An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs

Detalhes bibliográficos
Autor(a) principal: Palmieri, Chiara
Data de Publicação: 2019
Outros Autores: Hood, Grace, Fonseca-Alves, Carlos Eduardo [UNESP], Laufer-Amorim, Renée [UNESP], Allavena, Rachel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.rvsc.2018.11.022
http://hdl.handle.net/11449/188440
Resumo: The aim of this study was to characterise T and B lymphocyte density in 6 normal prostates, 15 benign prostatic hyperplasia (BPH) and 24 prostate carcinomas (PCs) in dogs by immunohistochemistry. Results revealed a statistically significant increase of T and B cells in PC compared to normal specimens and BPH. Regarding PC histological variants, lower number of CD3 + and CD79 + lymphocytes were observed in the most undifferentiated (solid) type. CD3 + cell density was positively correlated with survival time. These results may help in understanding the immunological mechanisms regulating BPH and PC development and progression, as well as providing background data for future immunotherapeutic trials.
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spelling An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogsCD3CD79DogsImmunohistochemistryLymphocytesProstate cancerThe aim of this study was to characterise T and B lymphocyte density in 6 normal prostates, 15 benign prostatic hyperplasia (BPH) and 24 prostate carcinomas (PCs) in dogs by immunohistochemistry. Results revealed a statistically significant increase of T and B cells in PC compared to normal specimens and BPH. Regarding PC histological variants, lower number of CD3 + and CD79 + lymphocytes were observed in the most undifferentiated (solid) type. CD3 + cell density was positively correlated with survival time. These results may help in understanding the immunological mechanisms regulating BPH and PC development and progression, as well as providing background data for future immunotherapeutic trials.School of Veterinary Science The University of Queensland, Gatton CampusDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science Univ. Estadual Paulista – UNESPDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science Univ. Estadual Paulista – UNESPThe University of QueenslandUniversidade Estadual Paulista (Unesp)Palmieri, ChiaraHood, GraceFonseca-Alves, Carlos Eduardo [UNESP]Laufer-Amorim, Renée [UNESP]Allavena, Rachel2019-10-06T16:08:07Z2019-10-06T16:08:07Z2019-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article189-192http://dx.doi.org/10.1016/j.rvsc.2018.11.022Research in Veterinary Science, v. 122, p. 189-192.1532-26610034-5288http://hdl.handle.net/11449/18844010.1016/j.rvsc.2018.11.0222-s2.0-85057628500Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengResearch in Veterinary Scienceinfo:eu-repo/semantics/openAccess2021-10-23T16:30:35Zoai:repositorio.unesp.br:11449/188440Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:29:40.479774Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs
title An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs
spellingShingle An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs
Palmieri, Chiara
CD3
CD79
Dogs
Immunohistochemistry
Lymphocytes
Prostate cancer
title_short An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs
title_full An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs
title_fullStr An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs
title_full_unstemmed An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs
title_sort An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs
author Palmieri, Chiara
author_facet Palmieri, Chiara
Hood, Grace
Fonseca-Alves, Carlos Eduardo [UNESP]
Laufer-Amorim, Renée [UNESP]
Allavena, Rachel
author_role author
author2 Hood, Grace
Fonseca-Alves, Carlos Eduardo [UNESP]
Laufer-Amorim, Renée [UNESP]
Allavena, Rachel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv The University of Queensland
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Palmieri, Chiara
Hood, Grace
Fonseca-Alves, Carlos Eduardo [UNESP]
Laufer-Amorim, Renée [UNESP]
Allavena, Rachel
dc.subject.por.fl_str_mv CD3
CD79
Dogs
Immunohistochemistry
Lymphocytes
Prostate cancer
topic CD3
CD79
Dogs
Immunohistochemistry
Lymphocytes
Prostate cancer
description The aim of this study was to characterise T and B lymphocyte density in 6 normal prostates, 15 benign prostatic hyperplasia (BPH) and 24 prostate carcinomas (PCs) in dogs by immunohistochemistry. Results revealed a statistically significant increase of T and B cells in PC compared to normal specimens and BPH. Regarding PC histological variants, lower number of CD3 + and CD79 + lymphocytes were observed in the most undifferentiated (solid) type. CD3 + cell density was positively correlated with survival time. These results may help in understanding the immunological mechanisms regulating BPH and PC development and progression, as well as providing background data for future immunotherapeutic trials.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:08:07Z
2019-10-06T16:08:07Z
2019-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.rvsc.2018.11.022
Research in Veterinary Science, v. 122, p. 189-192.
1532-2661
0034-5288
http://hdl.handle.net/11449/188440
10.1016/j.rvsc.2018.11.022
2-s2.0-85057628500
url http://dx.doi.org/10.1016/j.rvsc.2018.11.022
http://hdl.handle.net/11449/188440
identifier_str_mv Research in Veterinary Science, v. 122, p. 189-192.
1532-2661
0034-5288
10.1016/j.rvsc.2018.11.022
2-s2.0-85057628500
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Research in Veterinary Science
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 189-192
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128520212185088

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