Resumo: | Background: Exercise stress was shown to increase oxidative stress in rats. It lacks reports of increased protection afforded by dietary antioxidant supplements against ROS production during exercise stress. We evaluated the effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress.Methods: Wistar rats were divided into three groups: 1) control group; 2) exercise stress group and; 3) exercise stress + Vitamin E group. Rats from the group 3 were treated with gavage administration of 1 mL of Vitamin E (5 mg/kg) for seven consecutive days. Animals from groups 2 and 3 were submitted to a bout of swimming exhaustive exercise stress. Kidney samples were analyzed for Thiobarbituric Acid Reactive Substances to (TBARS) by malondialdehyde (MDA), reduced glutathione (GSH) and vitamin-E levels.Results: The group treated with vitamin E and submitted to exercise stress presented the lowest levels of renal MDA (1: 0.16+0.02 mmmol/mgprot vs. 2: 0.34+0.07 mmmol/mgprot vs. 3: 0.1+0.01 mmmol/mgprot; p < 0.0001), the highest levels of renal GSH (1: 23+4 mu mol/gprot vs. 2: 23+2 mu mol/gprot vs. 3: 58+9 mu mol/gprot; p < 0.0001) and the highest levels of renal vitamin E (1: 24+6 mu M/gtissue vs. 2: 28+2 mu M/gtissue vs. 3: 43+4 mu M/gtissue; p < 0.001).Conclusion: Vitamin E supplementation improved non-enzymatic antioxidant activity in young rats submitted to exhaustive exercise stress. |
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Repositório Institucional da UNESP |
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Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stressBackground: Exercise stress was shown to increase oxidative stress in rats. It lacks reports of increased protection afforded by dietary antioxidant supplements against ROS production during exercise stress. We evaluated the effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress.Methods: Wistar rats were divided into three groups: 1) control group; 2) exercise stress group and; 3) exercise stress + Vitamin E group. Rats from the group 3 were treated with gavage administration of 1 mL of Vitamin E (5 mg/kg) for seven consecutive days. Animals from groups 2 and 3 were submitted to a bout of swimming exhaustive exercise stress. Kidney samples were analyzed for Thiobarbituric Acid Reactive Substances to (TBARS) by malondialdehyde (MDA), reduced glutathione (GSH) and vitamin-E levels.Results: The group treated with vitamin E and submitted to exercise stress presented the lowest levels of renal MDA (1: 0.16+0.02 mmmol/mgprot vs. 2: 0.34+0.07 mmmol/mgprot vs. 3: 0.1+0.01 mmmol/mgprot; p < 0.0001), the highest levels of renal GSH (1: 23+4 mu mol/gprot vs. 2: 23+2 mu mol/gprot vs. 3: 58+9 mu mol/gprot; p < 0.0001) and the highest levels of renal vitamin E (1: 24+6 mu M/gtissue vs. 2: 28+2 mu M/gtissue vs. 3: 43+4 mu M/gtissue; p < 0.001).Conclusion: Vitamin E supplementation improved non-enzymatic antioxidant activity in young rats submitted to exhaustive exercise stress.Departamento de Clinica Médica da Faculdade de Medicina de Ribeirao Preto da Universidade de São Paulo (USP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ São Paulo, Lab Quim & Bioquim Alimentos, São Paulo, BrazilFac Med ABC, Dept Morfol & Fisiol, Santo Andre, SP, BrazilUniv Estadual Paulista, UNESP, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, BrazilUniv São Paulo, Fac Saúde Publ, Dept Saúde Materno Infantil, São Paulo, BrazilUniv Estadual Paulista, UNESP, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, BrazilBiomed Central Ltd.Universidade de São Paulo (USP)Fac Med ABCUniversidade Estadual Paulista (Unesp)Bucioli, Servio A.Abreu, Luiz Carlos de [UNESP]Valenti, Vitor Engrácia [UNESP]Leone, ClaudioVannucchi, Helio2014-05-20T13:31:35Z2014-05-20T13:31:35Z2011-12-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://dx.doi.org/10.1186/1472-6882-11-133Bmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 11, p. 6, 2011.1472-6882http://hdl.handle.net/11449/1076110.1186/1472-6882-11-133WOS:000301887400001WOS000301887400001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBMC Complementary and Alternative Medicine2.1090,858info:eu-repo/semantics/openAccess2024-08-09T17:40:17Zoai:repositorio.unesp.br:11449/10761Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-09T17:40:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress |
title |
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress |
spellingShingle |
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress Bucioli, Servio A. |
title_short |
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress |
title_full |
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress |
title_fullStr |
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress |
title_full_unstemmed |
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress |
title_sort |
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress |
author |
Bucioli, Servio A. |
author_facet |
Bucioli, Servio A. Abreu, Luiz Carlos de [UNESP] Valenti, Vitor Engrácia [UNESP] Leone, Claudio Vannucchi, Helio |
author_role |
author |
author2 |
Abreu, Luiz Carlos de [UNESP] Valenti, Vitor Engrácia [UNESP] Leone, Claudio Vannucchi, Helio |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Fac Med ABC Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Bucioli, Servio A. Abreu, Luiz Carlos de [UNESP] Valenti, Vitor Engrácia [UNESP] Leone, Claudio Vannucchi, Helio |
description |
Background: Exercise stress was shown to increase oxidative stress in rats. It lacks reports of increased protection afforded by dietary antioxidant supplements against ROS production during exercise stress. We evaluated the effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress.Methods: Wistar rats were divided into three groups: 1) control group; 2) exercise stress group and; 3) exercise stress + Vitamin E group. Rats from the group 3 were treated with gavage administration of 1 mL of Vitamin E (5 mg/kg) for seven consecutive days. Animals from groups 2 and 3 were submitted to a bout of swimming exhaustive exercise stress. Kidney samples were analyzed for Thiobarbituric Acid Reactive Substances to (TBARS) by malondialdehyde (MDA), reduced glutathione (GSH) and vitamin-E levels.Results: The group treated with vitamin E and submitted to exercise stress presented the lowest levels of renal MDA (1: 0.16+0.02 mmmol/mgprot vs. 2: 0.34+0.07 mmmol/mgprot vs. 3: 0.1+0.01 mmmol/mgprot; p < 0.0001), the highest levels of renal GSH (1: 23+4 mu mol/gprot vs. 2: 23+2 mu mol/gprot vs. 3: 58+9 mu mol/gprot; p < 0.0001) and the highest levels of renal vitamin E (1: 24+6 mu M/gtissue vs. 2: 28+2 mu M/gtissue vs. 3: 43+4 mu M/gtissue; p < 0.001).Conclusion: Vitamin E supplementation improved non-enzymatic antioxidant activity in young rats submitted to exhaustive exercise stress. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-20 2014-05-20T13:31:35Z 2014-05-20T13:31:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1472-6882-11-133 Bmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 11, p. 6, 2011. 1472-6882 http://hdl.handle.net/11449/10761 10.1186/1472-6882-11-133 WOS:000301887400001 WOS000301887400001.pdf |
url |
http://dx.doi.org/10.1186/1472-6882-11-133 http://hdl.handle.net/11449/10761 |
identifier_str_mv |
Bmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 11, p. 6, 2011. 1472-6882 10.1186/1472-6882-11-133 WOS:000301887400001 WOS000301887400001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMC Complementary and Alternative Medicine 2.109 0,858 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128208431742976 |