Maternal care of the whole litter improves the success rate of diabetes in pregnancy in rats

• Autor(a) principal: Floriano, Juliana Ferreira [UNESP]
• Data de Publicação: 2022
• Outros Autores: Barbosa, Angélica Mércia Pascon [UNESP], de Oliveira, Rafael Guilen [UNESP], Vega, Sofía [UNESP], Catinelli, Bruna Bologna [UNESP], Garcia, Gabriela Azevedo [UNESP], Reyes, David Rafael [UNESP], Sobrevia, Luis [UNESP], Rudge, Marilza Vieira Cunha [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.placenta.2022.11.002; http://hdl.handle.net/11449/249347

Induction of diabetes mellitus by streptozotocin (STZ) in rats at birth is of high mortality and low success rate when male puppies are separated from females, prioritizing females breastfeeding. Cross-parental care of the entire litter and SZT-induced diabetes up to 12 h post-birth become with high success rate, low animal death, and females with glycaemia >140 mg/dL on the 90 postnatal day. Cross-parental care is more effective in STZ-induction of diabetes, which is maintained during pregnancy (diabetes in pregnancy), than the conventional protocol of male separation at birth.