Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogram
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-91992007000400010 http://hdl.handle.net/11449/70081 |
Resumo: | The present study aimed at evaluating clinical and laboratory aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with antiophidic serum. Twenty-one dogs were divided into three groups of seven animals each. Group I received 1mg/kg venom (sc); Group II received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution (iv); and Group III received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution containing sodium bicarbonate diluted to the dose of 4mEq/kg. The clinical signs of ataxia, sedation, flaccid paralysis, mydriasis, eyeball paralysis, mandible ptosis, sialorrhea, vomiting and diarrhea observed in the dogs were very similar to those observed in humans. The decrease in hemoglobin, hematocrit, erythrocyte, platelet and fibrinogen levels, prolongation of clotting time, prothrombin time (PT) and activated partial thromboplastin time (APTT), as well as hypocellularity in the bone marrow characterized anemia, thrombocytopenia and blood incoagulability, as well as hypofibrinogenemia and decreased bone-marrow activity. Important bleeding was not observed. Increased numbers of leukocytes and neutrophils and decreased numbers of lymphocytes and eosinophils characterized an acute inflammatory response and stress caused by generalized pain. The employed antiophidic serum was effective and all animals survived. |
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Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogramClinical aspectsCrotalus durissus terrificusDogsLaboratory aspectsAnimaliaCanis familiarisThe present study aimed at evaluating clinical and laboratory aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with antiophidic serum. Twenty-one dogs were divided into three groups of seven animals each. Group I received 1mg/kg venom (sc); Group II received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution (iv); and Group III received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution containing sodium bicarbonate diluted to the dose of 4mEq/kg. The clinical signs of ataxia, sedation, flaccid paralysis, mydriasis, eyeball paralysis, mandible ptosis, sialorrhea, vomiting and diarrhea observed in the dogs were very similar to those observed in humans. The decrease in hemoglobin, hematocrit, erythrocyte, platelet and fibrinogen levels, prolongation of clotting time, prothrombin time (PT) and activated partial thromboplastin time (APTT), as well as hypocellularity in the bone marrow characterized anemia, thrombocytopenia and blood incoagulability, as well as hypofibrinogenemia and decreased bone-marrow activity. Important bleeding was not observed. Increased numbers of leukocytes and neutrophils and decreased numbers of lymphocytes and eosinophils characterized an acute inflammatory response and stress caused by generalized pain. The employed antiophidic serum was effective and all animals survived.Department of Small Animals Medical Clinic University of Western São Paulo, Presidente Prudente, São Paulo StateDepartment of Small Animals School of Veterinary Medicine and Animal Husbandry São Paulo State University, Botucatu, São Paulo StateDepartment of Clinical Pathology UNOESTE, Presidente Prudente, São Paulo State, Rua Santo Brugnoli, 249, 19025-160, Presidente Prudente, São PauloDepartment of Small Animals School of Veterinary Medicine and Animal Husbandry São Paulo State University, Botucatu, São Paulo StateUniversity of Western São PauloUniversidade Estadual Paulista (Unesp)Universidade do Oeste Paulista (UNOESTE)Nogueira, Rosa Maria BarilliSakate, M. [UNESP]Sangiorgio, F.Laposy, C. B.Melero, M.2014-05-27T11:22:41Z2014-05-27T11:22:41Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article800-810application/pdfhttp://dx.doi.org/10.1590/S1678-91992007000400010Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 800-810, 2007.1678-9199http://hdl.handle.net/11449/7008110.1590/S1678-91992007000400010S1678-91992007000400010WOS:0002513252000102-s2.0-383491176922-s2.0-38349117692.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseases1.7820,573info:eu-repo/semantics/openAccess2023-12-30T06:14:23Zoai:repositorio.unesp.br:11449/70081Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-30T06:14:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogram |
title |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogram |
spellingShingle |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogram Nogueira, Rosa Maria Barilli Clinical aspects Crotalus durissus terrificus Dogs Laboratory aspects Animalia Canis familiaris |
title_short |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogram |
title_full |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogram |
title_fullStr |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogram |
title_full_unstemmed |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogram |
title_sort |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - Part I: Clinical evaluation, hematology and myelogram |
author |
Nogueira, Rosa Maria Barilli |
author_facet |
Nogueira, Rosa Maria Barilli Sakate, M. [UNESP] Sangiorgio, F. Laposy, C. B. Melero, M. |
author_role |
author |
author2 |
Sakate, M. [UNESP] Sangiorgio, F. Laposy, C. B. Melero, M. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
University of Western São Paulo Universidade Estadual Paulista (Unesp) Universidade do Oeste Paulista (UNOESTE) |
dc.contributor.author.fl_str_mv |
Nogueira, Rosa Maria Barilli Sakate, M. [UNESP] Sangiorgio, F. Laposy, C. B. Melero, M. |
dc.subject.por.fl_str_mv |
Clinical aspects Crotalus durissus terrificus Dogs Laboratory aspects Animalia Canis familiaris |
topic |
Clinical aspects Crotalus durissus terrificus Dogs Laboratory aspects Animalia Canis familiaris |
description |
The present study aimed at evaluating clinical and laboratory aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with antiophidic serum. Twenty-one dogs were divided into three groups of seven animals each. Group I received 1mg/kg venom (sc); Group II received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution (iv); and Group III received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution containing sodium bicarbonate diluted to the dose of 4mEq/kg. The clinical signs of ataxia, sedation, flaccid paralysis, mydriasis, eyeball paralysis, mandible ptosis, sialorrhea, vomiting and diarrhea observed in the dogs were very similar to those observed in humans. The decrease in hemoglobin, hematocrit, erythrocyte, platelet and fibrinogen levels, prolongation of clotting time, prothrombin time (PT) and activated partial thromboplastin time (APTT), as well as hypocellularity in the bone marrow characterized anemia, thrombocytopenia and blood incoagulability, as well as hypofibrinogenemia and decreased bone-marrow activity. Important bleeding was not observed. Increased numbers of leukocytes and neutrophils and decreased numbers of lymphocytes and eosinophils characterized an acute inflammatory response and stress caused by generalized pain. The employed antiophidic serum was effective and all animals survived. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 2014-05-27T11:22:41Z 2014-05-27T11:22:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-91992007000400010 Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 800-810, 2007. 1678-9199 http://hdl.handle.net/11449/70081 10.1590/S1678-91992007000400010 S1678-91992007000400010 WOS:000251325200010 2-s2.0-38349117692 2-s2.0-38349117692.pdf |
url |
http://dx.doi.org/10.1590/S1678-91992007000400010 http://hdl.handle.net/11449/70081 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 13, n. 4, p. 800-810, 2007. 1678-9199 10.1590/S1678-91992007000400010 S1678-91992007000400010 WOS:000251325200010 2-s2.0-38349117692 2-s2.0-38349117692.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases 1.782 0,573 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
800-810 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965451339431936 |