Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10661-017-6062-8 http://hdl.handle.net/11449/169869 |
Resumo: | Several mutagenic agents may be present in substances released in the environment, which may cause serious environmental impacts. Among these substances, there is a special concern regarding the widespread use of silver nanoparticles (AgNP) in several products due to their widely known bactericidal properties, including in the medical field and the food industry (e.g., active packaging). The assessment of the effects of AgNP released in the environment, having different concentrations, sizes, and being associated or not to other types of materials, including polymers, is therefore essential. In this research, the objective was to evaluate the genotoxic and cytotoxic effects of AgNP (size range between 2 and 8 nm) on root meristematic cells of Allium cepa (A. cepa). Tests were carried out in the presence of colloidal solution of AgNP and AgNP mixed with carboxymethylcellulose (CMC), using distinct concentrations of AgNP. As a result, when compared to control samples, AgNP induced a mitotic index decrease and an increase of chromosomal aberration number for two studied concentrations. When AgNP was in the presence of CMC, no cytotoxic potential was verified, but only the genotoxic potential for AgNP dispersion having concentration of 12.4 ppm. |
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Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepaAllium cepaCarboxymethylcelluloseChromosomal aberrationMitotic testSilver nanoparticlesSeveral mutagenic agents may be present in substances released in the environment, which may cause serious environmental impacts. Among these substances, there is a special concern regarding the widespread use of silver nanoparticles (AgNP) in several products due to their widely known bactericidal properties, including in the medical field and the food industry (e.g., active packaging). The assessment of the effects of AgNP released in the environment, having different concentrations, sizes, and being associated or not to other types of materials, including polymers, is therefore essential. In this research, the objective was to evaluate the genotoxic and cytotoxic effects of AgNP (size range between 2 and 8 nm) on root meristematic cells of Allium cepa (A. cepa). Tests were carried out in the presence of colloidal solution of AgNP and AgNP mixed with carboxymethylcellulose (CMC), using distinct concentrations of AgNP. As a result, when compared to control samples, AgNP induced a mitotic index decrease and an increase of chromosomal aberration number for two studied concentrations. When AgNP was in the presence of CMC, no cytotoxic potential was verified, but only the genotoxic potential for AgNP dispersion having concentration of 12.4 ppm.Programa de Pós-Graduação em Biotecnologia (PPGBiotec) Centro de Ciências Exatas e Tecnologia Universidade Federal de São Carlos (UFSCar)Laboratório Nacional de Nanotecnologia para o Agronegócio (LNNA) EMBRAPA InstrumentaçãoPrograma de Pós-Graduação em Química (PPGQ) Centro de Ciências Exatas e Tecnologia Universidade Federal de São Carlos (UFSCar)Departamento de Física e Química UNESPDepartamento de Física e Química UNESPUniversidade Federal de São Carlos (UFSCar)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Universidade Estadual Paulista (Unesp)Becaro, Aline A.Siqueira, Maria CéliaPuti, Fernanda C.de Moura, Marcia Regina [UNESP]Correa, Daniel S.Marconcini, José ManoelMattoso, Luiz H. C.Ferreira, Marcos David2018-12-11T16:47:57Z2018-12-11T16:47:57Z2017-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1007/s10661-017-6062-8Environmental Monitoring and Assessment, v. 189, n. 7, 2017.1573-29590167-6369http://hdl.handle.net/11449/16986910.1007/s10661-017-6062-82-s2.0-850213531552-s2.0-85021353155.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Monitoring and Assessment0,5890,589info:eu-repo/semantics/openAccess2024-01-29T06:31:38Zoai:repositorio.unesp.br:11449/169869Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:14:31.404076Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa |
title |
Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa |
spellingShingle |
Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa Becaro, Aline A. Allium cepa Carboxymethylcellulose Chromosomal aberration Mitotic test Silver nanoparticles |
title_short |
Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa |
title_full |
Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa |
title_fullStr |
Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa |
title_full_unstemmed |
Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa |
title_sort |
Cytotoxic and genotoxic effects of silver nanoparticle/carboxymethyl cellulose on Allium cepa |
author |
Becaro, Aline A. |
author_facet |
Becaro, Aline A. Siqueira, Maria Célia Puti, Fernanda C. de Moura, Marcia Regina [UNESP] Correa, Daniel S. Marconcini, José Manoel Mattoso, Luiz H. C. Ferreira, Marcos David |
author_role |
author |
author2 |
Siqueira, Maria Célia Puti, Fernanda C. de Moura, Marcia Regina [UNESP] Correa, Daniel S. Marconcini, José Manoel Mattoso, Luiz H. C. Ferreira, Marcos David |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Becaro, Aline A. Siqueira, Maria Célia Puti, Fernanda C. de Moura, Marcia Regina [UNESP] Correa, Daniel S. Marconcini, José Manoel Mattoso, Luiz H. C. Ferreira, Marcos David |
dc.subject.por.fl_str_mv |
Allium cepa Carboxymethylcellulose Chromosomal aberration Mitotic test Silver nanoparticles |
topic |
Allium cepa Carboxymethylcellulose Chromosomal aberration Mitotic test Silver nanoparticles |
description |
Several mutagenic agents may be present in substances released in the environment, which may cause serious environmental impacts. Among these substances, there is a special concern regarding the widespread use of silver nanoparticles (AgNP) in several products due to their widely known bactericidal properties, including in the medical field and the food industry (e.g., active packaging). The assessment of the effects of AgNP released in the environment, having different concentrations, sizes, and being associated or not to other types of materials, including polymers, is therefore essential. In this research, the objective was to evaluate the genotoxic and cytotoxic effects of AgNP (size range between 2 and 8 nm) on root meristematic cells of Allium cepa (A. cepa). Tests were carried out in the presence of colloidal solution of AgNP and AgNP mixed with carboxymethylcellulose (CMC), using distinct concentrations of AgNP. As a result, when compared to control samples, AgNP induced a mitotic index decrease and an increase of chromosomal aberration number for two studied concentrations. When AgNP was in the presence of CMC, no cytotoxic potential was verified, but only the genotoxic potential for AgNP dispersion having concentration of 12.4 ppm. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07-01 2018-12-11T16:47:57Z 2018-12-11T16:47:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10661-017-6062-8 Environmental Monitoring and Assessment, v. 189, n. 7, 2017. 1573-2959 0167-6369 http://hdl.handle.net/11449/169869 10.1007/s10661-017-6062-8 2-s2.0-85021353155 2-s2.0-85021353155.pdf |
url |
http://dx.doi.org/10.1007/s10661-017-6062-8 http://hdl.handle.net/11449/169869 |
identifier_str_mv |
Environmental Monitoring and Assessment, v. 189, n. 7, 2017. 1573-2959 0167-6369 10.1007/s10661-017-6062-8 2-s2.0-85021353155 2-s2.0-85021353155.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Environmental Monitoring and Assessment 0,589 0,589 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129599564939264 |