Comparação in vivo da biocompatilidade de amostras com superfície porosa confeccionadas com diferentes ligas de titânio

• Autor(a) principal: Santos, Evelyn Luzia de Souza [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/108846
• topic: Osseointegração; Ligas de titanio; Porosidade

Today, the implantology concentrates in studies that direct and enable a faster osseointegration of surgical implants. The purpose of this study was to compare the bone neoformations with porous surface samples, made of different titanium alloys with low elastic modulus. By means of powder metallurgy, 75 samples were made and split into five groups: a) Group 1: control - commercially pure titanium (cpTi); b) Group 2: titanium-6aluminium-4vanadium (Ti-6Al-4V) alloy; c) Group 3: Ti-13Nb-13Zr (titanium-niobium-zirconium) alloy; d) Group 4: titanium-35niobium (Ti-35Nb) alloy; e) Group 5: titanium-35niobium-7zirconium-5tantalum (Ti-35Nb-7Zr-5Ta). Five samples of each group were submitted to chemical and morphological characterization. In this study fifteen rabbits were used to evaluate and to compare the bone neoformation obtained from the porous surface samples, by means of histological and histomorphometric analysis. Each rabbit received one sample from each group; the G1, G2, G3 samples were inserted into the right tibiae and the G4, G5 samples in the left tibiae. Five rabbits, randomly selected, were euthanized 2, 4 and 8 weeks after the surgery. The results of the morphological characterization of the samples confirmed 40% porosity, and through the scanning electron microscope (SEM) the samples showed the surface pores open and integrated with the dense core structure. The analysis by energy-dispersive X-ray spectroscopy (EDS) showed the presence and the peak of each specific chemical element of the used alloys. The histological and histomorphometric analysis showed a greater bone neoformation in the titanium alloys during the initial period, when compared with cpTi and Ti-6Al-4V. It was concluded that the samples made of titanium alloys with low elastic modulus have better influence on the osteoblasts, in the initial period, favoring an early osseointegration