Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.6061/clinics/2019/e929 http://hdl.handle.net/11449/187764 |
Resumo: | OBJECTIVE: Hematopoietic stem-cell transplantation (HSCT) childhood survivors of hematologic malignancies are prone to develop late osteopenia and osteoporosis. The purpose of this retrospective study was to quantitatively and qualitatively assess bone mineral density (BMD) in HSCT childhood survivors and to compare the effectiveness of both qualitative and quantitative assessment methods. METHODS: DESIGN BMD assessment using panoramic radiographs of childhood HSCT survivors aged 3.69-18.88 years using two radiomorphometric indexes. Case-control double-blinded comparison of panoramic radiographic images from childhood HSCT survivors and age- and sex-matched healthy controls. Quantitative assessment was performed by measuring the cortical bone width bilaterally at the mental foramen level. Qualitative assessment was performed using the mandibular cortical index bilaterally on all panoramic images. RESULTS: Radiographs were taken 6.59-83.95 months after bone marrow transplantation [median±SD=25.92 ±24.9 months]. Fifty-two panoramic radiographic images were analyzed: 21 from HSCT survivors and 31 from healthy controls aged 3.69-25.1 years [mean±SD=11.89±5.28 years]. The mandibular cortical bone width was 17% smaller in childhood HSCT survivors than in healthy controls (case group: 2.420, control group: 3.307; p=0.00617). Qualitative analysis revealed an increased frequency of severe mandibular cortical erosion in childhood HSCT survivors, although no significant difference was observed (case group: 1.540, control group: 1.490; p=0.32). The interobserver agreement was 85% (Kappa index). CONCLUSIONS: HSCT childhood survivors exhibit quantitative and qualitative mandibular bone impairments. Further studies are needed to establish an association between mandibular cortical bone impairment and osteoporosis. |
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Repositório Institucional da UNESP |
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Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantationBone Marrow TransplantationChildrenHematopoietic Stem Cell TransplantationOsteoporosisRadiomorphometric AssessmentOBJECTIVE: Hematopoietic stem-cell transplantation (HSCT) childhood survivors of hematologic malignancies are prone to develop late osteopenia and osteoporosis. The purpose of this retrospective study was to quantitatively and qualitatively assess bone mineral density (BMD) in HSCT childhood survivors and to compare the effectiveness of both qualitative and quantitative assessment methods. METHODS: DESIGN BMD assessment using panoramic radiographs of childhood HSCT survivors aged 3.69-18.88 years using two radiomorphometric indexes. Case-control double-blinded comparison of panoramic radiographic images from childhood HSCT survivors and age- and sex-matched healthy controls. Quantitative assessment was performed by measuring the cortical bone width bilaterally at the mental foramen level. Qualitative assessment was performed using the mandibular cortical index bilaterally on all panoramic images. RESULTS: Radiographs were taken 6.59-83.95 months after bone marrow transplantation [median±SD=25.92 ±24.9 months]. Fifty-two panoramic radiographic images were analyzed: 21 from HSCT survivors and 31 from healthy controls aged 3.69-25.1 years [mean±SD=11.89±5.28 years]. The mandibular cortical bone width was 17% smaller in childhood HSCT survivors than in healthy controls (case group: 2.420, control group: 3.307; p=0.00617). Qualitative analysis revealed an increased frequency of severe mandibular cortical erosion in childhood HSCT survivors, although no significant difference was observed (case group: 1.540, control group: 1.490; p=0.32). The interobserver agreement was 85% (Kappa index). CONCLUSIONS: HSCT childhood survivors exhibit quantitative and qualitative mandibular bone impairments. Further studies are needed to establish an association between mandibular cortical bone impairment and osteoporosis.Departamento de Pediatria Faculdade de Medicina FMUSP Universidade de Sao PauloDepartamento de Estomatologia Faculdade de Odontologia Universidade de Sao PauloDepartamento de Saude Faculdade de Odontologia Universidade Nove de JulhoFaculdade de Odontologia Universidade Estadual Paulista (UNESP)Faculdade de Odontologia Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Universidade Nove de JulhoUniversidade Estadual Paulista (Unesp)Frascino, Alexandre VianaCosta, ClaudioSalgado, Daniela Miranda Richarte de AndradeCoracin, Fabio LuizFava, Marcelo [UNESP]Odone-Filho, Vicente2019-10-06T15:46:30Z2019-10-06T15:46:30Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.6061/clinics/2019/e929Clinics, v. 74.1807-5932http://hdl.handle.net/11449/18776410.6061/clinics/2019/e929S1807-593220190001002312-s2.0-85067442051S1807-59322019000100231.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinicsinfo:eu-repo/semantics/openAccess2023-10-20T06:04:21Zoai:repositorio.unesp.br:11449/187764Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:24:05.481774Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation |
title |
Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation |
spellingShingle |
Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation Frascino, Alexandre Viana Bone Marrow Transplantation Children Hematopoietic Stem Cell Transplantation Osteoporosis Radiomorphometric Assessment |
title_short |
Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation |
title_full |
Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation |
title_fullStr |
Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation |
title_full_unstemmed |
Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation |
title_sort |
Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation |
author |
Frascino, Alexandre Viana |
author_facet |
Frascino, Alexandre Viana Costa, Claudio Salgado, Daniela Miranda Richarte de Andrade Coracin, Fabio Luiz Fava, Marcelo [UNESP] Odone-Filho, Vicente |
author_role |
author |
author2 |
Costa, Claudio Salgado, Daniela Miranda Richarte de Andrade Coracin, Fabio Luiz Fava, Marcelo [UNESP] Odone-Filho, Vicente |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Nove de Julho Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Frascino, Alexandre Viana Costa, Claudio Salgado, Daniela Miranda Richarte de Andrade Coracin, Fabio Luiz Fava, Marcelo [UNESP] Odone-Filho, Vicente |
dc.subject.por.fl_str_mv |
Bone Marrow Transplantation Children Hematopoietic Stem Cell Transplantation Osteoporosis Radiomorphometric Assessment |
topic |
Bone Marrow Transplantation Children Hematopoietic Stem Cell Transplantation Osteoporosis Radiomorphometric Assessment |
description |
OBJECTIVE: Hematopoietic stem-cell transplantation (HSCT) childhood survivors of hematologic malignancies are prone to develop late osteopenia and osteoporosis. The purpose of this retrospective study was to quantitatively and qualitatively assess bone mineral density (BMD) in HSCT childhood survivors and to compare the effectiveness of both qualitative and quantitative assessment methods. METHODS: DESIGN BMD assessment using panoramic radiographs of childhood HSCT survivors aged 3.69-18.88 years using two radiomorphometric indexes. Case-control double-blinded comparison of panoramic radiographic images from childhood HSCT survivors and age- and sex-matched healthy controls. Quantitative assessment was performed by measuring the cortical bone width bilaterally at the mental foramen level. Qualitative assessment was performed using the mandibular cortical index bilaterally on all panoramic images. RESULTS: Radiographs were taken 6.59-83.95 months after bone marrow transplantation [median±SD=25.92 ±24.9 months]. Fifty-two panoramic radiographic images were analyzed: 21 from HSCT survivors and 31 from healthy controls aged 3.69-25.1 years [mean±SD=11.89±5.28 years]. The mandibular cortical bone width was 17% smaller in childhood HSCT survivors than in healthy controls (case group: 2.420, control group: 3.307; p=0.00617). Qualitative analysis revealed an increased frequency of severe mandibular cortical erosion in childhood HSCT survivors, although no significant difference was observed (case group: 1.540, control group: 1.490; p=0.32). The interobserver agreement was 85% (Kappa index). CONCLUSIONS: HSCT childhood survivors exhibit quantitative and qualitative mandibular bone impairments. Further studies are needed to establish an association between mandibular cortical bone impairment and osteoporosis. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T15:46:30Z 2019-10-06T15:46:30Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.6061/clinics/2019/e929 Clinics, v. 74. 1807-5932 http://hdl.handle.net/11449/187764 10.6061/clinics/2019/e929 S1807-59322019000100231 2-s2.0-85067442051 S1807-59322019000100231.pdf |
url |
http://dx.doi.org/10.6061/clinics/2019/e929 http://hdl.handle.net/11449/187764 |
identifier_str_mv |
Clinics, v. 74. 1807-5932 10.6061/clinics/2019/e929 S1807-59322019000100231 2-s2.0-85067442051 S1807-59322019000100231.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128508587671552 |