New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1159/000479350 http://hdl.handle.net/11449/176518 |
Resumo: | The limited effect of fluoride on root caries has prompted the study of new preventive therapies, which involve recently developed functional peptides, lasers, phosphate-based technologies, among several other approaches. Most of the specific peptides currently investigated have been developed based on the available information related to the protective action of salivary proteins, including statherin-derived peptides. Other peptides include 8DSS, self-assembling peptide P11-4, antimicrobial peptides, and casein phosphopeptides combined with amorphous calcium phosphate. These were shown to increase remineralization and/or to protect against demineralization through different mechanisms, including the attraction of calcium ions to the demineralized tissue, delivery of available calcium, and antimicrobial action. Regarding phosphate-based technologies, the addition of polyphosphate salts to fluoridated vehicles has been shown to promote a synergistic effect in promoting enamel remineralization and in preventing demineralization, in studies with in vitro, in situ, and clinical protocols. Sodium trimetaphosphate has also been shown to promote intrafibrillar collagen remineralization, phosphate uptake by previously demineralized dentin, and deposition of needle-like crystallites at intrafibrillar level. As for the use of lasers, their effects on the mineral content and crystallinity of dentin were shown to be related to the removal of water and protein, besides surface melting by thermal degradation. Lasers have also been shown to have synergistic/additive effects with fluoride on the prevention of root dentin demineralization, due to the enhanced fluoride uptake and the decreased calcium and phosphate loss. Although the above-mentioned therapies seem to be promising alternatives to prevent root caries, clinical evidence is still required. |
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New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth DemineralizationThe limited effect of fluoride on root caries has prompted the study of new preventive therapies, which involve recently developed functional peptides, lasers, phosphate-based technologies, among several other approaches. Most of the specific peptides currently investigated have been developed based on the available information related to the protective action of salivary proteins, including statherin-derived peptides. Other peptides include 8DSS, self-assembling peptide P11-4, antimicrobial peptides, and casein phosphopeptides combined with amorphous calcium phosphate. These were shown to increase remineralization and/or to protect against demineralization through different mechanisms, including the attraction of calcium ions to the demineralized tissue, delivery of available calcium, and antimicrobial action. Regarding phosphate-based technologies, the addition of polyphosphate salts to fluoridated vehicles has been shown to promote a synergistic effect in promoting enamel remineralization and in preventing demineralization, in studies with in vitro, in situ, and clinical protocols. Sodium trimetaphosphate has also been shown to promote intrafibrillar collagen remineralization, phosphate uptake by previously demineralized dentin, and deposition of needle-like crystallites at intrafibrillar level. As for the use of lasers, their effects on the mineral content and crystallinity of dentin were shown to be related to the removal of water and protein, besides surface melting by thermal degradation. Lasers have also been shown to have synergistic/additive effects with fluoride on the prevention of root dentin demineralization, due to the enhanced fluoride uptake and the decreased calcium and phosphate loss. Although the above-mentioned therapies seem to be promising alternatives to prevent root caries, clinical evidence is still required.Department of Biological Sciences Bauru School of Dentistry University of São Paulo, Al. Octávio Pinheiro Brisolla, 9-75Department of Pediatric Dentistry and Public Health School of Dentistry Araçatuba São Paulo State University (Unesp), Rua José Bonifácio, 1193Department of Pediatric Dentistry and Public Health School of Dentistry Araçatuba São Paulo State University (Unesp), Rua José Bonifácio, 1193Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Buzalaf, Marília Afonso RabeloPessan, Juliano Pelim [UNESP]2018-12-11T17:21:11Z2018-12-11T17:21:11Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article88-96http://dx.doi.org/10.1159/000479350Monographs in Oral Science, v. 26, p. 88-96.1662-38430077-0892http://hdl.handle.net/11449/17651810.1159/0004793502-s2.0-85049189641Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMonographs in Oral Science2,017info:eu-repo/semantics/openAccess2021-10-23T17:30:11Zoai:repositorio.unesp.br:11449/176518Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:38:36.478566Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization |
title |
New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization |
spellingShingle |
New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization Buzalaf, Marília Afonso Rabelo |
title_short |
New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization |
title_full |
New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization |
title_fullStr |
New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization |
title_full_unstemmed |
New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization |
title_sort |
New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization |
author |
Buzalaf, Marília Afonso Rabelo |
author_facet |
Buzalaf, Marília Afonso Rabelo Pessan, Juliano Pelim [UNESP] |
author_role |
author |
author2 |
Pessan, Juliano Pelim [UNESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Buzalaf, Marília Afonso Rabelo Pessan, Juliano Pelim [UNESP] |
description |
The limited effect of fluoride on root caries has prompted the study of new preventive therapies, which involve recently developed functional peptides, lasers, phosphate-based technologies, among several other approaches. Most of the specific peptides currently investigated have been developed based on the available information related to the protective action of salivary proteins, including statherin-derived peptides. Other peptides include 8DSS, self-assembling peptide P11-4, antimicrobial peptides, and casein phosphopeptides combined with amorphous calcium phosphate. These were shown to increase remineralization and/or to protect against demineralization through different mechanisms, including the attraction of calcium ions to the demineralized tissue, delivery of available calcium, and antimicrobial action. Regarding phosphate-based technologies, the addition of polyphosphate salts to fluoridated vehicles has been shown to promote a synergistic effect in promoting enamel remineralization and in preventing demineralization, in studies with in vitro, in situ, and clinical protocols. Sodium trimetaphosphate has also been shown to promote intrafibrillar collagen remineralization, phosphate uptake by previously demineralized dentin, and deposition of needle-like crystallites at intrafibrillar level. As for the use of lasers, their effects on the mineral content and crystallinity of dentin were shown to be related to the removal of water and protein, besides surface melting by thermal degradation. Lasers have also been shown to have synergistic/additive effects with fluoride on the prevention of root dentin demineralization, due to the enhanced fluoride uptake and the decreased calcium and phosphate loss. Although the above-mentioned therapies seem to be promising alternatives to prevent root caries, clinical evidence is still required. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2018-12-11T17:21:11Z 2018-12-11T17:21:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1159/000479350 Monographs in Oral Science, v. 26, p. 88-96. 1662-3843 0077-0892 http://hdl.handle.net/11449/176518 10.1159/000479350 2-s2.0-85049189641 |
url |
http://dx.doi.org/10.1159/000479350 http://hdl.handle.net/11449/176518 |
identifier_str_mv |
Monographs in Oral Science, v. 26, p. 88-96. 1662-3843 0077-0892 10.1159/000479350 2-s2.0-85049189641 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Monographs in Oral Science 2,017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
88-96 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129231078555648 |