p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/225387 |
Resumo: | Background: Models have suggested esophageal carcinogenesis can result from the alteration of sequences, leading to esophagitis, atrophy, dysplasia, carcinoma in situ and invasive carcinoma. While numerous genetic alterations have been reported in esophageal carcinogenesis, studies of benign lesions with precancerous potential are scarce. Materials and Methods: Immunohistochemistry was performed for p53, p16 and Fhit proteins in the esophageal mucosa from patients with Chagas disease (CD), chagasic megaesophagus (CM), chronic esophagitis (CE), esophageal squamous cell carcinoma (ESCC) and in normal mucosa (NM). Results: The proportion of p53-positive cases increased progressively according to the severity of the pathology CD (7.7%), CM (26.1%), CE (52.2%) and ESCC (100%). However, p16 and Fhit did not show any statistically significant differences among the groups. Conclusion: p53 overexpression is involved in the initial steps of esophageal carcinogenesis, supporting further evaluation of its utility as a marker in precursor lesions, conversely, losses of Fhit and p16 expression may not be significant. |
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p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas diseaseEsophageal carcinomaEsophagitisFhit proteinMegaesophagusp16p53Background: Models have suggested esophageal carcinogenesis can result from the alteration of sequences, leading to esophagitis, atrophy, dysplasia, carcinoma in situ and invasive carcinoma. While numerous genetic alterations have been reported in esophageal carcinogenesis, studies of benign lesions with precancerous potential are scarce. Materials and Methods: Immunohistochemistry was performed for p53, p16 and Fhit proteins in the esophageal mucosa from patients with Chagas disease (CD), chagasic megaesophagus (CM), chronic esophagitis (CE), esophageal squamous cell carcinoma (ESCC) and in normal mucosa (NM). Results: The proportion of p53-positive cases increased progressively according to the severity of the pathology CD (7.7%), CM (26.1%), CE (52.2%) and ESCC (100%). However, p16 and Fhit did not show any statistically significant differences among the groups. Conclusion: p53 overexpression is involved in the initial steps of esophageal carcinogenesis, supporting further evaluation of its utility as a marker in precursor lesions, conversely, losses of Fhit and p16 expression may not be significant.Department of Biology UNESP Säo Paulo State University, SPLaboratory of Surgery and Molecular Pathology Hospital Sírio Libanês, São Paulo, SPDepartment of Pathology FAMERP - Medical School, São José do Rio Preto, SPIBILCE UNESP Departamento de Biologia, Rua Cristóvão Colombo, 2265, São José do Rio Preto, SP - CEP. 15054-000Department of Biology UNESP Säo Paulo State University, SPIBILCE UNESP Departamento de Biologia, Rua Cristóvão Colombo, 2265, São José do Rio Preto, SP - CEP. 15054-000Universidade Estadual Paulista (UNESP)Hospital Sírio LibanêsFAMERP - Medical SchoolBellini, Marilanda Ferreira [UNESP]Leite, Kátia Ramos MoreiraCury, Patrícia MalufSilva, Ana Elizabete [UNESP]2022-04-28T20:48:14Z2022-04-28T20:48:14Z2008-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article3793-3799Anticancer Research, v. 28, n. 6 A, p. 3793-3799, 2008.0250-7005http://hdl.handle.net/11449/2253872-s2.0-58149174373Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnticancer Researchinfo:eu-repo/semantics/openAccess2022-04-28T20:48:14Zoai:repositorio.unesp.br:11449/225387Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:56:44.474359Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease |
title |
p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease |
spellingShingle |
p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease Bellini, Marilanda Ferreira [UNESP] Esophageal carcinoma Esophagitis Fhit protein Megaesophagus p16 p53 |
title_short |
p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease |
title_full |
p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease |
title_fullStr |
p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease |
title_full_unstemmed |
p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease |
title_sort |
p53, p16 and Fhit proteins expressions in chronic esophagitis and Chagas disease |
author |
Bellini, Marilanda Ferreira [UNESP] |
author_facet |
Bellini, Marilanda Ferreira [UNESP] Leite, Kátia Ramos Moreira Cury, Patrícia Maluf Silva, Ana Elizabete [UNESP] |
author_role |
author |
author2 |
Leite, Kátia Ramos Moreira Cury, Patrícia Maluf Silva, Ana Elizabete [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Hospital Sírio Libanês FAMERP - Medical School |
dc.contributor.author.fl_str_mv |
Bellini, Marilanda Ferreira [UNESP] Leite, Kátia Ramos Moreira Cury, Patrícia Maluf Silva, Ana Elizabete [UNESP] |
dc.subject.por.fl_str_mv |
Esophageal carcinoma Esophagitis Fhit protein Megaesophagus p16 p53 |
topic |
Esophageal carcinoma Esophagitis Fhit protein Megaesophagus p16 p53 |
description |
Background: Models have suggested esophageal carcinogenesis can result from the alteration of sequences, leading to esophagitis, atrophy, dysplasia, carcinoma in situ and invasive carcinoma. While numerous genetic alterations have been reported in esophageal carcinogenesis, studies of benign lesions with precancerous potential are scarce. Materials and Methods: Immunohistochemistry was performed for p53, p16 and Fhit proteins in the esophageal mucosa from patients with Chagas disease (CD), chagasic megaesophagus (CM), chronic esophagitis (CE), esophageal squamous cell carcinoma (ESCC) and in normal mucosa (NM). Results: The proportion of p53-positive cases increased progressively according to the severity of the pathology CD (7.7%), CM (26.1%), CE (52.2%) and ESCC (100%). However, p16 and Fhit did not show any statistically significant differences among the groups. Conclusion: p53 overexpression is involved in the initial steps of esophageal carcinogenesis, supporting further evaluation of its utility as a marker in precursor lesions, conversely, losses of Fhit and p16 expression may not be significant. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-11-01 2022-04-28T20:48:14Z 2022-04-28T20:48:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Anticancer Research, v. 28, n. 6 A, p. 3793-3799, 2008. 0250-7005 http://hdl.handle.net/11449/225387 2-s2.0-58149174373 |
identifier_str_mv |
Anticancer Research, v. 28, n. 6 A, p. 3793-3799, 2008. 0250-7005 2-s2.0-58149174373 |
url |
http://hdl.handle.net/11449/225387 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anticancer Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
3793-3799 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128725772926976 |