Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity

Da Silva, Cristiana [UNESP]; Ribeiro, Leonardo B. [UNESP]; Furuno, Caio C. [UNESP]; Da Cunha, Gislaine A. [UNESP]; De Souza, Ronan F.F. [UNESP]; Netto, Adelino V.G. [UNESP]; Mauro, Antonio E. [UNESP]; Frem, Regina C.G. [UNESP]; Fernandes, José A.; Almeida Paz, Filipe A.; Marino, Leonardo B. [UNESP]; Pavan, Fernando R. [UNESP]; Leite, Clarice Q.F. [UNESP]

Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity

Detalhes bibliográficos
Autor(a) principal:	Da Silva, Cristiana [UNESP]
Data de Publicação:	2015
Outros Autores:	Ribeiro, Leonardo B. [UNESP], Furuno, Caio C. [UNESP], Da Cunha, Gislaine A. [UNESP], De Souza, Ronan F.F. [UNESP], Netto, Adelino V.G. [UNESP], Mauro, Antonio E. [UNESP], Frem, Regina C.G. [UNESP], Fernandes, José A., Almeida Paz, Filipe A., Marino, Leonardo B. [UNESP], Pavan, Fernando R. [UNESP], Leite, Clarice Q.F. [UNESP]
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da UNESP
Texto Completo:	http://dx.doi.org/10.1016/j.poly.2015.07.009 http://hdl.handle.net/11449/171978
Resumo:	Abstract Complexes of the type trans-[PdCl<inf>2</inf>(HL)(PPh<inf>3</inf>)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh<inf>3</inf> = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and <sup>1</sup>H NMR spectroscopies. Single-crystal X-ray diffraction determination on 3·0.9 CHCl<inf>3</inf> and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 ± 2.18 μM, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes.

Metadados do item

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spelling	Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activityMycobacterium tuberculosisPd(II) compoundsPyrazolesSpectroscopyTriphenylphosphineAbstract Complexes of the type trans-[PdCl<inf>2</inf>(HL)(PPh<inf>3</inf>)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh<inf>3</inf> = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and <sup>1</sup>H NMR spectroscopies. Single-crystal X-ray diffraction determination on 3·0.9 CHCl<inf>3</inf> and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 ± 2.18 μM, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP - Univ Estadual Paulista, P.O. Box 355Department of Chemistry, Campus Universitário de Santiago, University of AveiroDepartamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP - Univ Estadual Paulista, P.O. Box 502Departamento de Química Geral e Inorgânica, Instituto de Química de Araraquara, UNESP - Univ Estadual Paulista, P.O. Box 355Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP - Univ Estadual Paulista, P.O. Box 502FAPESP: 2012/15486-3FAPESP: PT2020FAPESP: SFRH/BPD/63736/2009Universidade Estadual Paulista (Unesp)Da Silva, Cristiana [UNESP]Ribeiro, Leonardo B. [UNESP]Furuno, Caio C. [UNESP]Da Cunha, Gislaine A. [UNESP]De Souza, Ronan F.F. [UNESP]Netto, Adelino V.G. [UNESP]Mauro, Antonio E. [UNESP]Frem, Regina C.G. [UNESP]Fernandes, José A.Almeida Paz, Filipe A.Marino, Leonardo B. [UNESP]Pavan, Fernando R. [UNESP]Leite, Clarice Q.F. [UNESP]2018-12-11T16:57:59Z2018-12-11T16:57:59Z2015-08-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10-16application/pdfhttp://dx.doi.org/10.1016/j.poly.2015.07.009Polyhedron, v. 100, p. 10-16.0277-5387http://hdl.handle.net/11449/17197810.1016/j.poly.2015.07.0092-s2.0-849385769732-s2.0-84938576973.pdf79276770536508190000-0002-0057-7964Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPolyhedron0,472info:eu-repo/semantics/openAccess2024-06-21T15:19:31Zoai:repositorio.unesp.br:11449/171978Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:59:57.879678Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv	Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity
title	Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity
spellingShingle	Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity Da Silva, Cristiana [UNESP] Mycobacterium tuberculosis Pd(II) compounds Pyrazoles Spectroscopy Triphenylphosphine
title_short	Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity
title_full	Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity
title_fullStr	Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity
title_full_unstemmed	Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity
title_sort	Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity
author	Da Silva, Cristiana [UNESP]
author_facet	Da Silva, Cristiana [UNESP] Ribeiro, Leonardo B. [UNESP] Furuno, Caio C. [UNESP] Da Cunha, Gislaine A. [UNESP] De Souza, Ronan F.F. [UNESP] Netto, Adelino V.G. [UNESP] Mauro, Antonio E. [UNESP] Frem, Regina C.G. [UNESP] Fernandes, José A. Almeida Paz, Filipe A. Marino, Leonardo B. [UNESP] Pavan, Fernando R. [UNESP] Leite, Clarice Q.F. [UNESP]
author_role	author
author2	Ribeiro, Leonardo B. [UNESP] Furuno, Caio C. [UNESP] Da Cunha, Gislaine A. [UNESP] De Souza, Ronan F.F. [UNESP] Netto, Adelino V.G. [UNESP] Mauro, Antonio E. [UNESP] Frem, Regina C.G. [UNESP] Fernandes, José A. Almeida Paz, Filipe A. Marino, Leonardo B. [UNESP] Pavan, Fernando R. [UNESP] Leite, Clarice Q.F. [UNESP]
author2_role	author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv	Da Silva, Cristiana [UNESP] Ribeiro, Leonardo B. [UNESP] Furuno, Caio C. [UNESP] Da Cunha, Gislaine A. [UNESP] De Souza, Ronan F.F. [UNESP] Netto, Adelino V.G. [UNESP] Mauro, Antonio E. [UNESP] Frem, Regina C.G. [UNESP] Fernandes, José A. Almeida Paz, Filipe A. Marino, Leonardo B. [UNESP] Pavan, Fernando R. [UNESP] Leite, Clarice Q.F. [UNESP]
dc.subject.por.fl_str_mv	Mycobacterium tuberculosis Pd(II) compounds Pyrazoles Spectroscopy Triphenylphosphine
topic	Mycobacterium tuberculosis Pd(II) compounds Pyrazoles Spectroscopy Triphenylphosphine
description	Abstract Complexes of the type trans-[PdCl<inf>2</inf>(HL)(PPh<inf>3</inf>)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh<inf>3</inf> = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and <sup>1</sup>H NMR spectroscopies. Single-crystal X-ray diffraction determination on 3·0.9 CHCl<inf>3</inf> and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 ± 2.18 μM, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes.
publishDate	2015
dc.date.none.fl_str_mv	2015-08-04 2018-12-11T16:57:59Z 2018-12-11T16:57:59Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://dx.doi.org/10.1016/j.poly.2015.07.009 Polyhedron, v. 100, p. 10-16. 0277-5387 http://hdl.handle.net/11449/171978 10.1016/j.poly.2015.07.009 2-s2.0-84938576973 2-s2.0-84938576973.pdf 7927677053650819 0000-0002-0057-7964
url	http://dx.doi.org/10.1016/j.poly.2015.07.009 http://hdl.handle.net/11449/171978
identifier_str_mv	Polyhedron, v. 100, p. 10-16. 0277-5387 10.1016/j.poly.2015.07.009 2-s2.0-84938576973 2-s2.0-84938576973.pdf 7927677053650819 0000-0002-0057-7964
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Polyhedron 0,472
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	10-16 application/pdf
dc.source.none.fl_str_mv	Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP
instname_str	Universidade Estadual Paulista (UNESP)
instacron_str	UNESP
institution	UNESP
reponame_str	Repositório Institucional da UNESP
collection	Repositório Institucional da UNESP
repository.name.fl_str_mv	Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity

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